OVERWEIGHT AND OBESITY

This study tests a program called PILI 'Āina to help Native Hawaiians better manage type 2 diabetes, high blood pressure, high cholesterol, and weight. About 1,780 adults who are overweight and have at least one of these conditions will take part. The program focuses on returning…

This study looks at whether combining time-restricted eating (eating only during a set window each day) with high-intensity interval training (short, intense exercise bursts) for 12 months can reduce fat mass in adults who are overweight or obese. About 100 participants will foll…

This study tests whether a diet plan based on your genetic makeup helps you lose more weight and body fat than standard dietary advice. Overweight adults will receive either a personalized genetic-based diet or general healthy eating guidance. Researchers will track changes in we…

This study tests whether a daily postbiotic gummy, combined with nutritional advice, can help overweight or obese adults lose body fat and improve metabolic health. 114 participants will be randomly assigned to receive either the active gummy or a placebo for 12 weeks. The goal i…

This study looks at whether eating cottonseed oil just three times a week can help lower cholesterol and reduce heart disease risk. Researchers will give 75 overweight or at-risk adults meal replacement shakes with different amounts of cottonseed oil for 56 days. They will measur…

This study tests if adding health coaching to regular home visiting services helps pregnant and new mothers lose the weight gained during pregnancy. About 360 women who are overweight before pregnancy will take part. The goal is to reduce heart disease risk by keeping weight off …

This study tests whether combining weight management with a hormone-releasing IUD or hormone pills can reverse a precancerous uterine condition in overweight women who want to keep their fertility. About 172 women aged 18-45 with a BMI of 24 or higher will receive one of four tre…

This study looks at whether drinking water before meals can help adults aged 50 and older with overweight or obesity lose weight. 375 participants will be split into three groups: one drinks water before each meal, one drinks water throughout the day, and one follows a diet witho…

This study tests a digital tool that helps pregnant women with overweight or obesity manage their weight gain. 144 women will use the platform, track weight and activity, and meet weekly with a dietitian. The goal is to see if the tool improves weight control, sleep, eating habit…

This study tests whether using a mobile health app every day for 6 months helps people with overweight or obesity lose weight and improve their health. About 30 adults aged 18-64 with a BMI of 25 or higher will use the app, weigh themselves daily, and check their blood sugar. The…

This study tests whether metformin, a common diabetes medication, can improve asthma control in overweight or obese adults whose asthma is not well-managed by their current inhalers. About 100 participants will take either metformin or a placebo for 24 weeks while tracking their …

This study aims to help overweight or obese taxi and ride-share drivers lose weight. Researchers will test four different approaches, like counseling and text messages, to see which ones work best and are most cost-effective. About 1,785 drivers in New York City will take part. T…

This early-stage study tests a new drug, WVE-007, given as a shot under the skin to help with weight loss. It includes about 296 adults who are overweight or have obesity, some with pre-diabetes or type 2 diabetes. The main goal is to check safety and how the drug moves through t…

This study tests a program called PILI 'Āina for Native Hawaiian adults with type 2 diabetes, high blood pressure, or high cholesterol. About 210 participants will learn to cook and eat traditional Hawaiian foods to improve their diet and health. The goal is to help people better…

This study tests whether adding hands-on cooking classes to a standard weight loss program helps young adults (ages 18-35) with mild-to-moderate intellectual disabilities lose more weight and maintain the loss. The program lasts 24 months and includes 114 participants. Researcher…

This early study looks at whether a specific peptide (IRW) found in egg whites can help manage high blood sugar and blood pressure. About 28 people—some at risk for or with type 2 diabetes, and some healthy—will drink a smoothie with the peptide and have their blood and pressure …

This study aims to find the best way to add human support to an online weight loss program for adults living in rural areas. Over 600 participants will try a 24-week digital program with different combinations of video group sessions, personal coaching calls, and feedback on thei…

This study looks at how different types of keto diets affect heart health and inflammation in adults who are overweight or have prediabetes or type 2 diabetes. Participants will follow either a keto diet with healthy canola oil, a traditional keto diet high in saturated fat, or a…

This study tests two experimental drugs, AZD9550 and AZD6234, for weight loss in people who are overweight or obese, with or without type 2 diabetes. The main goal is to check safety and how the body handles different doses. About 160 adults aged 18 to 75 will take part, receivin…

This study tests whether giving a fecal microbiota transplant to babies born by C-section can improve their gut bacteria and help prevent overweight or obesity later in life. Researchers will track the growth and gut health of 534 infants who receive the transplant shortly after …

This study looks at whether different types of exercise (aerobic, resistance, or both) during pregnancy can improve the health of both mother and child. Researchers will follow 300 overweight or obese pregnant women and their babies for one year after birth. The goal is to find t…

This early-stage study tests a new injectable drug, LAE103, in healthy overweight or obese adults and postmenopausal women. The main goal is to check safety and how the body processes the drug. Some participants will also receive a combination of LAE103 and another drug, LAE102. …

This study tests a mobile app called Diet4painrelief that helps people with chronic pain improve their eating habits. Researchers will enroll 200 adults who are overweight and have chronic pain. Half will get standard pain rehab plus the app, the other half only standard care. Th…

This study tests whether special mental exercises can change how the brain reacts to food, helping people with overweight or obesity eat less and lose weight. About 228 adults aged 18–65 with a BMI of 27 or higher will undergo 12 weeks of behavioral training while researchers mea…

This study looks at whether adding special balance exercises to regular aerobic and strength training can improve balance, walking, and overall fitness in people who are overweight or obese. Forty adults with a BMI between 25 and 35 will be split into two groups: one doing standa…

This study tests a 12-month telehealth program for 400 veterans with COPD, sleep apnea, and overweight. Participants get a self-directed lifestyle plan, supervised exercise sessions, and optional weight management medication. The goal is to improve physical quality of life and re…

This study looks at how your fitness level affects the bacteria in your mouth and the blood flow to your muscles. Researchers will collect mouth swabs, saliva, and have participants exercise on a bike to measure peak fitness. The goal is to understand these connections in people …

This study aims to understand how being overweight or obese affects blood pressure during different breathing tasks. Researchers will measure blood pressure in 80 healthy adults at rest and during exercise. The goal is to learn more about the link between obesity and heart health…

This study tests whether a daily ketogenic supplement taken in the evening for 4 weeks can safely shift overnight metabolism in healthy but overweight adults aged 60-80. Researchers will measure how the body burns fuel during sleep and check muscle cell function. The goal is to u…

This study tests whether a special parenting program (Attachment Biobehavioral Catch-Up) can help low-income Latino children have fewer illnesses, better sleep, and healthier weight. About 260 mothers and their 9-month-old babies will take part. The program focuses on strengtheni…

This study looks at how the hormone insulin controls sugar and fat in the liver. Researchers will give a single dose of the drug alpelisib (or a placebo) to healthy volunteers and people with overweight or prediabetes. By measuring changes in blood sugar and fat production, they …

This study looks at whether eating fresh watermelon can improve sexual health, skin hydration, and gut health compared to eating low-fat cookies. Researchers will enroll 80 generally healthy adults with a BMI between 20 and 40. Participants will eat either watermelon or low-fat c…

This study looks at whether a person's genes (specifically the CAV-1 gene) affect how well GLP-1 weight-loss drugs lower blood pressure and body weight. Researchers will enroll 30 overweight or obese adults to take a GLP-1 drug and measure changes. The goal is to learn why some p…

This study looks at how fat tissue expands and changes when people gain weight over a short period. Researchers will ask 58 overweight adults to eat 30% more calories than usual for several weeks. They want to understand why some people develop health problems like diabetes while…

This study looks at whether exercising in the morning or evening makes a difference in weight loss for people who are overweight. About 128 adults will be assigned to either morning or evening aerobic workouts and tracked for over a year. Researchers will measure changes in weigh…

This study looks at how insulin resistance in small blood vessels contributes to heart and muscle problems in people with type 2 diabetes. Researchers will test whether 15 weeks of exercise training can improve insulin sensitivity and blood flow to the heart and muscles. The stud…

This study is looking at two new blood markers, called SII and SIRI, to see if they can help predict health problems like insulin resistance and fatty liver in people who are overweight or have obesity. Researchers will follow 200 adults for up to 3 years, tracking their diet, li…

This early-phase study looks at whether a natural smell can be detected in the spinal fluid of 32 adults (some obese, some lean) after they inhale it. Participants already scheduled for a spinal tap will also give blood samples and breathe in either the odor or a placebo. The goa…