COGNITIVE DECLINE

This study tests whether a daily polyphenol supplement (like berry capsules) can slow cognitive decline in 300 older adults at risk for Alzheimer's. Participants take the supplement or a placebo for 12 months, providing blood, stool, and brain scans. The goal is to see if the sup…

This study tests a goals-based exercise program designed with input from the Black community to help adults aged 45-65 exercise more. Participants will be randomly assigned to different goal-setting and exercise intensity groups. The study tracks activity levels, blood pressure, …

This study tests whether 6 months of supervised aerobic exercise can improve fitness, brain health, and memory in adults aged 65 and older with mild cognitive impairment or early Alzheimer's disease. Participants will exercise, undergo memory tests, and have MRI scans over a year…

This study tests whether a special omega-3 supplement called Lysoveta can deliver more DHA to the brain than standard fish oil. Researchers will measure DHA levels in spinal fluid and blood, along with memory and thinking tests, in 153 older adults with early signs of memory decl…

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium—sudden confusion—and long-term memory problems. About 2,766 participants will be randomly assigned to o…

This study tests an app designed for primary care doctors to quickly screen older adults for early cognitive decline. The app includes risk questions, a symbol matching task, and voice tasks. Researchers will enroll 100 Spanish-speaking adults aged 60 and older to see if the tool…

This study looks at whether combining the MIND diet (a mix of Mediterranean and DASH diets) with aerobic exercise can help prevent memory and thinking problems in Black adults aged 35-75 who have high blood pressure. Participants will be randomly assigned to either receive food d…

This study tests whether helping doctors manage high blood pressure more aggressively can prevent cognitive decline and dementia in adults aged 70 and older. Researchers will use a smartphone app and a clinical decision support tool to guide treatment. 4,000 participants will be …

After surgery, many older adults experience confusion or memory problems, known as delirium. This study tests a program that identifies patients at high risk before surgery and then uses simple steps—like better sleep and hydration—to prevent delirium. The program also educates f…

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking problems (often called 'chemo brain') in women with early-stage breast cancer undergoing chemotherapy. Ninety participants will be split into three groups: mem…

This pilot study tests a 12-week mindful walking program for older South Asian family caregivers (age 45+) who feel stressed and care for someone with cognitive disabilities. Fifty participants will be split into two groups: one does mindful walking with a Fitbit and motivational…

This study tests whether a mobile health program (mPATH) can help low-income older adults who have trouble sleeping and are not very active. Participants will use the program to increase physical activity, and researchers will measure changes in memory and sleep quality. The goal…

This study tests a portable device that plays soft sounds during deep sleep to improve memory and slow cognitive decline in older adults. Sixty participants aged 60-85 with mild memory problems will use the device at home for two 4-week periods. The goal is to see if enhancing sl…

This study is testing a tablet-based meditation game called MediTrain to see if it can help older adults improve their thinking skills and manage stress. Researchers will enroll 4,000 people aged 60 and older to find the best amount of game play needed for benefits. The game adap…

This 8-week study tests whether a daily supplement called Sabroxy® (made from Oroxylum indicum bark) can improve insulin resistance and memory in adults aged 40-80 with mild cognitive impairment and insulin resistance. About 140 participants will receive either Sabroxy® or a plac…

This study tests whether taking broccoli sprout extract daily for 12 weeks can improve memory and thinking in adults aged 55-85 with mild cognitive impairment. One hundred participants will receive either the extract or a placebo. Researchers will measure changes in cognitive tes…

This study tests whether a technology-assisted block training program can improve thinking skills, hand strength, and dexterity in healthy older adults aged 65 and up. Forty participants will use a special block system and be measured on memory, grip, and fine motor skills. The g…

This study tests whether internet-based cognitive behavioral therapy (CBT) can reduce depression and slow cognitive decline in older adults who survived an ICU stay. About 300 participants aged 50+ with depressive symptoms will receive either online CBT or standard depression edu…

This study tests a rideshare service where drivers are specially trained to assist older adults, including those with Alzheimer's or memory problems. The drivers help riders from door to door, even handing them off to clinic staff. The goal is to see if this service reduces misse…

This study tests whether adding immersive virtual reality (VR) 360-degree videos to aerobic exercise can improve memory, attention, and thinking skills in older adults with mild cognitive impairment (MCI). About 34 people aged 60 and older with MCI will either do aerobic exercise…

This study compares two fun activities—video games and ball tossing—to see if they can improve eye-hand coordination in older adults (60+) with mild cognitive impairment. Over 6 weeks, 34 participants will practice either a tapping game or ball exercises. Researchers will measure…

This study is testing whether a mild electrical current applied to the scalp (tDCS) can improve working memory in older adults with mild cognitive impairment (MCI). Researchers will compare the effects of real tDCS versus a sham (fake) version in 110 participants aged 60-95. The …

This study tests whether an AI-driven fitness app and wearable can increase physical activity in adults 65 and older who live alone and have mild cognitive decline. Over six months, 64 participants will use the app and a Fitbit tracker to see if personalized exercise plans and so…

This study tests a 12-month community program (SCIP) for older adults in rural Ecuador. It includes group activities, peer support, and home coaching to reduce loneliness. Researchers will measure changes in social isolation, heart health, memory, and mood in 500 people aged 60 a…

This study looks at whether a community support program called Vefahane helps older adults maintain their thinking skills and quality of life. Researchers will compare 120 people aged 60 and older who take part in activities like exercise, music, and social events with those who …

This study is looking at whether a blood test measuring DNA methylation can predict the risk of silent brain injury in elderly patients undergoing TAVR, a minimally invasive heart valve replacement. About 542 people over age 70 with severe aortic stenosis will have their DNA test…

This study looks at how memory, attention, and other thinking skills change in people who have surgery to remove a meningioma (a type of brain tumor) from the front or side of the brain. Researchers will test cognitive function before surgery and one year later in about 50 adults…

This study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel function in the brains of inactive adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers in 64 participants. Th…

This study tests new methods to improve how dementia clinical trials are run. Researchers want to see if a combined score of thinking and daily function can better measure treatment effects. They will also check if blood proteins can predict who responds to the Alzheimer's drug d…

This study tests whether eating walnuts daily for a week can improve thinking and memory in adults who feel their memory is slipping. Participants will eat either walnuts or a white chocolate bar each day, then switch after a break. Researchers will measure brain function and gut…

This study is following 5,000 middle-aged and older adults in Taiwan who are Tzu Chi volunteers and eat plant-based or vegetarian diets. Researchers want to see if these diets are linked to healthier aging, including better memory, stronger muscles, and lower risk of frailty. Par…

This study looks at whether a gentle, non-invasive brain stimulation technique called rTMS can improve motivation, memory, and brain connections in healthy older adults and people with very early Alzheimer's disease. About 80 participants aged 40-99 will receive daily stimulation…

The TRIAD study is testing whether combining biological markers, psychological tests, and social factors can help diagnose Alzheimer's disease earlier and more accurately. Researchers will follow 80 patients with cognitive decline and their caregivers, collecting data through mem…

This study looks at whether sleep patterns in the two weeks before major orthopedic surgery can help predict delirium (sudden confusion) after the operation. Researchers will ask 150 older adults (70+) to wear a watch that tracks sleep and to give blood samples. The goal is to fi…

This study looks at why some people's thinking and memory get worse as they get older. Researchers will use brain scans and memory tests in 300 healthy adults aged 60 and older to find early signs of Alzheimer's disease. The goal is to better understand how the brain changes over…

This study follows 600 adults with type 2 diabetes who do not yet have heart failure or dementia. Researchers will track their health over time to find early warning signs of heart failure and cognitive decline. The goal is to develop personalized prevention strategies for those …

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and memory tests to see which factors—like insulin resistance or inflammation—are most linked to changes in brain stru…

This study looks at how common memory problems are in older adults (65+) with type 2 diabetes. It then tests a program that combines several lifestyle changes to see if it can prevent or slow down memory loss. About 420 people will take part, and their thinking skills will be com…

This study looks at how natural compounds in fruits and vegetables (called flavonoids) are broken down by gut bacteria and whether those breakdown products help protect the brain. Researchers will give 100 adults aged 50+ at risk for Alzheimer's a special diet and measure changes…

This study looks at whether successfully treating moderate-to-severe sleep apnea can improve memory and reduce biological markers linked to Alzheimer's disease in older adults. About 200 cognitively healthy people aged 55-85 will either receive immediate sleep apnea treatment or …

This study looks at how past traumatic brain injuries (TBI) may affect thinking skills and blood vessel health in 300 active-duty or veteran military members. Researchers will measure substances in the blood linked to blood vessel damage, inflammation, and brain cell loss. They a…

This study looks at whether bladder tumor surgery and general anesthesia can cause short-term memory or thinking problems. Researchers will test 42 adults before and after surgery using simple cognitive tests and blood markers of brain injury. The goal is to understand who might …