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Waking ICU patients daily may lower blood pressure drug needs

NCT ID NCT03182335

Knowledge-focused Sponsor: University of Chicago Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study looks at whether pausing sedation each day in mechanically ventilated ICU patients can reduce the amount of blood pressure medication they need. Researchers will compare medication doses before and during these daily awakening trials. The goal is to see if this simple practice can help manage blood pressure more effectively and possibly lower the risk of delirium.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sedation awakening trial (SAT)
What this could lead to
If successful, this could help ICU doctors better manage sedation and blood pressure medications, potentially reducing delirium and improving patient outcomes.
What could go wrong
This is an observational study, not a treatment trial. Results may not change practice and could vary widely among patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 800 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2014

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

adult patients admitted to the intensive care unit

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * requiring Mechanical ventilation through an endotracheal tube with infusion of sedative or analgesic agent for comfort * requiring vasoactive drug via central venous catheter for the treatment of shock Exclusion Criteria: * patients receiving Dexmedetomidine as sedative

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Conditions

The condition(s) this trial relates to.

Critical Illness delirium hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Delirium Low blood pressure

Contacts and locations

Locations

  • The University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.