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Can Weight-Loss surgery weaken protein digestion in older adults?

NCT ID NCT06076187

Knowledge-focused Sponsor: Universitaire Ziekenhuizen KU Leuven Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

Researchers are testing whether two types of bariatric surgery, Roux-en-Y gastric bypass and sleeve gastrectomy, reduce how much dietary protein older adults digest. The study compares adults aged 65 and older who had surgery 1 to 10 years ago with younger adults and with people who never had surgery. Using a dual-isotope method, they measure the proportion of protein digested to see if surgery affects the ability to meet protein needs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dual isotope protein digestibility method
What this could lead to
If it works, this could clarify whether older adults who had bariatric surgery absorb enough protein, guiding diet plans to prevent muscle loss.
What could go wrong
This is an observational measurement study, not a treatment trial. It may show differences but not prove why they happen or how to fix them.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

66 people

The number who actually took part.

Started

May 2023

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects with overweight, obesity or after bariatric surgery

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Signed informed consent * Group 1,2,3: Age 65 years or older * Group 4,5,6: Age 18 to 65 years * Group 1,2,4,5: Previous bariatric surgery for obesity 1 - 10 years ago * Group 3,6: No previous weight loss surgery Exclusion Criteria: * Current diagnosis of cancer * Advanced organ failure, including chronic kidney disease Stage 5, liver cirrhosis Stage 3, intestinal failure, heart failure stage D, or chronic obstructive pulmonary disease stage 4. * Immobility * Neuromuscular degenerative conditions * Gastrointestinal conditions including coeliac disease, Crohn's disease, previous resection of the small intestine, gastroparesis * Unable to follow the procedures of the studies due to cognitive impairment such as diagnosed dementia. * Allergy/intolerance to milk, or soy or spirulina

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Conditions

The condition(s) this trial relates to.

malabsorption syndrome Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Bariatric surgery candidate Overweight and obesity Protein malabsorption

Contacts and locations

Locations

  • UZLeuven

    Leuven, Vlaams Brabant, 3000, Belgium

  • Universitaire Ziekenhuizen KU Leuven

    Leuven, Flemish Brabant, 3000, Belgium

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