DELIRIUM

This phase 2 trial is testing whether a dissolvable film containing dexmedetomidine (BXCL501) can safely and effectively reduce agitation in adult ICU patients who have delirium. The study will compare four different starting doses of the drug against a placebo to find the best b…

This study tests whether guided meditation delivered through a tablet or virtual reality headset can reduce the risk of delirium in hospitalized adults. Delirium is a sudden state of confusion that can occur during a hospital stay, especially in the ICU. The trial will measure ch…

This study looks at how well two drugs, haloperidol and lorazepam, can control severe agitation and confusion (delirium) in people with advanced cancer who are in palliative care. About 110 patients will be enrolled to compare different drug approaches. The goal is to improve com…

This pilot study tests whether a daily 15-minute massage plus guided relaxation with music can prevent delirium in critically ill patients. About 120 adults in the ICU will be randomly assigned to receive the relaxation intervention or standard care for up to five days. The main …

This study aimed to see if trazodone works better than quetiapine or a placebo for treating confusion (delirium) in adult surgical ICU patients. It planned to measure how long delirium lasts, sleep quality, and side effects. However, the study was withdrawn before enrolling any p…

This study tests a mobile app called iPREPARED that helps patients and their caregivers prepare for a hospital stay. The app provides videos and tips to prevent or reduce delirium, a sudden confused state common in older adults. Researchers want to see if the app is easy to use a…

This study tests whether giving haloperidol alone or with chlorpromazine can safely calm severe agitation and confusion (delirium) in 70 advanced cancer patients in a palliative care unit. The main goal is to see if the drugs improve sedation scores within 24 hours. It is a phase…

This study explores whether wearable accelerometers and cameras can automatically detect delirium in intensive care unit patients by tracking changes in movement and facial expressions. Delirium, a sudden state of confusion, often goes undetected despite being common in hospitali…

This study explores whether artificial intelligence and video monitoring can recognize pain and delirium in intensive care unit (ICU) patients who cannot communicate verbally. Researchers will use cameras, accelerometers, and other sensors to capture facial expressions and body m…

This study looks at whether pausing sedation each day in mechanically ventilated ICU patients can reduce the amount of blood pressure medication they need. Researchers will compare medication doses before and during these daily awakening trials. The goal is to see if this simple …

This study looks at whether a special recovery program can help older adults (65+) who experienced confusion (delirium) after emergency surgery. Participants will have virtual visits with a care coordinator and complete physical, cognitive, and psychological assessments over 18 m…

This study investigates cognitive problems in intensive care patients with acute respiratory distress syndrome (ARDS) who develop delirium (sudden confusion). Researchers use a non-invasive EEG cap and auditory tests to measure brain activity at the bedside. The goal is to identi…

This study was designed to test whether scheduled video calls with a nurse could help family members who make medical decisions for hospitalized older adults with Alzheimer's or similar cognitive issues. The goal was to improve communication and reduce anxiety and depression. How…

This study looks at whether stopping overnight neurological checks in stroke patients can help prevent delirium, a common and serious complication. Researchers will compare patients who continue standard overnight checks with those who have them stopped, measuring rates of deliri…

This study aimed to see how common delirium is in children in the pediatric intensive care unit (PICU) by using a French version of a screening tool called the Cornell Assessment of Pediatric Delirium (CAPD). The plan was to check each child twice a day during their stay. However…

This study follows 826 ICU survivors to understand why some develop long-term thinking and memory problems. Researchers will look at factors like delirium and sedative use during the ICU stay. The goal is to find modifiable risks that could lead to better prevention and recovery …

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study follows over 1,000 children aged 0-21 who are getting stem cell transplants. Researchers will check for delirium twice a day during their hospital stay. The goal is to learn how often delirium happens, what raises the risk, and how it affects recovery. This information…

This study looks at 600 adults who take blood thinners and have a mild head injury but a normal first brain scan. Researchers want to know how often a delayed brain bleed happens within 24 hours and up to 4 weeks after the injury. They also track risks like blood clots or confusi…

This study planned to test a noninvasive device that stimulates the vagus nerve through the skin to see if it could help people recover consciousness more quickly after anesthesia. The researchers wanted to enroll adults undergoing lumbar spine surgery and measure how fast they w…

This study follows 505 adults aged 50 and older who are having hip or knee replacement surgery. Researchers use a simple online card-game test to measure changes in memory, attention, and thinking before and up to 4.5 months after surgery. The goal is to find out how many people …