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Which ventilator mode lets children breathe easiest?

NCT ID NCT07796321

Knowledge-focused Sponsor: The Hospital for Sick Children Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 02, 2026 · Updated 1 time

Summary

This trial tests two ventilator modes in children who need a machine to breathe. The goal is to see which mode reduces the effort of breathing and improves comfort. Researchers will measure how hard children work to breathe and how often breathing is out of sync with the ventilator. The study includes children from birth to 18 years old who are in the weaning phase of ventilation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Two ventilator modes: pressure control mode and pressure support mode
What this could lead to
If one mode proves better, it could guide how doctors set ventilators for children, making breathing less tiring and more comfortable.
What could go wrong
This is a small, early study with only 25 children, so results may not apply to all patients. Measuring breathing effort is complex and may not capture all differences.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Up to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Consent provided 2. Aged: birth to 18 years of age 3. Invasively mechanically ventilated and expected to remain intubated for ≥ 6 hours, in the ventilator weaning phase. Exclusion Criteria: 1. Contraindication for esophageal catheter placement such as esophageal repair (e.g. esophageal surgery or esophageal varices) 2. On Extracorporeal Membrane Oxygenation (ECMO) 3. Undergoing assessment for brain death or brain death confirmed 4. Patients with a severe systemic disease that poses a constant threat to their life: * \<24 hrs post cardiac arrest * 2 or more inotropes increasing by \>20% within the last 24 hrs * increase in ventilation support or an FiO2 change ≥30% within the last 24 hrs * most responsible physician (MRP) determine patient is not eligible for the study intervention

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilation Paediatric dysfunctional breathing Paediatric intensive care

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Hospital for Sick Children (SickKids)

    Toronto, Ontario, M5G 1E8, Canada

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