COGNITIVE DECLINE

This study tests a device that delivers light and sound stimulation to people with mild to moderate Alzheimer's disease. About 670 participants will use either the active device or a sham (inactive) device for one hour daily over 12 months. The goal is to see if the stimulation c…

This study tests whether a personalized, data-driven hearing rehabilitation program works better than standard care for older adults with hearing loss. About 200 first-time hearing aid users will be randomly assigned to either the new program or usual care. The goal is to see if …

This study tests whether high-dose vitamin D (4,000 IU daily) works better than the standard dose (800 IU) at correcting vitamin D deficiency and slowing memory decline in older adults. Researchers will follow 180 people aged 65-90 with low vitamin D levels for 3.5 years, using b…

This study tests whether a daily soy-based supplement called Equol can slow down stiffening of the arteries, small blood vessel disease in the brain, and memory decline. About 369 adults aged 65-85 will take Equol or a placebo for 2 years. Researchers will measure artery stiffnes…

This study is testing a new automated tool that helps primary care doctors quickly screen older adults for early memory and thinking problems. The tool uses simple symbol matching and voice tasks on an iPad to give a risk score. Researchers hope it will make screening easier and …

This study tests whether a combination of aerobic exercise, cognitive training on a mat, and turmeric (with black pepper) can prevent memory decline in people aged 55-70 who have insulin resistance and notice their thinking skills slipping. Participants will be followed for 24 we…

This study tests whether a digital platform called ToBrainHealth can help people aged 40-75 adopt and stick to brain-healthy habits like exercise, better sleep, and social activities. 120 volunteers will be split into three groups: one gets general advice, another gets personaliz…

This study tests whether an online, coach-assisted program called Luci can help adults aged 50 to 75 improve their lifestyle habits—like diet, exercise, and mental activities—to lower their risk of dementia. About 370 participants with modifiable risk factors will use the program…

This study tests a program called ADL+2.0 designed to prevent or delay cognitive decline in adults aged 60 and older who have memory concerns but no dementia. Participants will receive a mix of cognitive training, exercises, and wellness activities, either remotely or in person. …

This study tests whether a special diet called the MIND diet can help prevent memory loss and dementia in people who have had a stroke. Researchers will compare the MIND diet to usual post-stroke care in 250 adults aged 55 and older. The goal is to see if the diet protects the br…

This study is following older adults for six years to see if using hearing aids can slow down memory loss and thinking problems, and possibly reduce the risk of dementia. It continues a previous 3-year trial where half the participants received hearing aids and the other half rec…

This study tests whether a daily probiotic capsule can improve memory and thinking in adults aged 50 and older. Over 6 months, 110 participants will take either the probiotic or a placebo, then switch. Researchers will also look at how diet and gut bacteria influence the results.

This study tests whether a nutritional product can help improve cognitive function, reduce brain fog, and ease fatigue in adults aged 40 and older. Over 650 participants in the US will take either the active supplement or a placebo for 8 weeks and complete surveys about their thi…

This study looks at whether a drug that increases dopamine (carbidopa/levodopa) can improve thinking speed, walking, and mood in older adults with depression. About 100 people aged 60 and older with depression and slow thinking or walking will take the drug or a placebo. The goal…

This study looks at whether treating chewing problems in older adults can improve memory and thinking. Eighty people aged 65 to 80 with poor chewing ability will get dental work to fix their bite. Researchers will test their memory and brain function before and after treatment to…

This study looks at whether stereotactic radiosurgery (a precise type of radiation) for brain tumors causes thinking or memory problems. About 80 adults with brain metastases or benign meningiomas will take memory tests and quality-of-life surveys before and after treatment. Rese…

This study is creating a large database of information from 250 older adults (65+) having surgery with anesthesia. Researchers will collect questionnaires, blood samples, brain wave recordings, and memory tests before and up to a year after surgery. The goal is to find patterns t…

This study follows 600 people with and without chronic kidney disease (CKD) for up to 4 years to see how memory, thinking, and daily activities change over time. Researchers will compare the two groups and look for risk factors that may lead to cognitive decline, dementia, or str…

This study uses a special PET scan to measure tau protein buildup in the brains of healthy older African Americans. The goal is to learn how these brain changes relate to normal aging versus early Alzheimer's disease. Participants are already part of a long-term study and will ha…

This study was designed to see if eating blueberries (whole or as a powder) for 12 weeks could improve memory and thinking in adults aged 65 and older who have mild memory complaints. The study was withdrawn before any participants were enrolled, so no results are available. It w…

This study looks at how memory and thinking skills change after hip or knee replacement surgery. Researchers will test 505 adults aged 50 and older before and after surgery to see how many experience cognitive decline. The goal is to identify risk factors and better understand ho…

This study aimed to understand how blood pressure changes when standing up affect thinking skills and brain blood flow in people with Parkinson's disease. Researchers planned to compare those with and without orthostatic hypotension (low blood pressure upon standing) using cognit…