OVERWEIGHT AND OBESITY

This study tested whether a probiotic called Bifidobacterium breve, taken alongside exercise, helps healthy but overweight adults lose more body fat. About 95 people with a BMI between 25 and 30 took either the probiotic or a placebo for 12 weeks. Researchers measured changes in …

This study tested a virtual health program for African immigrants aged 25-75 who are uninsured and have at least two risk factors like high blood pressure, prediabetes, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over six month…

This study tested whether amiloride, a drug that blocks a sodium channel (ENaC), can improve artery function and reduce stiffness in overweight adults with insulin resistance. The trial included 137 pre- and postmenopausal women and age-matched men. Researchers measured arterial …

This study tested a drug called apitegromab in 102 overweight or obese adults who were also taking a GLP-1 medication (like Ozempic or Wegovy). The goal was to see if adding apitegromab helps preserve lean muscle mass while losing weight. Participants received either the drug or …

This study tested if adding social gaming (like earning points and interacting with others) to a weight loss app helps people lose more weight. 243 adults with overweight or obesity and at risk for type 2 diabetes used the app for 12 months. The goal was to see if the gaming feat…

This study tested a new drug called CPX101 to help overweight and obese people lose weight. 240 adults without diabetes received either the drug or a placebo for 24 weeks. The goal was to see if the drug safely reduces body weight and waist size.

This study tested a new medication called Mazdutide to help adults with obesity or overweight manage their weight. About 179 participants took the drug or a placebo for 62 weeks to see how much weight they lost. The goal was to find out if the drug is safe and effective for weigh…

This study tested a new version of an adjustable stomach balloon (Spatz4) in 20 adults with a BMI of 27 or higher. The balloon is placed in the stomach and can be adjusted after placement to help with weight loss. The main goal was to see if the adjustment procedure works correct…

This study tested a mobile health program for overweight or obese pregnant women to help them gain a healthy amount of weight during pregnancy. Two hundred women used a smartphone app with diet and exercise guidance, plus a fitness tracker, for about six months. The goal was to s…

This study tested a dietary supplement called GLP-1 Booster in 69 overweight adults over 26 weeks. The goal was to see if it helps the body produce more GLP-1, a natural hormone that controls blood sugar, reduces appetite, and supports fat loss. Participants took either the suppl…

This study looked at how eating different amounts of pecans each day for 28 days affects heart health in 108 adults who are overweight or have high cholesterol. Participants ate pecans as part of their diet or stuck to their usual eating habits. Researchers measured changes in bl…

This study tested whether an online family skills training program is practical and well-liked by Black adults trying to lose weight. 21 participants joined with a family member and attended online sessions. The goal was to see if this approach could support healthier eating and …

This study looked at whether eating more dairy products for 6 weeks could lower inflammation and other markers of heart disease in overweight adults. Researchers measured these markers both when participants had fasted and after a high-fat meal. The study involved 32 adults who w…

This study looked at two ways to give free produce to adults with overweight or obesity who struggle to afford healthy food. One group got vouchers to buy produce at a local market, while the other had boxes of fresh fruits and vegetables delivered to their home. Researchers want…

This study tested a 12-week program for Hispanic mothers with overweight or obesity and their 3-5 year old children. The program included nutrition education, exercise, and coping skills training, plus monthly check-ins for 6 months. The goal was to help mothers and children impr…

This study tested whether adults with obesity who weigh themselves every day using an electronic scale can prevent further weight gain. About 400 participants from primary care clinics received a scale and were asked to weigh daily. The goal was to see if this simple habit helps …

This study looked at whether eating 3 low-calorie meals a day helps control blood sugar better than eating 5 small meals in people with type 2 diabetes who are overweight or obese. Fifty adults followed one of two diet plans for 11 weeks. Researchers measured blood sugar changes,…

This early-stage study tested a new injection called HDM1005 in 40 overweight or obese adults. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effects and drug levels …

This early study tested a small implant that releases exenatide, a drug used for weight and blood sugar control, in 24 overweight adults without diabetes. The goal was to check safety and how the drug behaves in the body. Results will help decide if larger studies are needed.

This study tested whether eplerenone, a drug that blocks a hormone called aldosterone, can improve blood flow to the heart and reduce scarring better than a standard blood pressure drug (chlorthalidone) in people with obesity and high blood pressure. About 79 adults took part. Th…

This study tested whether taking betaine, a natural substance, for 8 weeks can help overweight and obese women lose body fat and improve their cholesterol levels. Fifty-four pre-menopausal women with abdominal obesity took either betaine or a placebo daily. Researchers measured b…

This study looked at whether exercising in the afternoon is better than exercising in the morning for improving blood sugar control in people with pre-diabetes. Fifteen overweight or obese adults aged 40-75 with pre-diabetes took part. Researchers measured overnight blood sugar l…

This study tested whether including fathers in parenting support during pregnancy and the first year of life can help prevent childhood obesity and improve health for the whole family. Researchers enrolled 657 parents from diverse backgrounds and randomly assigned them to either …

This study tested a program called Healthy for 2/Healthy for U, which used phone coaching and a website to help pregnant women manage their weight gain. The goal was to prevent too much weight gain during pregnancy, reduce the risk of gestational diabetes, and prevent obesity in …

This study tested a program to prevent obesity in mothers and their children from pregnancy through age 2. It involved over 1,600 families at community health centers in Boston. The program focused on healthy eating, physical activity, sleep, and addressing social factors that af…

This study tested whether a dietary weight loss and behavioral support program could reduce symptoms of atrial fibrillation (AF) in overweight adults aged 60 to 85. Participants were randomly assigned to either the weight loss program or usual care for about 8 months. The main go…

This study tested a new drug called TE-8105 in 38 overweight or obese adults who do not have diabetes. The main goals were to check if the drug is safe and to see how it affects body weight. Participants received one or more doses of the drug, and researchers monitored side effec…

This study tested whether playing online games designed to improve thinking skills (called executive function) can change how people view and choose foods. Over 600 adults with overweight or obesity played these games and researchers measured changes in their reaction times and a…

This study tested a special sensor worn on eyeglasses that tracks eating. For two weeks, 43 adults with overweight received smartphone messages based on the sensor data to help them eat less and slow down. The goal was to see if these real-time tips could change eating behavior.

This study looked at whether a supervised exercise program twice a week for 12 months could improve physical health and well-being in women aged 60 and older. Researchers measured waist size, walking speed, leg strength, and mobility, as well as motivation and psychological well-…

This early-stage study tested a new drug called HS235 in 39 overweight or obese but otherwise healthy adults. The main goal was to check the drug's safety and how the body processes it. Researchers gave different doses to see if it could help with weight management.

This study looked at whether eating only during certain hours of the day (early or late) helps overweight adults with metabolic syndrome lose weight and belly fat. About 100 adults followed either an early or late time-restricted eating plan. Researchers measured changes in body …

This study tested an experimental oral drug called NG101 to see if it could reduce stomach-related side effects (like nausea and vomiting) caused by GLP-1 agonist weight-loss injections such as semaglutide. 120 healthy adults with a BMI between 22 and 35 took either NG101 or a pl…

This study looked at whether doing Pilates two or three days a week makes a difference in how well women with overweight or obesity can move, balance, and feel day-to-day. 51 women completed 36 total Pilates sessions, either over 12 weeks (3 times/week) or 18 weeks (2 times/week)…

This early-phase study tested a new drug called CPX101 in 72 healthy volunteers and overweight or obese patients. The main goal was to check if the drug is safe and tolerable, and to see how the body processes it. Researchers also looked at whether multiple doses could help with …

This study looked at whether a 10-week tai chi or multimodal exercise program could improve balance in overweight and obese women. 75 women participated, and the results showed that both types of exercise significantly improved balance and reduced fall risk. The programs were saf…

This study looked at whether a 7-month low-carb, high-fat ketogenic diet could help women with lipedema, a painful fat disorder that mainly affects the legs. 121 women with lipedema and overweight followed the diet to see if it reduced leg swelling, pain, and improved their quali…

This study tested whether sending specific text messages at just the right moments helps young adults with overweight or obesity meet their daily weight, activity, and diet goals. 255 participants used a mobile weight loss program and received either a message or no message at ra…

This study tested a new mindful eating program designed for French adults who are overweight or have obesity. The program teaches people to pay closer attention to their eating habits and feelings. Researchers measured changes in mindful eating, anxiety, and depression in 56 part…

This study looked at how the body's use of nutrients (like sugar) might affect food cravings and preferences in people with different body weights. Twenty adults with a BMI from normal to obese took part. Researchers measured brain responses and taste preferences to see if people…

This study tested whether adding amaranth protein to the diet could change the gut bacteria of 56 children with overweight or obesity. Researchers measured changes in gut microbes and related health markers. The goal was to learn how a high-quality plant protein might help manage…

This study looked at how a single session of moderate or high-intensity exercise changes the makeup of breast milk. 32 women who were exclusively breastfeeding and had overweight or obesity provided milk samples before, right after, and hours after exercise or rest. Researchers m…

This study tested a before-school exercise program called BOKS in three schools in Revere, MA. About 188 children aged 5 to 14 took part. Researchers measured changes in body mass index, thinking skills, and quality of life to see if the program helped.

This early-stage study tested a tablet made from mulberry twig alkaloids (WH006) in 62 healthy and overweight/obese adults in China. The main goal was to check the drug's safety and how it moves through the body, not to treat obesity. Results will help decide if further studies a…

This study looked at whether isometric exercises (like squats and planks) or aerobic exercises (like running) are better at improving blood pressure in teenagers aged 13 to 17.5 who are overweight or have obesity. 38 teens participated, each doing one type of exercise and having …

This study tested whether eating peanuts, which are high in healthy unsaturated fats, could reduce inflammation after meals in older adults. Seventeen overweight or obese older adults ate two different meals: one with peanuts (low in saturated fat) and one high in saturated fat. …

This study looked at how a low-calorie diet with either low or moderate carbohydrates affects exercise and health in overweight women. Thirty-six women aged 20-35 with a BMI of 25-30 followed a strict diet for 10 days. Researchers measured their exercise capacity, muscle energy s…

This study looked at whether smaller amounts of cottonseed oil can improve cholesterol and other health markers in adults at risk for heart disease. 95 overweight or at-risk adults drank shakes with different doses of cottonseed oil daily for 28 days. Researchers measured changes…

This study looked at whether stress hormones released after eating influence body fat in overweight and obese people. 23 men were given either a drug that blocks these hormones or a placebo during two periods of overeating. The goal was to see if blocking the hormone changes how …

This study looked at whether colchicine, an anti-inflammatory drug, changes how overweight adults make decisions about food. 59 women with a BMI of 27 or higher and mild inflammation took either colchicine or a placebo. Researchers used brain scans and taste tests to see if the d…

This study looked at how a single dose of the experimental drug AMG 133 is processed in people with normal kidneys and those with various levels of kidney problems. 44 adults took part. The goal was to understand safety and how the drug moves through the body, not to treat obesit…