OVERWEIGHT AND OBESITY

This study tests a new drug combination (AZD9550 and AZD6234) for weight loss in 166 adults who are overweight or obese, with or without type 2 diabetes. The main goals are to check safety, tolerability, and how the drug moves through the body. It is an early-stage trial, so it f…

This study tests an online weight loss program for couples. It includes 762 married or cohabitating partners who are overweight or obese. The program adds four strategies—like joint goal setting and partner feedback—to a core behavioral weight loss plan. The goal is to see which …

This study tests whether whole-body electromyostimulation (WB-EMS), a technology that stimulates muscles with mild electrical pulses, can lower resting blood pressure and improve other heart risk factors in overweight adults aged 50+ with mild hypertension. Over 12 weeks, 28 part…

This study tests a community-based program to help Black and Latino adults with diabetes, prediabetes, high blood pressure, or obesity. Participants receive lifestyle coaching, help connecting to health and social services, and digital skills training. The goal is to see if this …

This study tests whether a diet with more protein (25% of daily calories) helps children aged 7-14 with overweight or obesity lose weight and reduce diabetes risk. Over 10 weeks at a lifestyle camp, one group eats a higher-protein diet while another eats a lower-protein diet, bot…

This study tests a program called ROC+ to help people who are very responsive to food cues lose weight. It compares ROC+ to standard behavioral weight loss programs in 300 adults with overweight or obesity. The goal is to see if reducing reactions to food cues leads to lasting we…

This study looks at whether eating oats for 6 weeks can improve cholesterol, blood pressure, and gut health in people who are overweight or have high cholesterol. Participants will follow a low-gluten diet rich in either oats or rice. Researchers will measure blood fats, inflamma…

This study tests a 6-month online weight loss program designed for Arab adults in Saudi Arabia. Participants are randomly assigned to either the online program or standard hospital-based dietary care. The online program includes 12 Arabic educational sessions and dietitian suppor…

This study looks at whether eating only during certain hours of the day (time-restricted eating) helps adults with obesity lose weight and improve health. About 162 participants will be assigned to either early or late eating windows or standard daily calorie restriction for one …

This study looks at whether a low-carb, high-protein diet can help people with type 2 diabetes control their blood sugar and lose weight better than a standard diabetes diet. About 100 overweight or obese adults with type 2 diabetes will follow one of the two diets for 12 months.…

This study tests whether empagliflozin, a drug used for type 2 diabetes, can improve blood sugar control in 60 overweight or obese adults with prediabetes. Participants take the drug or a placebo for 13 weeks. The goal is to see if the drug helps the body use sugar better and low…

This study tests whether a weight loss program delivered through a patient portal (like a health app) helps overweight adults lose more weight than standard health education. About 250 participants will be randomly assigned to either the active program or a comparison group. The …

This study tests whether a natural supplement called motus can help 100 overweight adults lose weight and body fat over 6 months. Participants take motus daily, track their food and exercise, but are not required to change their diet or workout routine. The goal is to see if motu…

This study tests whether a weight loss program for overweight or obese women (and their partners) before pregnancy can reduce the risk of their child becoming overweight. 240 couples are randomly assigned to either a very low-calorie diet and counseling or no intervention. The ma…

This study tests whether a smartphone app that sets daily step goals can help middle-aged adults (30-70 years old) who are overweight walk more. Participants use a Fitbit and receive adaptive goals to increase light physical activity. The goal is to see if this simple approach ca…

This study tests a 2-year personalized program for overweight children aged 6-7 that includes diet advice, physical activity, psychology, and relaxation techniques. The goal is to reduce their body mass index (BMI) and prevent obesity. Researchers will compare results to a histor…

This study tests whether helping women with overweight or obesity adopt a healthy lifestyle before and during pregnancy can reduce the risk of their children developing obesity. About 360 women planning pregnancy will either receive a tailored program including a low-calorie diet…

This study tests whether giving breastfeeding mothers a natural nutrient called betaine can help prevent rapid weight gain in babies, which is linked to later obesity. About 47 mothers with overweight or obesity will take betaine or a placebo for 3 months while exclusively breast…

This study looks at whether a weight loss program designed for adults who have had a knee replacement can help them lose weight, be more active, and have less pain and better function. About 182 overweight or obese adults who had knee replacement within the last 6 months will tak…

This pilot study aimed to test a parent-only training program for children aged 8-12 with both ADHD and overweight or obesity. Parents would learn weight management skills and strategies to help their child's focus and planning. However, the study was withdrawn before any partici…

This study tested a 24-week weight loss program delivered via video calls for 22 breast cancer survivors who were overweight or obese. The goal was to see if the program was practical and well-liked, and whether it improved quality of life, physical activity, and mood. Participan…

This study tests if a special parenting program (Attachment Biobehavioral Catch-Up) can help low-income Latino children have fewer common illnesses, better sleep, and healthier weight. About 260 mothers and their 9-month-old babies will take part. The program focuses on strengthe…

This study explores whether genetic differences explain why some people benefit more from chili pepper compounds (capsaicinoids) for weight control. Researchers will give supplements to 100 adults with overweight or obesity and measure changes in body fat, appetite, and metabolis…

This study reviews medical records of 300 adults with overweight or obesity who took weight management medications. Researchers want to see how much weight patients lost after 12 months and whether blood sugar and cholesterol improved. No new treatments or visits are required—onl…

This small pilot study looks at how eating foods made with soybean oil or palm oil every day for four weeks changes blood fatty acids and body weight in overweight adults. Sixteen participants will try both oils in a crossover design. The goal is to see if people can stick with t…

This study follows 100,000 Chinese families from before pregnancy through the child's teenage years. Researchers collect health data, biospecimens, and environmental information to understand how parents' exposures affect pregnancy outcomes and child development. The goal is to f…

This study is testing whether a Mediterranean-style low-carb diet that reduces calories can lower insulin and testosterone levels in overweight or obese women with insulin resistance. Eight premenopausal women aged 21-45 will follow the diet to lose about 5% of their body weight.…

This early-stage study tests how two different injection versions of the experimental drug AMG 133 are absorbed by the body in 349 adults with overweight or obesity. Participants receive a single dose, and researchers measure drug levels and safety. The goal is not to treat obesi…

This study looks at how exercise training changes the way muscles process fat and sugar, which is linked to insulin resistance and type 2 diabetes. Researchers will study healthy, lean, and overweight participants before and after a 16-week running or yoga program. The goal is to…

This study follows 70 healthy infants from rural Pakistan over their first two years of life. Researchers will regularly test the babies' gut bacteria to see how it changes and whether it relates to their growth and nutrition. The goal is to understand why some children become ma…

This study tests different ways to reach and enroll women and Black/Latino adults in heart disease research. Participants receive educational text messages about heart health and research opportunities. The goal is to see if these methods increase diversity and trust in clinical …

This study looks at how exercising in the morning versus the evening, and on an empty versus full stomach, changes the way your body burns energy and fat. Researchers will measure these effects in 20 adults with overweight or obesity who are already active. The goal is to better …

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …