OVERWEIGHT AND OBESITY

This early-stage study is checking the safety and how the body processes two new injectable drugs, LAE103 and LAE102, in healthy overweight or obese adults and postmenopausal women. Researchers will give single and multiple doses to about 104 participants to see how well they are…

This study is comparing three diets to see which is best for managing heart disease and diabetes risk. It will test a keto diet using canola oil, a traditional high-saturated-fat keto diet, and a standard low-fat diet. About 175 adults who are overweight and at high risk for type…

This study is testing whether following a time-restricted eating schedule combined with high-intensity interval training for one year can reduce body fat and improve metabolic health in adults who are overweight or have obesity. One hundred participants will either follow the rem…

This study is testing a digital program designed to help pregnant women who have overweight or obesity manage their weight gain, activity, and eating habits. 144 participants will use smart scales and activity trackers while receiving weekly coaching, with the goal of staying wit…

This study is testing a weight loss program designed for taxi and ride-share drivers in New York City. It will compare four different support methods—like personal counseling, text messages, and weekly calls—to see which combination works best to help drivers lose at least 5% of …

This is a small, early-stage study to see if a specific protein found in processed egg whites (called IRW) can be absorbed by the body and help manage high blood sugar and high blood pressure. Researchers will give participants smoothies with different protein powders and measure…

This study is testing a community program designed to help Native Hawaiians manage common health conditions like type 2 diabetes, high blood pressure, and high cholesterol. The program combines education on traditional diets and lifestyles with cooking demonstrations. Researchers…

This study is testing if a time-saving workout using whole-body muscle stimulation (WB-EMS) can help lower resting blood pressure and improve other heart health markers. It will involve 42 adults aged 50+ who have mild high blood pressure and are overweight. The goal is to see if…

This study is testing whether adding hands-on cooking classes to a standard weight loss program helps young adults with intellectual disabilities lose more weight and keep it off. Over two years, researchers will compare weight loss, health markers, and daily living skills betwee…

This study aims to improve online weight loss programs for people living in rural areas, where obesity rates are higher but in-person programs are scarce. Researchers will test three types of extra support—weekly video group meetings, personalized feedback from a coach, and indiv…

This study is testing whether using a daily smartphone app can help people with overweight or obesity manage their weight and improve their health. Researchers will compare the app's effectiveness to a standard weight loss program over six months. Participants will use the app da…

This study is investigating whether exercising in the afternoon is more effective than morning exercise at improving blood sugar control in people with pre-diabetes. Researchers will enroll 24 overweight adults to complete a 12-week high-intensity interval training program, assig…

This study is testing whether adding personalized nutrition advice through a smartphone app can improve standard pain rehabilitation. It will involve 200 adults with chronic pain and a higher body weight. Researchers will check if the app is easy to use and if it helps with pain,…

This study is testing whether a 12-week behavioral training program can change how the brain responds to food, reduce the desire to eat, and help with weight control in adults with obesity. Researchers will use brain scans and measure food intake to see if the training works. The…

This study is testing whether a daily gummy containing a special inactivated microorganism (a postbiotic) can help people who are overweight or obese. For 12 weeks, 114 participants will follow general nutrition advice and take either the postbiotic gummy or a placebo gummy. Rese…

This study is testing whether personalized diet advice based on a person's genetic makeup helps people lose more weight and body fat than standard diet advice. It will involve 88 overweight adults in Greece. Participants will receive either DNA-based guidance or general healthy e…

This study is testing whether metformin, a common diabetes medication, can help control asthma in overweight or obese adults whose asthma isn't well-managed with standard inhalers. 100 participants will take either metformin or a placebo pill daily for six months while researcher…

This study is testing whether community cooking classes focused on traditional Native Hawaiian foods can help people better manage diabetes, high blood pressure, and weight. The program involves 1,780 Native Hawaiian adults who will attend quarterly cooking demonstrations and cul…

This study is testing whether the timing of water drinking affects weight loss in adults aged 50 and older who are overweight. Researchers will compare drinking a large glass of water before each main meal to drinking the same total amount spread throughout the day, with both gro…

This study is testing whether eating cottonseed oil three times a week can improve cholesterol levels and other markers linked to heart disease. Researchers will enroll 75 adults who are overweight or have high cholesterol. Participants will consume special shakes with different …

This study is testing whether specific types of exercise during pregnancy can improve the health of overweight or obese mothers and lower the risk of obesity and related health problems in their children. Researchers will follow 300 pregnant women, assigning them to different exe…

This study is testing whether a 10-week parenting support program can help prevent common health problems in low-income Latino infants. Researchers will enroll 260 mothers and their 9-month-old babies to compare the parenting program against a book-sharing program. They will trac…

This study is testing whether a healthy lifestyle program for women with overweight or obesity, started *before* they get pregnant, can help prevent their children from developing obesity. The program includes a special diet, exercise, and mentorship to help women reach a healthi…

This study is testing whether a 3-month telehealth program combining lifestyle coaching and supervised exercise can improve quality of life for people with both COPD and sleep apnea. The program will involve 400 overweight or obese veterans who will be randomly assigned to either…

This study is comparing whether eating fresh watermelon or low-fat cookies has better effects on wellness. Researchers will measure changes in sexual health, skin hydration, gut bacteria, and mood in 80 generally healthy but overweight adults. The goal is to see if watermelon con…

This study is testing whether adding specific balance exercises to regular workouts helps overweight and obese people improve their stability, walking ability, and overall fitness. Forty participants will follow an 8-week exercise program, with half doing standard aerobic and str…

This study aims to understand how poor blood flow in small vessels might contribute to heart and muscle problems in people with type 2 diabetes. Researchers want to see if a 15-week exercise program can improve how the body uses insulin and increase blood flow to the heart and mu…

This study aims to understand a puzzle in early diabetes: why the liver might stop responding to insulin's signal to lower blood sugar but keep making fat. Researchers will give a single dose of a drug called alpelisib or a placebo to healthy adults and adults at risk for type 2 …

This study aims to find out if exercising in the morning or the evening is more effective for weight loss. Researchers will compare how the timing of exercise affects body weight, appetite, and daily energy use in 128 adults who are overweight or obese. Participants will be assig…

This study aims to understand the relationship between the bacteria in a person's mouth, how well blood flows to their muscles, and their overall fitness level. Researchers want to see if these factors are connected, especially in people with heart conditions or who are overweigh…

This study aims to understand how having a higher body weight affects the heart and blood vessels during breathing exercises and short bouts of exercise. Researchers will measure blood pressure in 80 adults while they perform specific breathing tasks and light exercise. The goal …

This study aims to understand why people respond differently to GLP-1 weight loss medications like Wegovy or Ozempic. Researchers will test 30 overweight or obese adults to see if a specific genetic marker influences how much their blood pressure drops and how much weight they lo…

This study aims to understand if taking a special ketogenic supplement drink every evening for four weeks changes how the body burns fuel at night. It will involve 14 healthy but overweight, sedentary adults aged 60-80. Researchers will compare the supplement's effects on metabol…

This early-stage study aims to understand how the body absorbs two different versions of an experimental drug called AMG 133, which is being developed for weight management. It will involve about 340 adults who are living with overweight or obesity. The main goal is to compare ho…