Can melatonin help ICU patients snap out of delirium?

NCT ID NCT05713877

Recruiting now Symptom relief Sponsor: Ciusss de L'Est de l'Île de Montréal Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether melatonin, a natural sleep hormone, can help treat delirium in intensive care unit (ICU) patients. Delirium is a state of confusion and disorientation common in critically ill people. The trial will give 30 patients either melatonin or a placebo every evening for up to 14 days. The main goal is to see if a larger study is possible, and to check if melatonin shortens the time patients remain delirious.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Melatonin
What this could lead to: If it works, this could point toward a simple, safe treatment to reduce delirium duration in critically ill patients.
What could go wrong: This is a very small feasibility trial with only 30 participants, so results may not be conclusive. Delirium has many causes, and melatonin may not work for everyone.

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Conditions

The condition(s) this trial relates to.

Critical Illness delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DELIRIUM

Contacts and locations

Locations

Hopital Maisonneuve-Rosemont
RECRUITING

Montreal, Quebec, H1T 2M4, Canada

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