CARDIOVASCULAR

This study looks at whether a set of health interventions can help women going through menopause reduce inflammation, improve heart health, slow biological aging, and ease symptoms like hot flashes. Researchers will enroll 200 women aged 45-55 who are in late menopause transition…

This early-phase study tests a single-dose CRISPR treatment (CTX310) designed to edit a gene that controls fat levels in the blood. It is for adults aged 18 to 75 with severe high cholesterol or triglycerides that do not improve with standard medications. The main goal is to chec…

This study aims to improve the heart health of home health aides, a group that often neglects their own health while caring for others. Forty home health aides will take part in a 10-week program called Life's Essential 8, guided by trained peer coaches. The program focuses on he…

This study tests a tool called 'Breathlessness diagnostics in a Box' (BiaB) to see if it helps doctors in primary care find the cause of breathlessness faster than usual care. About 900 adults in the Netherlands, Spain, and Portugal will take part. The tool is used during routine…

This study aims to understand why some people develop heart problems after receiving immune checkpoint inhibitors, a type of cancer treatment. Researchers will analyze blood samples and health records from 1,200 adults starting this therapy. The goal is to find ways to predict an…

This study looks at whether giving critically ill ICU patients blood from a donor of the same sex (sex-matched) improves their chances of survival compared to blood from the opposite sex (sex-mismatched). Over 11,000 adults who need a blood transfusion will be randomly assigned t…

This study looks at how a 2-hour bout of sitting affects blood pressure over the next day in healthy adults aged 18-65. Researchers will measure artery function and blood pressure before, during, and after sitting, and track blood pressure for 24 hours afterward. They also test w…

This study looks at how heart and blood pressure function changes over the first year after a spinal cord injury. Researchers will test whether a non-invasive spinal stimulation technique can help prevent dangerous drops in blood pressure. Five adults with recent spinal injuries …

This study looks at how drinking enough water—either plain or as non-sugary drinks—affects hydration, blood sugar control, and heart health. Researchers will track 144 adults with normal weight or obesity over 8 weeks. The goal is to see if better hydration can lower risks for di…

This study collects blood samples from 20,000 adults with infections, heart disease, blood clots, or kidney disease. Researchers use the samples to develop and fine-tune new diagnostic tests that can give results quickly at the point of care. No treatment or experimental therapy …

This study tests a small wearable device that measures lactate levels through the skin in 50 patients recovering from heart surgery. Researchers compare the device's readings to standard blood tests to see if it is accurate. If successful, the device could reduce the need for fre…

This study is testing a new online platform called Okaya that uses artificial intelligence to detect fatigue and depression in people with heart conditions. Researchers will compare the platform's results to standard questionnaires to see how accurate it is. The study involves 10…