DELIRIUM

This study aims to find out which of two common sedative drugs is better for protecting brain function in infants and children who need a breathing machine in the intensive care unit. It will compare dexmedetomidine and midazolam in 372 young patients to see which one reduces del…

This study is testing whether having nurses perform a daily, brief confusion check (called the UB-CAM) on older hospital patients can help catch delirium early. The goal is to see if this routine screening leads to fewer falls, less use of sedating medications or restraints, and …

This study is testing whether a medication called dexmedetomidine, given at night to help patients sleep, can prevent delirium (sudden, severe confusion) in older adults after heart surgery. It will involve 1,800 patients aged 60+ who are having heart surgery and will stay in the…

This small study is testing whether melatonin, a natural sleep hormone, can help reduce the duration of delirium in critically ill patients in intensive care. Researchers want to see if it's practical to run a larger future trial by measuring how many patients they can enroll and…

This study is testing if fluvoxamine, an existing medication, can prevent delirium (sudden, severe confusion) in older adults after non-heart, non-brain surgery. Researchers believe inflammation after surgery may cause delirium and that fluvoxamine might reduce this inflammation.…

This study tests if involving family members in a proven hospital care program is better at preventing delirium (sudden, severe confusion) in older patients. It will compare the standard Hospital Elder Life Program (HELP) with a new version that trains and includes family caregiv…

This study is testing whether using a lighter level of general anesthesia during major surgery can help protect older adults' brains. It compares 'light' anesthesia to the usual 'deep' anesthesia to see if the lighter approach reduces post-surgery confusion (delirium) and long-te…

This study is testing a program designed to prevent delirium, a common and serious state of confusion after surgery in older adults. Researchers will first test patients' memory before surgery to identify those at highest risk. Those patients and their care teams will then receiv…

This study is testing whether a sedative drug called dexmedetomidine can prevent long-term memory and thinking problems that sometimes occur after heart surgery. It will involve 2,400 patients aged 60 and older who are having planned heart surgery. Researchers will compare the dr…

This study is testing whether listening to music can prevent delirium, a serious state of confusion, in older adults who are critically ill in the Intensive Care Unit (ICU). Researchers will compare two types of music—personalized playlists and generic relaxing music—against stan…

This large study is testing whether carefully managing a patient's body temperature during major cancer surgery can prevent post-operative delirium (a serious state of confusion) and improve long-term survival. It will involve nearly 4,000 older patients (65+) undergoing lengthy …

This study is testing if combining two sedative drugs, dexmedetomidine and esketamine, can reduce the risk of delirium in older patients recovering from surgery in the intensive care unit (ICU). Delirium is a serious confusion that can lead to longer hospital stays and long-term …

This study is testing whether a virtual reality system that lets family members visit can help reduce delirium in ICU patients who are on breathing machines. Researchers will give 102 patients VR headsets to block out the stressful ICU environment and connect them with family for…

This study is testing whether using immersive virtual reality (VR) can help reduce discomfort for patients recovering from major surgery in a surgical intensive care unit (ICU). Researchers will enroll 194 adults who have had major heart, chest, or abdominal surgery and are expec…

This study is testing whether a simple, non-invasive ear clip can safely help patients in the ICU who develop sudden, severe confusion known as delirium. The clip sends gentle electrical pulses to a nerve in the ear, which researchers hope might improve brain function. The main g…

This project aims to improve patient comfort before surgery by reducing unnecessarily long fasting times. It will test a new rule allowing patients to drink clear liquids until they are called to the operating room, instead of fasting for many hours. The study will see if this sh…

This study is testing if giving a small dose of a sedative called midazolam during the start of anesthesia helps prevent confusion and anxiety in older adults after surgery. Researchers will compare the drug to a placebo in over 600 patients aged 65-85. The main goal is to see if…

This small pilot study is testing whether playing voice recordings from loved ones can help manage delirium (sudden, severe confusion) in intensive care unit (ICU) patients. Fifteen surgical ICU patients at risk for delirium will listen to 20-25 minute recordings twice daily for …

This small pilot study is creating and testing a new type of music therapy to help prevent delirium—a state of sudden confusion—in hospitalized patients with Alzheimer's, Parkinson's, or similar brain diseases. Up to 30 participants will receive up to five personalized music sess…

This study aims to find the best medication to calm severe agitation and restlessness (called agitated delirium) in hospitalized cancer patients. Researchers are comparing three different calming drugs against a placebo (a treatment with no active drug), along with standard comfo…

This study aims to find the best way to help intensive care unit (ICU) teams consistently use a proven set of care practices known as the ABCDEF bundle. Researchers will test two different support strategies for hospital staff across 12 ICUs, involving about 8,100 critically ill …

This study aims to understand why some older adults become confused (delirious) after major surgery. Researchers will measure brain activity, take images, and test blood and spinal fluid from about 468 patients before and after their operations. The goal is to find biological sig…

This study is testing whether a new wearable device and computer software can safely and effectively monitor brain blood flow in people at home. It will involve 140 people, including healthy older adults and those who have had a stroke, dementia, depression, or delirium. The main…

This study aims to understand the recovery challenges patients face after experiencing delirium in the Intensive Care Unit (ICU). Researchers will follow 189 patients as they move from the ICU to a regular hospital ward, tracking their physical abilities, thinking skills, and men…