OVERWEIGHT AND OBESITY

This study looks at whether a time-restricted eating plan (fasting 16 hours each day) can improve memory and thinking in overweight adults over 65 who have mild memory concerns. Participants either follow the fasting plan or attend healthy aging classes for 24 weeks. The goal is …

This study looks at whether eating oats for 6 weeks can improve cholesterol, blood pressure, and overall well-being in adults who are overweight or have high cholesterol. Researchers will compare the effects of oats to rice by measuring blood fats, inflammation, and gut health. T…

This study tests whether a natural supplement called motus can help overweight adults lose weight and body fat without requiring them to diet or exercise. One hundred participants will take motus daily, track their food and activity, and weigh in weekly for six months. The goal i…

This study tests whether empagliflozin, a drug used for type 2 diabetes, can improve blood sugar control in 60 overweight or obese adults with prediabetes. Participants will take the drug or a placebo for 13 weeks. The goal is to see if the drug helps the body use sugar better an…

This study tests whether a weight loss program delivered through a patient portal can help overweight adults lose more weight than standard education. About 229 participants will be randomly assigned to either an active coaching group or a comparison group. The goal is to see if …

This study looks at whether eating more protein (25% of daily calories) helps children aged 7-14 with overweight or obesity lose more weight than a lower-protein diet. Over 10 weeks, kids follow a calorie-restricted diet and exercise program, then are followed for a year. The goa…

This study tests a program called ROC+ that helps people who are very responsive to food cues lose weight. It compares ROC+ to standard behavioral weight loss programs. 300 overweight or obese adults with high food responsiveness will participate. The goal is to see if ROC+ leads…

This study looks at whether eating only during certain hours of the day (time-restricted eating) helps adults with obesity lose weight and improve health. About 162 participants will be assigned to eat early in the day, late in the day, or simply reduce daily calories for one yea…

This study compares a carbohydrate-reduced, high-protein diet to a standard diabetes diet in 100 adults with type 2 diabetes and overweight. Over 12 months, researchers will measure changes in blood sugar, weight, and fat in the liver and pancreas. The goal is to see if the low-c…

This study compares a 6-month online dietary and lifestyle program to standard hospital-based care for weight loss in Arab adults aged 18-75 with overweight or obesity. Participants will be randomly assigned to either group, and researchers will track changes in body weight, diet…

This study tests a 2-year personalized program to help overweight children aged 6-10 avoid obesity. The program includes education and support tailored to each child's needs. Researchers will measure changes in BMI and compare results to a group of children who did not receive th…

This study looks at whether a smart Fitbit app can help middle-aged adults (30–70 years old, overweight) walk more each day. The goal is to see if increasing light physical activity can protect brain health and lower the risk of Alzheimer's and related dementias. Participants use…

This study looks at whether helping overweight or obese women lose about 10% of their body weight before getting pregnant can lower the chance of their baby being born with too much body fat or becoming overweight in early childhood. About 240 women (and their partners, if they c…

This study tests whether giving betaine supplements to breastfeeding mothers can help prevent rapid weight gain in babies, which is linked to future obesity. About 47 mothers with overweight or obesity will take betaine or a placebo for 3 months while breastfeeding. Researchers w…

This study tests whether helping women with overweight or obesity adopt a healthy lifestyle before and during pregnancy can reduce the risk of their children developing obesity. About 360 women planning pregnancy will either receive a tailored program including a low-calorie diet…

This study tested whether a 24-week weight loss program delivered via video calls is practical and helpful for breast cancer survivors who are overweight. Twenty-two participants completed questionnaires about quality of life, physical activity, and mood before and after the prog…

This study looks at whether a weight loss program designed for adults who have had knee replacement surgery can help them lose weight, be more active, and have less pain and better function. About 182 overweight adults who had a knee replacement within the last 6 months will take…

This early-stage study tests how two different injection forms of the drug maridebart cafraglutide are processed by the body in 349 adults with overweight or obesity. Participants receive a single dose, and researchers measure drug levels and side effects. The goal is to compare …

This study looks at how losing a small amount of weight (5% of body weight) changes insulin and testosterone levels in overweight women with insulin resistance. Researchers will measure these hormones before and after a weight loss diet. The goal is to understand the link between…

This study reviews medical records of 300 adults with overweight or obesity who took weight management medications. Researchers want to see how much weight they lost after 12 months and whether blood sugar and cholesterol improved. No new treatments or visits are needed—all data …

This study looks at how aerobic or yoga training affects the way muscles process fat and sugar, which may influence insulin resistance—a condition that can lead to type 2 diabetes. Researchers will study 64 healthy, lean, or overweight adults before and after a 16-week supervised…

This observational study collects blood, urine, and tissue samples from 500 obese adults to learn more about obesity, weight loss, and why some people regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up to …

This study was designed to test a new parent-led program for children ages 8-12 who have both ADHD and overweight or obesity. The program combined behavioral training with exercises to improve focus and self-control. However, the study was withdrawn before any participants were e…

This study follows 100,000 Chinese families from before pregnancy through the child's teenage years. Researchers will collect health data, blood samples, and environmental information to understand how parents' exposures and health before and during pregnancy affect pregnancy out…

This study looks at how exercising in the morning versus the evening, and on an empty stomach versus after eating, changes the way your body burns energy and fat. Twenty healthy adults with overweight or obesity will complete treadmill tests to measure these effects. The goal is …

This study is testing a program called CONNECT that helps more women and Black and Latino adults learn about and join heart health research. About 1,000 people with heart disease or risk factors like high blood pressure or diabetes will receive text messages with heart health inf…

This study looks at how eating foods made with soybean oil or palm oil for 4 weeks changes blood fats and body weight in overweight adults. Sixteen people will eat three study foods each day. The goal is to see if these oils affect health differently and if people can tell which …

This study follows 70 healthy infants in rural Pakistan from birth to age 2. Researchers will regularly test their gut bacteria to see how diet and health affect growth. The goal is to understand why some children become malnourished or overweight, even after treatment.