Burn

This study tests a technique called acute normovolemic hemodilution (ANH) in 2000 high-risk heart surgery patients. Before the heart-lung machine is used, doctors remove some blood and replace it with fluids. The goal is to see if this reduces the number of patients who need a bl…

This study tests if a gentle, non-invasive stimulation on the ear can help adults with moderate to severe burns recover faster. Researchers will measure inflammation and physical function in 50 participants who receive either standard physiotherapy or physiotherapy plus the ear s…

This study tested whether giving high doses of vitamin C through an IV to severely burned patients could prevent organ failure and death. About 666 adults with deep burns covering at least 20% of their body were to receive either vitamin C or a placebo, alongside standard care. T…

This study was designed to see if giving calcium right away to trauma patients who need large blood transfusions could help their blood clot better, reduce the need for more transfusions, and improve survival. The trial was withdrawn before enrolling any participants, so no resul…

This study is testing a product called Cohealyx, a collagen matrix placed on deep wounds after surgery to help them heal enough for a skin graft. The trial involves 41 people with full-thickness wounds from burns or trauma. Researchers want to see how long it takes for Cohealyx t…

This study tests a new synthetic skin substitute called NovoSorb BTM for treating severe burns. About 150 adults with deep burns covering 3% to 60% of their body will receive either the new matrix or standard care. The goal is to see if the new material helps burns close complete…

This study tests a new heating device called Therm'Up to manage hypothermia in trauma patients. Hypothermia, when body temperature drops below 35°C, can worsen injuries and increase death risk. The trial will enroll 100 adults at risk of hypothermia due to trauma, cold exposure, …

This study tests whether a special fish skin graft can help deep burn wounds heal without needing as much skin taken from the patient's own body. About 65 adults with deep partial-thickness burns will receive both the fish skin graft and a standard skin graft on different burn ar…

This study tests a new lab-grown skin substitute (EHSG-KF) for treating deep burns in adults and teens. It compares the substitute to standard skin grafts to see if it covers wounds better and is safer. The goal is to improve healing and reduce the need for large skin donations f…

This study looks at whether a strong antibiotic called meropenem (a carbapenem) works better than another antibiotic called piperacillin/tazobactam for treating sepsis in burn patients. Sepsis is a life-threatening infection that can happen after severe burns. The study will trac…

This study tests whether a special lipid cream (EpiCeram) can prevent healed chronic wounds—like diabetic foot ulcers or pressure sores—from reopening. About 100 adults with recently healed wounds will apply either the cream or Vaseline for 3 months. Researchers will measure skin…

This study tests whether a fluorescent dye called indocyanine green (ICG) can help surgeons see exactly which parts of a burn wound are dead or inflamed. Up to 100 burn patients will receive the dye and have their wounds imaged with a special camera before and during surgery. The…

This study tests a program designed to prevent opioid misuse in people hospitalized for a traumatic injury. Participants complete brief questionnaires about pain and opioid use risk, and receive enhanced care coordination based on their responses. The goal is to see if this adapt…

This study looks at whether a fall prevention discharge class can reduce repeat fall-related ER visits in adults aged 60 and older. Researchers will compare those who attended the class to those who did not. The goal is to see if this simple education step can help prevent future…

This study tests whether a structured physical therapy program (STAT) helps people with severe burns recover better than standard therapy. About 166 adults aged 18-65 with burns covering at least 15% of their body will take part at seven burn centers. The main goal is to see if t…

This study tests a communication tool called Best Case/Worst Case-ICU for older adults (50+) with serious injuries in the ICU. The tool helps doctors, patients, and families discuss possible outcomes and treatment options using simple graphics. Researchers will measure if it impr…

This study tests whether a 6-week pulmonary rehabilitation program—combining breathing exercises and arm workouts—can improve lung function and physical ability in adults who had burns on their arms. Sixty-four participants will be randomly assigned to either the rehab program or…

This pilot study tests whether robot-assisted gait training can improve walking in people with lower limb burns and fractures. Five participants will receive 30 minutes of robot training plus 30 minutes of conventional therapy daily for 8 weeks. The goal is to see if this combina…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce anxiety, improve sleep, and lessen pain and itching in adults recovering from burn injuries. About 60 participants will either get standard physical therapy plus this nerve st…

This trial tests whether a Pain and Coordination Plan (PAC-plan) can reduce opioid use and improve quality of life in adults who have had surgery after an accidental injury. Participants receive the plan at hospital discharge, which includes an opioid management plan, a follow-up…

This study looks at whether a non-invasive device that stimulates the vagus nerve can improve anxiety, sleep, pain, and itching in teenagers aged 12-18 who have had burn injuries. About 60 participants will either get this stimulation plus standard physical therapy, or just stand…

This study tests whether a non-invasive device that stimulates the vagus nerve can reduce pain and anxiety and improve quality of life for burn patients during dressing changes. About 96 adults with second-degree burns will be randomly assigned to receive the stimulation before o…

This study tests a brief stepped care program for adults hospitalized after a traumatic injury who show signs of PTSD. The program starts in the hospital and aims to reduce PTSD symptoms and the number of emergency room visits over time. About 424 participants are involved, and t…

This study looks at whether progressive muscle relaxation exercises can improve sleep, reduce anxiety, and help body image in people with burn injuries. About 100 adults with second-degree burns will either do these exercises twice daily for a week or receive standard care. The g…

This study tests if microneedling, a technique that creates tiny skin channels, followed by cortisone cream can improve burn scars. It aims to make scars softer, thinner, and less red. The trial includes 36 adults with at least two burn scars.

This study tests whether watching a custom 360-degree virtual reality video during dressing changes can lower pain, anxiety, and the need for opioid painkillers in adults recovering from burn surgery. Eighty participants will wear VR headsets while their bandages are changed and …

This study tests a program called BreeZe that helps burn survivors take charge of their recovery. The goal is to improve quality of life by teaching skills like goal-setting and problem-solving. About 146 adults from three burn centers in the Netherlands will take part. Researche…

This pilot study tests a custom-made mouthpiece created with 3D scanning and printing for people whose mouths became tight after burn scars. Ten participants will wear the mouthpiece all day except during meals for two months. Researchers will measure if it improves mouth opening…

This study tests a method called conditioning open-label placebo (COLP) to help patients with spinal cord injury, multiple injuries, or burns use fewer opioids while still getting the same pain relief. About 66 adults in intensive rehab will receive a placebo alongside their regu…

This study tests whether taking a person's own fat and injecting it into burn scars on the arms can improve scar appearance and movement better than standard treatments like steroid shots or surgery. Forty adults with burn scars will be randomly assigned to fat grafting or usual …

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study aimed to compare three medicines (propofol, etomidate, and ketamine) given to adult trauma patients to help them breathe with a breathing tube. The goal was to see which drug leads to the best outcomes, like survival and fewer side effects. However, the study was withd…

This study looks at how the body's natural response to severe injury or major surgery can sometimes go wrong, leading to complications. Researchers will collect blood samples from 320 trauma patients and elective surgery patients to measure markers of inflammation and blood clott…

This observational registry will follow 5,000 adults with various wounds—like diabetic foot ulcers, burns, or surgical wounds—to see how different treatments (e.g., hydrocolloid, foam, silver dressings) perform in everyday medical settings. Researchers will measure wound healing,…

This study is tracking over 600 people who received the GORE VIABAHN stent-graft as part of their normal medical care for conditions like peripheral artery disease or aneurysms. Researchers are monitoring how often serious device-related problems occur. The goal is to see how saf…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study was designed to observe and compare the quality of burn scars in people treated with two different skin substitutes—Integra and NovoSorb BTM—12 to 36 months after their final skin graft. Researchers planned to review medical records, use non-invasive scar measurements,…

This study will track 100 people with traumatic hand and wrist injuries at Sohag University Hospital in Egypt from October 2025 to April 2026. Researchers want to learn how these injuries happen and what the outcomes are. It is an observational study, meaning no new treatment is …

This study looks at how low-level laser therapy (red light at 660 nm) affects the stiffness of chronic and burn wounds. Researchers will measure stiffness before and after a 3-minute laser treatment using two devices: OCT and MyotonPRO. The goal is to see if laser therapy changes…

This study planned to see if a cheap thermal camera that attaches to a smartphone could help doctors figure out how deep a child's second-degree burn is. Deep burns often need skin grafts, but it can take over a week to tell. The idea was that deeper, cooler areas would show up o…