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Trauma ICU survivors: new study tracks hidden brain decline

NCT ID NCT03098459

Ongoing Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover links between trauma and conditions like dementia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this study could reveal why some trauma patients develop long-term cognitive issues, pointing toward ways to prevent or treat them.

What could go wrong

This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may take years to translate into real-world help.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease brain disorder Brain Injuries, Traumatic burn Cognitive Dysfunction Craniocerebral Trauma Critical Illness delirium dementia early-onset autosomal dominant Alzheimer disease Hematoma, Subdural Inflammation injury intracerebral hemorrhage Multiple Trauma Neuroinflammatory Diseases subarachnoid hemorrhage traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER; EARLY ONSET COGNITIVE IMPAIRMENT CRITICAL ILLNESS DELIRIUM ICU POLYTRAUMA TRAUMA TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37212, United States