COGNITIVE DECLINE

This study follows 629 older adults for 3 years to see if using hearing aids and getting hearing rehab can slow down memory loss and lower the risk of dementia. Participants were already in an earlier trial and now continue with hearing care or a delayed treatment. The goal is to…

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This Phase II trial tests whether high-dose vitamin D (4,000 IU daily) can correct deficiency and slow cognitive decline better than standard doses in 180 older adults aged 65-90. Participants include those with normal thinking, mild impairment, or early Alzheimer's. The study la…

This study tests whether a personalized, data-driven hearing rehabilitation program can improve hearing, thinking, and quality of life in older adults with mild to moderate hearing loss. Two hundred first-time hearing aid users will be randomly assigned to either the new personal…

This study tests whether a daily soy-based supplement called Equol can slow down stiffening of the arteries, small blood vessel damage in the brain, and memory decline. About 369 older adults (ages 65-85) will take Equol or a placebo for two years. Researchers will measure artery…

This large study tests whether a simple iPad-based cognitive test, called MyCog, can help primary care doctors detect early dementia and cognitive impairment in underserved communities. Over 57,000 older adults from 24 clinics will take the test during routine visits. The goal is…

This study tests a new app called RACS that helps primary care doctors screen older adults for early cognitive decline. The app includes risk questions, a symbol matching task, and voice tasks. Researchers will enroll 500 adults aged 60 and older to see if the tool is easy to use…

This study tests whether a personalized lifestyle program can prevent or slow cognitive decline in older adults (ages 60-79) who have risk factors like high blood pressure or lack of exercise. Over 1,200 participants will either receive intensive coaching on diet, exercise, and b…

This study tests whether following the MIND diet for 2 to 3 years can slow cognitive decline and reduce dementia risk in people aged 55 and older who have had an ischemic stroke. The MIND diet combines elements of the Mediterranean and DASH diets, with extra emphasis on leafy gre…

This study tests whether a combination of aerobic exercise, cognitive training, and turmeric (with black pepper) can prevent memory decline in adults aged 55-70 who have insulin resistance and self-reported memory concerns. Participants will follow a 24-week program, repeated aft…

This study tests an online program called Luci that helps people aged 50 to 75 adopt healthier habits to lower their risk of dementia. The program provides educational materials, tips, and a personal coach to guide participants in improving physical activity, diet, and mental eng…

This study tests a program called ADL+2.0 that combines a mobile app with group activities to prevent cognitive decline in adults aged 60 and older who have memory concerns. The program includes cognitive training, exercises, and wellness tips, delivered remotely or in person. Re…

This study tests a nutritional product called Radicle Clarity™ 25_RAM to see if it can improve thinking, memory, and reduce brain fog in adults aged 40 and older. About 650 people in the US will take either the supplement or a placebo for 8 weeks and answer surveys about their co…

This study tests whether a daily probiotic supplement can improve memory and thinking in adults aged 50 and older. Over 6 months, participants take either the probiotic or a placebo for 3 months, then switch. Researchers measure memory tests, brain activity, and gut bacteria to s…

This study follows 350 people who survived a brain bleed (intracerebral hemorrhage) and were part of earlier trials. Researchers will test memory, thinking, and movement skills over time, and collect blood samples to look for signs of ongoing inflammation. The goal is to see if s…

This study is testing whether regular cognitive activities (like video games and book clubs) and physical exercises (like walking and Zumba) can slow down age-related decline in thinking and physical health. Researchers are following 400 healthy Malaysian adults aged 60 and older…

This study looks at whether restoring chewing ability through dental procedures can improve memory and thinking in adults aged 65-80. Eighty participants with chewing problems will be randomly assigned to receive dental rehabilitation either immediately or after a waiting period.…

This study tracks 80 patients with brain tumors (metastases or meningiomas) who receive stereotactic radiosurgery. Researchers use memory tests and quality-of-life questionnaires before treatment and every 3 months for a year to see if and how brain function changes. By comparing…

This study aimed to understand how blood pressure changes when standing up affect thinking abilities and brain blood flow in people with Parkinson's disease. Researchers planned to compare participants with and without orthostatic hypotension (low blood pressure upon standing) us…

Researchers at Stanford are creating a database to better understand why some older adults experience memory or thinking problems after surgery with anesthesia. They will collect information from 250 patients aged 65 and older, including blood samples, brain wave recordings, and …

This study tests whether personalized digital coaching helps people stick to brain-healthy habits like exercise, diet, and sleep. 120 adults at risk for cognitive decline will be assigned to generic education, a digital platform, or the platform plus health coaching. The goal is …

This study uses a special brain scan called Tau PET to look at a protein linked to Alzheimer's disease in healthy older African Americans. Researchers want to learn how this protein builds up and relates to memory changes over time. The goal is to better understand early signs of…

This study follows 600 people with and without chronic kidney disease (CKD) for up to four years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that make thinking and memory worse in CKD patients. Partic…

This study was designed to test whether eating blueberries or taking blueberry powder every day for 12 weeks could improve memory and thinking in older adults with mild memory complaints. It planned to include people aged 65 and older who were overweight and had some memory conce…

This study follows 505 adults aged 50 and older who are having hip or knee replacement surgery. Researchers use a simple online card-game test to measure changes in memory, attention, and thinking before and up to 4.5 months after surgery. The goal is to find out how many people …