COGNITIVE DECLINE

This pilot study is testing a 3-month personalized program to see if it can improve physical, mental, and immune health in older adults. The program combines lifestyle changes like exercise and diet with specific medications and supplements. Researchers will enroll about 20 seden…

This study has two main goals. First, it aims to find out how common memory and thinking problems are in older adults with type 2 diabetes. Second, it will test a 2-year personalized health program designed to slow down cognitive decline. The program combines medication managemen…

This study is comparing two different forms of a brain nutrient called DHA to see which one is better at getting into the brain and spinal fluid of older adults who are noticing early signs of memory decline. Researchers will give 153 participants either one of the DHA supplement…

This study is testing whether a daily broccoli sprout extract can help improve memory, attention, and thinking skills in older adults with mild cognitive impairment. For 12 weeks, 100 participants will take either the extract or a placebo pill. Researchers will measure changes in…

This 8-week study is testing whether a dietary supplement called Sabroxy® can help improve both blood sugar control and memory in adults. Researchers will enroll 120 adults aged 40-80 who have mild memory concerns and insulin resistance. Participants will take either the suppleme…

This study is testing whether a guided meditation app on a smartphone or tablet can help slow down memory and thinking problems in adults over 60. Researchers want to find the right amount of meditation needed to see benefits and understand which people it helps most. The goal is…

This study is testing a new, automated tool designed to help primary care doctors easily screen older adults for early signs of memory or thinking problems. The tool runs on an iPad and is being tested specifically with 100 Spanish-speaking adults aged 60 and older. The goal is t…

This study is testing a new, brief iPad-based tool called MyCog to help primary care doctors detect early signs of memory loss and dementia more effectively. It focuses on helping older adults from Black, Hispanic/Latino, and low-income communities who often face delays in diagno…

This large study is testing whether helping older adults (70+) lower their blood pressure more than usual can prevent or slow down memory loss and dementia. It will compare a special support program for blood pressure control against regular medical care in 4,000 people. Research…

This study is testing whether a combination of a brain-healthy diet and regular exercise can help prevent memory and thinking problems in Black adults who have high blood pressure. Researchers will compare two groups: one receives home-delivered meal kits, cooking classes, and ex…

This study investigates whether effectively treating obstructive sleep apnea (OSA) in older adults can prevent memory decline and reduce early signs of Alzheimer's disease. Researchers will enroll 200 cognitively healthy adults aged 55-85 with moderate to severe OSA. Participants…

This study is testing whether using a lighter level of general anesthesia during major surgery can help protect older adults' brains. It compares 'light' anesthesia to the usual 'deep' anesthesia to see if the lighter approach reduces post-surgery confusion (delirium) and long-te…

This study is testing a new exercise program designed with and for Black adults aged 45-65 to help them become more physically active. The goal is to see if increasing exercise can help prevent or slow down cognitive decline, which includes problems with memory and thinking. Rese…

This study is testing a program designed to prevent delirium, a common and serious state of confusion after surgery in older adults. Researchers will first test patients' memory before surgery to identify those at highest risk. Those patients and their care teams will then receiv…

This study is testing whether adding immersive virtual reality (VR) videos to a simple chair exercise routine can help improve memory, attention, and thinking skills in older adults with mild cognitive impairment. Researchers will compare a group doing chair exercises with VR vid…

This study is testing a special exercise program designed to help people with diabetic nerve damage. The program combines balance training with mental tasks to see if it improves stability, reduces fall risk, and helps with mild memory problems. Researchers will compare this new …

This study is testing whether an online therapy program can help older adults who have survived a serious hospital stay in the Intensive Care Unit (ICU). The goal is to see if treating depression with this accessible therapy can also slow down feelings of memory and thinking prob…

This study is testing whether a safe, non-invasive brain stimulation technique can help improve motivation and memory in older adults, including those with very early signs of Alzheimer's disease. Researchers will use a device called rTMS to gently stimulate a brain area involved…

This study is testing a new technology-assisted block-building training program for older adults. It aims to see if this fun, game-like activity can help improve memory, thinking skills, hand strength, and dexterity. Researchers will enroll 40 adults aged 65 and older who live in…

This study is testing if a special rideshare service can help older adults and people with memory problems get to their doctor's appointments. It compares a full-service ride where a trained driver helps from door-to-door against a standard curb-to-curb ride. The main goal is to …

This study is testing if a drug called memantine, combined with a supervised exercise program, can help reduce memory and thinking problems ('chemo brain') during breast cancer chemotherapy. It will involve 90 women with early-stage breast cancer who are already reporting mild co…

This study is testing whether playing video games or doing ball tossing exercises can improve hand-eye coordination in older adults with mild cognitive impairment (MCI). Better coordination can help with everyday tasks like dressing, eating, and pouring drinks. Researchers will c…

This study aims to understand how a mild, non-invasive electrical brain stimulation technique might temporarily improve working memory in older adults with mild cognitive impairment. Researchers will compare 55 adults with memory concerns to 55 healthy peers, giving each person b…

This study aims to understand if a person's sleep and daily rhythm patterns before surgery can help predict who might experience confusion (delirium) after a major joint operation. Researchers will observe 150 adults aged 70+ having orthopedic surgery, tracking their sleep with a…

This study aims to find blood markers that can predict which elderly patients are at higher risk of having a stroke or cognitive decline after a TAVR procedure, a common minimally invasive heart valve replacement. Researchers will enroll 542 patients over age 70 and analyze their…

This study aims to understand how being overweight and having blood sugar problems might affect brain development in teenagers. Researchers will follow 117 teens aged 12-17 for nearly two years, comparing brain scans and thinking tests across three groups: normal weight, overweig…

This study aims to build a better model for spotting Alzheimer's disease early by looking at the complete picture of a person's life. Researchers will study 80 patients with memory concerns and their caregivers, combining medical tests with information about mental well-being and…

This study aims to understand how traumatic brain injuries (TBI) in military service members and veterans might lead to thinking problems and vascular dementia. Researchers will follow 300 participants who had a TBI at least three years ago, collecting brain scans, blood tests, a…

This study aims to understand how certain foods, like those in a Mediterranean diet, might help maintain brain health as we age. Researchers will enroll 100 adults over 50 who are at risk for Alzheimer's disease to see how plant compounds affect gut bacteria and, in turn, cogniti…

This study aims to understand why some patients experience memory and thinking problems after surgery to remove a bladder tumor. Researchers will measure blood markers of brain inflammation and give thinking tests to 42 patients before and after their procedure. The goal is to id…

This study aims to understand the early brain changes that happen before noticeable memory problems begin. Researchers will use MRI and PET brain scans, along with memory tests, to track 300 older adults with normal thinking skills over time. The goal is to find the best combinat…

This study aims to find early signs that predict which people with type 2 diabetes are most at risk for developing heart failure or memory problems. Researchers will follow 600 adults with diabetes over time, measuring their heart function, inflammation, and thinking skills. The …