COGNITIVE DECLINE

This study tests whether eating foods with resistant starch (a type of fiber) can slow down memory loss in people at high genetic risk for cognitive decline. About 70 adults aged 40 and older will either eat high-starch foods or regular starch foods daily. Researchers will track …

This study tests whether minocycline, an antibiotic that reduces brain inflammation, can safely prevent or reverse memory and thinking problems in adults with sickle cell disease. About 30 participants will receive either a low dose, high dose, or placebo for one year. Researcher…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve memory and thinking in people aged 50 to 90 with mild to moderate cognitive decline. Eighty participants will receive six sessions of rTMS over three weeks. Researchers will measure change…

This study tests whether a smartphone app called utmbHealthyBrain is easy for older adults and their caregivers to use. The app includes drawing, Tai-Chi, meditation, and a sharing feature to connect with family. Over six weeks, 40 participants will try the app at home. The goal …

This study looks at whether heart bypass surgery (CABG) causes more long-term memory and thinking problems than a less invasive stent procedure (PCI). Researchers will test 600 patients' brain function before and up to 2 years after their procedure. The goal is to help patients a…

This study is testing a community-based program designed to reduce loneliness and social isolation in adults aged 60 and older living in rural Ecuador. The program includes group activities, peer support, and home coaching over 12 months. Researchers will measure changes in socia…

This study tests whether eating 50 grams of walnuts every day for 24 weeks can improve blood flow and insulin sensitivity in the brain, and boost thinking skills. Researchers will enroll 55 adults aged 45-75 with abdominal obesity, who are at higher risk for cognitive decline. Pa…

This study looks at how short bursts of aerobic exercise might help the brain learn and adapt better in older adults and stroke survivors. About 48 participants will do cycling at different intensities, then complete memory and movement tasks while their brain activity is measure…

This study is testing whether AI-powered fitness trackers and smartphone apps can help older adults (65+) who live alone and have mild memory problems become more physically active. Researchers will give 64 participants a Fitbit and app, and track their activity and well-being ov…