COGNITIVE DECLINE

This study is testing whether a daily treatment using special light and sound stimulation can slow the progression of Alzheimer's disease. About 670 people with mild to moderate Alzheimer's will use either the active stimulation device or a look-alike sham device at home for a ye…

This study is testing whether a daily soy-based supplement called Equol can slow down artery stiffening and memory loss in older adults. About 370 people aged 65-85 without dementia will take the supplement or a placebo for two years. Researchers will measure artery health, brain…

This study is following older adults for six years to see if using hearing aids can slow down memory loss and thinking problems, and reduce the risk of developing dementia. It builds on a previous 3-year trial and involves about 629 participants aged 70-84 who have untreated hear…

This study is testing whether a personalized, data-driven approach to fitting hearing aids can do more than just improve hearing in older adults. It aims to see if this tailored method can also help slow cognitive decline and improve quality of life, compared to the standard way …

This study is testing if a medication that increases dopamine, a key brain chemical, can help older adults with depression who also experience slowed thinking and movement. Researchers will give participants either the medication (L-DOPA) or a placebo for short periods to see if …

This study aimed to see if eating blueberries for 12 weeks could improve memory and thinking skills in older adults with mild memory complaints. It planned to compare whole blueberries, blueberry powder, and a placebo pill. However, the study was withdrawn before any participants…

This study is testing a new automated screening tool designed to help primary care doctors quickly identify early signs of memory or thinking problems in older adults. The tool combines simple tasks like symbol matching and voice exercises to create a risk score. Researchers are …

This study is testing whether a personalized online coaching program can help middle-aged and older adults adopt healthier lifestyle habits to lower their risk of future cognitive decline and dementia. The program, called Luci, provides video and chat support from a coach to help…

This study aims to find the best way to help people stick to healthy habits that protect the brain from decline as we age. It will compare three approaches: giving general health advice, providing a personalized digital plan, or combining the digital plan with a human health coac…

This study is testing whether a combined program of physical exercise, cognitive training, and a turmeric supplement can help prevent cognitive decline in adults aged 55-70 who have insulin resistance, a known risk factor for dementia. One hundred participants will follow the pro…

This study is testing a new community program called ADL+ 2.0, designed to help prevent memory and thinking problems in older adults who are at risk. The program uses a mix of smartphone-based brain exercises, physical activities, and wellness tips, which can be done from home or…

This study is testing whether a special virtual reality program can help older adults feel better and think more clearly. The program uses nostalgic scenes from Taiwanese culture to spark memories and includes brain-training games. Researchers will compare 90 older adults who try…

This study is testing whether a new nutritional supplement can improve thinking skills like memory and focus, and reduce feelings of 'brain fog' and fatigue in adults over 40. About 650 participants in the U.S. will take either the real product or a placebo (a look-alike with no …

This study is testing whether a daily probiotic supplement can help improve or slow down memory and thinking problems in older adults. Researchers want to see if the supplement works better for people who eat different types of diets. Over 100 participants will take either the pr…

This study is testing whether digital brain games (on a device) or physical, hands-on puzzles and activities are better at helping older adults with mild to moderate Alzheimer's disease. It involves over 500 participants in Portugal and aims to see which type of activity best sup…

This study aims to understand why people with chronic kidney disease (CKD) often develop memory loss and thinking problems. Researchers are following 600 people, with and without CKD, for up to five years, tracking their cognitive function and taking brain scans. The goal is to i…

This study investigates whether fixing chewing problems in older adults can improve memory and brain health. Researchers will give 80 participants aged 65-80 dental work to restore their chewing ability and then test their memory and scan their brains. The goal is to see if bette…

This study uses special brain scans to look for early signs of Alzheimer's disease in older African American adults who are currently thinking clearly. Researchers want to understand the difference between normal aging and the very early stages of Alzheimer's. Participants get de…

This study aims to understand how vegetarian and plant-based diets affect health as people get older. It will follow 5,000 middle-aged and older volunteers in Taiwan for years, tracking their diet, physical strength, and memory. The goal is to gather evidence to help create bette…

This study aims to understand how often and why patients experience memory and thinking problems after hip or knee replacement surgery. Researchers are following 505 patients aged 50+ to track their cognitive function before and after surgery for several months. The goal is to id…