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Pilot study tests new ways to boost brain and body health in aging adults

NCT ID NCT07000734

Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 20, 2026 · Updated 2 times

Summary

This pilot study explored whether combining lifestyle changes, risk factor management, medications, and supplements could improve movement, thinking, and immune function in aging adults. 23 sedentary adults aged 50-70 took part. The main goal was to see if the study methods were practical and well-tolerated, not to prove a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

23 people

The number who actually took part.

Started

Jul 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Participants must be residents of Illinois or Missouri and able to come to St. Louis offices in person. Inclusion Criteria: * Ages 50-70 * Able to come to the research center for testing and intervention visits. * Sedentary (no moderate exercise and no more than 15-minutes per day of light exercise (confirmed via interview with participants)). * BMI≥27 or Body Roundness index ≥6 * Able to provide informed consent. Exclusion Criteria: * Dementia or other clinical neurodegenerative illness (e.g., Parkinson's disease, cerebrovascular disease unless minor eg one lacunar infarct with minimal/no impairment) per self-report or medical records. * Medical conditions that suggest shortened lifespan (such as metastatic cancer), severe/uncontrolled psychiatric disorders or conditions that would prohibit safe participation. * Unable to perform study assessments. * Alcohol or substance abuse within 6 months per self-report or medical records. * Concurrent cognitive training, such as brain-training software, or other interventions expected to affect neuroplasticity. * Any drug that interacts pharmacokinetically, or is contraindicated with study interventions (examples would include high-dose SSRI that should not be combined with vortioxetine) * PI has discretion to exclude potential participants eg if their health status appears either too good or too poor to be amenable to intervention

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Cognitive Dysfunction Sedentary Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Cardiovascular Cognitive decline Immune senescence Motor function Older adults Sedentary behaviors

Contacts and locations

Locations

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

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