CARDIOVASCULAR

This pilot study is testing a 3-month personalized program to see if it can improve physical, mental, and immune health in older adults. The program combines lifestyle changes like exercise and diet with specific medications and supplements. Researchers will enroll about 20 seden…

This study aims to find out if matching the sex of a blood donor to the sex of a critically ill patient improves survival after a transfusion. Over 11,000 adult patients in intensive care units who need a blood transfusion will be randomly assigned to receive blood from a same-se…

This is the first human trial of an experimental one-time treatment called CTX310, which uses CRISPR gene-editing technology. It aims to permanently lower harmful cholesterol and fat levels in the blood of adults whose levels don't respond well to existing medications. The study …

This study is testing a 10-week heart health program designed specifically for home health aides, who often have poor cardiovascular health. The program uses education and lifestyle support from trained 'peer coaches' who are also home health aides. Researchers want to see if par…

This study is testing a new wearable sensor that sticks to the arm to continuously measure lactate, a substance in the body that can signal stress. Researchers want to see if the sensor's readings are as accurate as traditional blood tests taken from patients recovering from plan…

This study aims to develop and improve new portable blood testing devices. Researchers will collect small blood samples from up to 20,000 adults with various health conditions to see if the new portable tests are as accurate as standard lab tests. The goal is to create faster, ea…

This study is testing a new web-based AI tool designed to help detect fatigue and depression in patients with heart conditions. The tool analyzes a person's facial expressions and voice patterns during a short online check-in. Researchers will compare the AI's results to standard…

This study is testing a new tool called 'Breathlessness diagnostics in a Box' (BiaB) to see if it helps general practice doctors diagnose the cause of a patient's breathlessness more quickly than their usual methods. It involves 900 adult patients at clinics in the Netherlands, S…

This study aims to understand how blood pressure changes in the first year after a spinal cord injury and whether a non-invasive spinal stimulation treatment can help control it. It will follow 5 people with recent injuries, testing them about 20-29 times over a year to see if st…

This study aims to understand if drinking more fluids, specifically plain water or non-sugar-sweetened beverages, can improve blood sugar regulation and heart health. Researchers will enroll 144 adults, grouped by normal weight or obesity, to test different fluid intake levels ov…

This study aims to understand why certain powerful cancer drugs (immune checkpoint inhibitors) can shrink tumors but sometimes cause serious heart problems. Researchers will follow 1,200 patients starting this therapy, analyzing their blood and genetics to find clues that predict…

This study aims to understand how a single, long period of sitting affects blood pressure regulation for the next 24 hours. Researchers will measure blood pressure, heart rate, and blood flow in 40 healthy men and women before and after a 2-hour sitting session. They will also te…