Lighter anesthesia may shield seniors from Post-Surgery confusion

NCT ID NCT06268080

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium—sudden confusion—and long-term memory problems. About 2,766 participants will be randomly assigned to one of two anesthesia levels, guided by a brain monitor. If effective, this simple change could help millions of seniors stay mentally sharp after surgery.

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Conditions

The condition(s) this trial relates to.

Cognition Disorders cognitive disorder Cognitive Dysfunction delirium Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Auckland City Hospital, Health New Zealand

    RECRUITING

    Grafton, Auckland, 1024, New Zealand

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Email: •••••@•••••

  • Christchurch Hospital

    RECRUITING

    Christchurch, South Island, 4710, New Zealand

  • North Shore Hospital

    NOT_YET_RECRUITING

    Auckland, North Island, 0622, New Zealand