COGNITIVE DECLINE

This study tested whether levodopa, a drug used for Parkinson's disease, can improve thinking speed, walking, and mood in older adults with depression. Researchers gave 79 participants either levodopa or a placebo for three weeks. The goal was to see if boosting dopamine could he…

This study looked at whether practicing tai chi—a slow, gentle exercise with deep breathing—could lower blood pressure and improve thinking skills in older adults with high blood pressure. Nineteen participants tried a single session and then a 12-week online tai chi program. Res…

This study tested whether early cognitive training and rehabilitation can improve long-term thinking skills in older adults (65+) who experienced delirium during a hospital stay. 283 participants were randomly assigned to receive either the cognitive training program or usual car…

This study tested a program called HOLA (Happy Older Latinos are Active) in 30 Latino adults aged 50+ living with HIV. The program included one-on-one sessions with a community health worker, group walks three times a week, and planning pleasant activities. The goal was to see if…

This study is working on a blood test to help diagnose Alzheimer's disease. Researchers are measuring two specific markers in the blood of 200 people—some with Alzheimer's and some healthy—to see if these markers can reliably tell the difference. The goal is to create a simple, n…

This study tested whether an 8-week course led by a robot (Kebbi) could help prevent cognitive decline in 80 community-dwelling adults aged 65+ with mild cognitive impairment. The experimental group interacted with the robot in small groups, playing board games and learning, whil…

This pilot study tested whether ramipril, a drug typically used for high blood pressure, can help prevent memory loss in people with glioblastoma who are receiving brain radiation. 75 patients took ramipril daily during and after chemoradiation. Researchers measured memory and th…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This study tested a 4-week program called Zinde Zihin ("Fit Mind") in 62 adults aged 65-80 living in nursing homes. The program included brain games, exercise, nutrition advice, and stress management. Researchers measured changes in Alzheimer's risk scores and found that the prog…

This study tested whether taking a daily chicken extract or a peptide supplement for two years could help prevent memory and thinking problems in healthy older adults aged 55 to 75. A total of 276 participants were randomly assigned to receive one of the two supplements or a plac…

This study tested whether a daily program of strength, balance, and walking exercises could help older adults (70+) maintain their physical and mental abilities while in the hospital. 47 participants were split into two groups: one did the exercises each day, and the other receiv…

This study tested whether combining balance exercises with mental tasks (like naming animals) can improve balance and mild memory problems in people with diabetic nerve damage. Fifty adults aged 50 and older with type 2 diabetes and mild cognitive issues took part in 24 sessions …

This study tested whether a supplement called Brain Blossom can improve memory and thinking skills in adults aged 50 to 70. Sixty participants took either the supplement or a placebo for 8 weeks. Researchers measured changes in cognitive tests and self-reported memory and focus.

This study tested a 12-week online program called Brain Health Together for older adults with mild cognitive decline. Participants joined live-streaming exercise and education classes, plus individual coaching, all from home. The goal was to see if the program could improve think…

This study tested whether a virtual reality program featuring nostalgic scenes from Taiwanese culture could improve mood, life satisfaction, and thinking skills in older adults with mild cognitive impairment or mild dementia. Sixty-four participants aged 65 and older were randoml…

This pilot study tested two different computerized brain training programs that also involve light physical activity, like reaching or stepping, in people with multiple sclerosis who have memory or attention problems. The goal was to see if these programs could improve thinking s…

This study tested two types of mental exercises in 514 older adults with mild to moderate Alzheimer's disease. One group used a computer program with brain games, while the other used physical puzzles and memory cards. The goal was to see if these activities could improve thinkin…

This study looked at whether Auri Super Mushroom Daily Gummies can help adults aged 30 and older who struggle with forgetfulness, lack of focus, low energy, and low mood. Over 8 weeks, 35 participants took two gummies each day and completed tests and surveys about their thinking,…

This study tested whether a noninvasive technique called repetitive Transcranial Magnetic Stimulation (rTMS) can improve memory in people with mild cognitive impairment (MCI). 69 participants were randomly assigned to receive active rTMS to one of two brain areas or a placebo tre…

This study tested a goals-based exercise program designed for Black adults aged 45-65 who are not very active. The program aimed to see if it could help people exercise more and learn what they liked or didn't like about it. Researchers worked with a community group to make the p…

This study tested whether a digital tool that scans electronic health records could help find older adults (65+) who might have undetected mild cognitive impairment or Alzheimer's disease. Over 3,400 patients from primary care clinics were identified as high-risk by the tool. Res…

This study looked at whether smell training and/or physical exercise can improve thinking, movement, and quality of life in healthy adults aged 60 and older. About 120 participants were split into four groups: usual care, smell training, exercise, or both. The goal was to underst…

This study tested whether a lifestyle program delivered through a smartphone app could help older adults (ages 60-77) at risk for dementia. 156 participants in four countries were split into two groups: one received a structured program with app support and in-person sessions, wh…

This pilot study explored whether combining lifestyle changes, risk factor management, medications, and supplements could improve movement, thinking, and immune function in aging adults. 23 sedentary adults aged 50-70 took part. The main goal was to see if the study methods were …

This study tested whether a gentle electrical current applied to the scalp at 40 Hz can strengthen brain rhythms linked to memory in healthy adults aged 50-80. Thirty participants received the stimulation while performing a working memory task. The goal was to see if this approac…

This small, early study tested whether drinking beetroot juice (which is rich in natural nitrates) could improve artery stiffness and brain blood vessel function in adults aged 50 to 79. Sixteen participants were randomly given either nitrate-rich or nitrate-depleted beetroot jui…

This study looked at whether regular exercise and speaking two languages can help older adults keep their language skills and thinking abilities. 233 healthy but inactive older adults took part in a 26-week home-based high-intensity interval training program. Researchers measured…

This study tested whether older adults (60+) scheduled for major surgery could complete a set of six brain exercise games on a tablet before their operation. The goal was to see if this was practical in a busy clinic or hospital setting and whether the first-time game scores coul…

This study looked at whether 12 weeks of moderate exercise, three times a week, can improve memory and change gut bacteria in healthy adults aged 45 to 65. Researchers measured memory tasks and analyzed stool samples. The goal was to understand how exercise might help keep the br…

This study looked at whether giving doctors educational materials about a new blood test for Alzheimer's disease helps them make better care decisions. 178 neurologists and dementia specialists in the US participated in virtual patient cases. The researchers measured changes in d…

This study gathered test results from 1,300 healthy adults aged 50 and older to create a reference database for a quick, tablet-based brain function test called BrainCheck. The goal was to establish normal score ranges and check if the test gives consistent results over time. No …

This study looked at how short-term pain impacts the ability to learn and remember new walking patterns in 61 healthy young (18-35) and older (55-85) adults. Researchers measured how well participants learned and retained a new way of walking while experiencing acute pain. They a…

This study tested whether a brain-healthy version of soul food, called the MIND+SOUL diet, is practical and well-liked by older African Americans at risk for heart disease and cognitive decline. Twenty-nine participants aged 55 and older took cooking classes and received dietary …

This study looked at whether shining a special light on the head (called transcranial photobiomodulation) can improve blood flow in the brain and boost thinking skills. 24 healthy adults aged 18 to 80 took part. The goal was to gather information, not to treat or cure any disease…

This small study looked at whether drinking a KETO5 XOGenius beverage every day could improve markers of heart health, thinking skills, and body measurements like weight and waist size. Six healthy adults aged 18 to 50 took part. The goal was to gather early information, not to t…