OVERWEIGHT AND OBESITY

This study tests whether adding a canine health-literacy module to an existing family lifestyle program helps overweight teens and their parents become more active. The program includes lessons on dog care, behavior, and exercise, along with activity trackers and surveys. Partici…

This study tested a 12-week program for Hispanic mothers with overweight or obesity and their 3-5 year old children. The program included weekly classes on nutrition, exercise, and coping skills, plus exercise sessions. Researchers measured changes in weight, body fat, and health…

This study tested whether eating probiotic-enriched pasta daily for 4 weeks could improve metabolic health and reduce inflammation in overweight and obese adults. Forty healthy men and women with a BMI between 25 and 35 ate either probiotic pasta or regular pasta. Researchers mea…

This Phase 2 study tested an investigational drug called HS-20094 in 200 overweight or obese adults. Participants received either the drug or a placebo injection over several weeks. The main goal was to see how much weight they lost and whether the drug was safe.

This study tested a new daily pill called DA-302168S in 250 overweight or obese adults. The pill works like a natural hormone to control appetite. Researchers measured weight loss and side effects over 16 weeks. The goal is to see if this pill is a safe and effective option for w…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This study looked at whether aerobic exercise can change body composition—like body fat, muscle, water, and bone mass—in overweight and obese boys aged 8 to 12. A total of 80 boys participated, and their body measurements were taken using a special scale. The goal was to see if e…

This study looked at whether eating different amounts of pecans every day for 28 days can improve cholesterol and other heart health markers in adults who are overweight or have high cholesterol. 108 participants were split into groups that ate pecans providing 6%, 13%, or 20% of…

This study looked at whether adding small amounts of cottonseed oil to the diet can improve cholesterol and other heart disease risk factors. 95 adults at increased risk for heart disease drank shakes and ate snacks with different amounts of cottonseed oil for 28 days. Researcher…

This study tested a new drug called Mazdutide to help adults with obesity or overweight lose weight. 179 participants took either the drug or a placebo for about 62 weeks. The main goal was to see how much weight they lost after 32 weeks, with a focus on safety and effectiveness.

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This early-stage trial tested a new injectable drug called CPX101 in 72 healthy volunteers and overweight or obese patients. The main goal was to check safety and how the body processes the drug, with a preliminary look at weight loss. The study is complete, but results are not y…

This study tested a modified adjustable stomach balloon (Spatz4) in 20 adults with a BMI of 27 or higher who had struggled to lose weight with diet and exercise alone. The balloon is placed in the stomach and can be adjusted at week 16 to change its volume. The main goal was to s…

This study tested a new drug called CPX101 in 240 overweight or obese adults without diabetes. Participants received different doses of CPX101 or a placebo by injection for 24 weeks. The goal was to see if the drug helps with weight loss and to check its safety.

This study tested a mobile health lifestyle program for 200 overweight or obese pregnant women in China. Participants used a WeChat account and a Huawei wristband to track diet, exercise, and weight, and received personalized feedback. The goal was to see if this approach could h…

This study tested whether weighing yourself daily with a wireless scale can help adults with obesity manage their weight. About 400 people from primary care clinics took part. They were asked to weigh themselves each day and see their weight trend on the scale's display. The goal…

This study tested whether sending specific motivational messages at just the right moment helps young adults with overweight or obesity meet their daily weight loss goals. Over 200 participants used a smartphone app with a weight loss program, and some received extra messages tar…

This phase 2 study tested whether adding apitegromab (a drug that blocks a muscle-weakening protein) to tirzepatide (a GLP-1 weight-loss drug) helps overweight and obese adults lose fat while keeping lean muscle. 102 participants received either the combination or placebo over 24…

This study looked at whether eating more dairy products for 6 weeks could lower inflammation and other signs of heart disease in overweight adults. Thirty-two people with low dairy intake and at least two other risk factors (like high blood pressure or blood sugar) took part. Res…

This study tested whether adding social gaming (earning points and supporting each other) to a weight loss app helps adults with overweight or obesity and at least 3 risk factors for type 2 diabetes lose more weight over 12 months. About 240 adults used a mobile app to track food…

This early-phase study tested a new drug called TE-8105 in 38 overweight or obese adults without diabetes. The main goal was to see if the drug is safe and how the body processes it. Participants received one or more injections of TE-8105 at different doses. The study is complete…

This study tested whether amiloride, a drug that blocks sodium channels, can improve artery stiffness and blood vessel function in people who are overweight and insulin resistant. 137 men and women (pre- and postmenopausal) took either amiloride or a placebo daily for 6 months. T…

This early-phase trial tested HS235, an experimental drug, in 39 overweight or obese but otherwise healthy adults. The main goal was to check safety and how the drug behaves in the body, not to measure weight loss. Participants received either HS235 or a placebo as a shot under t…

This early-phase trial tested a new drug called HDM1005 in 40 overweight or obese adults. Participants received either the drug or a placebo as a shot under the skin. The main goal was to check safety and how the body processes the drug, not yet to prove it works for weight loss.

This study tested whether taking betaine (a natural substance) for 8 weeks helps overweight and obese women lose body fat and improve their cholesterol levels. Fifty-four pre-menopausal women took either betaine or a placebo daily. Researchers measured body composition, blood fat…

This study tested whether an online family skills training program is practical and well-liked for Black adults trying to lose weight. 21 participants joined with a family member. The program focused on healthy eating and activity habits.

This study tested whether a probiotic called Bifidobacterium breve can help healthy overweight adults lose fat when combined with exercise. About 95 participants took either the probiotic or a placebo for 12 weeks. Researchers measured changes in body fat using X-ray scans to see…

This completed study tested whether eplerenone, a drug that blocks a hormone called aldosterone, improves blood flow and reduces scarring in the heart more than another drug, chlorthalidone, in 79 people with obesity and high blood pressure. Participants took one of the two drugs…

This early study tested a small implant placed under the skin that steadily releases a drug called exenatide, similar to popular weight-loss and diabetes medications. The goal was to check safety and how the drug behaves in the body. Twenty-four overweight but otherwise healthy a…

This completed study tested a dietary supplement called GLP-1 Booster in 69 overweight adults over 26 weeks. The supplement contains extracts from green tea, gardenia, turmeric, and other herbs, and is designed to increase the body's own GLP-1 hormone to help control blood sugar,…

This study tested whether giving extra health coaching to new parents—especially fathers—could help prevent rapid weight gain in babies and reduce obesity risk. Researchers enrolled 657 parents from Massachusetts General Hospital and randomly assigned them to either receive coach…

This study tested a phone-based health coaching program for pregnant women with a higher body mass index. The goal was to help them gain a healthy amount of weight during pregnancy and prevent problems like gestational diabetes and later obesity in both mothers and children. Over…

This completed study tested a program to prevent obesity in mothers and children from pregnancy to age 2. It involved 1,645 families at community health centers in Boston. The program used education, text messages, and provider training to promote healthy eating, physical activit…

This study tests whether time-restricted eating (fasting for 16 hours each day) can improve memory, thinking, and overall well-being in overweight adults aged 65 and older who are worried about their memory. Over 24 weeks, participants either follow the fasting plan or join a hea…

This study looked at whether a 10-week tai chi or multimodal exercise program could improve balance in overweight and obese women. 75 women participated, and researchers measured balance using several tests like standing on one leg and walking quickly. The goal was to find better…

This study tested whether a diet packed with fiber, but lower in calories and sugar, helps control blood sugar after meals and keeps people feeling full. Twenty-four overweight or obese adults ate either the high-fiber diet or a typical Western diet for a short period. Researcher…

This study looked at whether a 7-month low-carb, high-fat (ketogenic) diet could improve symptoms and quality of life in 121 women with lipedema, a chronic fat tissue disorder causing painful leg swelling. Participants followed the diet and were monitored for changes in leg size,…

This study looked at whether eating 3 low-calorie meals a day is better than 5 small meals for blood sugar control and weight loss in people with type 2 diabetes who are overweight or obese. Fifty adults aged 40-70 followed one of the two meal plans for 11 weeks. Researchers meas…

This study looked at whether doing Pilates two or three days per week makes a difference in how well women with overweight or obesity can move, balance, and feel day-to-day. Fifty-one women were randomly assigned to either 12 weeks of Pilates three times a week or 18 weeks of Pil…

This study tested whether a commercial meal replacement weight loss programme could reduce atrial fibrillation (AF) symptoms in overweight adults aged 60-85 with persistent AF. 119 participants were randomly assigned to either the weight loss programme or usual care for 32-36 wee…

This study looked at whether a single session of isometric exercise (like squats and planks) or aerobic exercise (like running) is better at lowering blood pressure in teenagers aged 13 to 17.5 who are overweight or obese. 38 teens were randomly assigned to one type of exercise, …

This study looked at whether a supervised exercise program done twice a week for 12 months could improve physical health and mental well-being in women aged 60 and older. 108 women took part, with half doing the exercise program and the other half continuing their usual activitie…

This study tested a new mindful eating program designed for French adults with overweight or obesity. Fifty-six participants joined group sessions and home exercises to improve their eating awareness. The goal was to see if the program could increase mindful eating and reduce anx…

This study tested two types of time-restricted eating in 103 overweight adults with metabolic syndrome. One group ate all their food within an early 8-hour window, the other within a late 8-hour window. Researchers measured changes in body weight and belly fat to see which timing…

This study tested a sensor worn on eyeglasses that tracks when you eat and sends messages to your smartphone to encourage eating less or eating slower. 43 overweight adults wore the device for one week without any messages, then for two weeks with the messages. The goal was to se…

This study tested whether an oral drug called NG101 can reduce gastrointestinal side effects (like nausea and vomiting) caused by GLP-1 weight-loss medications such as semaglutide. 120 healthy adults with a BMI between 22 and 35 took either NG101 or a placebo for five days, and r…

This study looked at whether replacing non-dairy foods with two servings a day of full-fat or low-fat fermented dairy (like yogurt and cheese) could improve insulin sensitivity and other heart health markers. 110 overweight adults with high triglycerides took part. The goal was t…

This study looked at whether stress hormones (glucocorticoids) released after eating contribute to fat gain in overweight people. Twenty-three overweight men were given either a drug combination that blocks these hormones or a placebo while overeating for a week. Researchers meas…

This study tested whether a protein from amaranth (a plant) could change the gut bacteria in children with overweight or obesity. 56 children took part, and researchers measured their gut bacteria and blood markers. The goal was to learn more, not to treat or cure the condition.

This study looked at how a peanut-based meal affects inflammation and appetite in 17 older adults who were overweight. Participants ate either a high-saturated-fat meal or a peanut meal rich in healthy unsaturated fats. Researchers measured blood markers of inflammation and hunge…

This study looked at whether exercising in the afternoon versus the morning makes a difference in blood sugar levels for people with pre-diabetes. Fifteen overweight adults aged 40-75 completed a 12-week high-intensity interval training program. The main goal was to see if aftern…

This study looked at how a 10-day low-calorie diet, combined with either low or moderate carbohydrate intake, affects exercise ability and health in overweight but otherwise healthy women aged 20-35. Thirty-six participants followed the diet and completed cycling tests and blood/…

This study looked at how a single dose of the drug AMG 133 is processed by the body in people with normal kidney function compared to those with various levels of kidney problems. A total of 44 adults aged 18 to 75 who are overweight or obese took part. The goal was to understand…

This early-stage study tested a tablet made from mulberry twig alkaloids (WH006) in 62 healthy and overweight/obese adults in China. The main goal was to check safety and how the drug moves through the body. Researchers measured side effects and drug levels after single doses, co…

This study looked at whether a before-school physical activity program called BOKS could improve body weight, thinking skills, and quality of life in 188 children aged 5 to 14. The program ran three mornings per week for 12 weeks. Researchers measured changes in BMI, executive fu…

This study tested whether playing online games designed to improve decision-making skills can change people's attitudes about food. Over 600 overweight adults played the games, and researchers measured how fast and accurately they responded. The goal was to see if training the br…

This study tested two ways to help adults with overweight or obesity who struggle to afford healthy food. One group got weekly vouchers to buy produce at a local market; the other got fresh produce delivered to their home along with daily text messages about healthy eating. The g…

This study looked at how a single session of moderate or high intensity exercise changes the makeup of breast milk in women with overweight or obesity. Thirty-two breastfeeding mothers came to the lab on three separate days: two exercise days and one rest day. Researchers collect…

This study looked at how the body processes nutrients and whether that affects food cravings in people with different body weights. Twenty participants drank flavored beverages with sugar and rated how much they liked them. Researchers also measured blood sugar and metabolism. Th…

This study tested whether colchicine, a common anti-inflammatory drug, can change how the brain values effort and reward when making food choices. 59 overweight women with mild inflammation took either colchicine or a placebo daily for 12 weeks. Researchers used brain scans and b…