OVERWEIGHT AND OBESITY

This study tests a new drug called AZD9550, alone or with another drug (AZD6234), in 160 adults who are overweight or obese. Some participants also have type 2 diabetes. The main goals are to check safety, side effects, and how the drugs move through the body. This is an early-st…

This study tests whether a daily postbiotic gummy, combined with nutritional advice, can help overweight or obese adults lose body fat and improve metabolism. About 114 participants will be randomly assigned to receive either the active gummy or a placebo for 12 weeks. Researcher…

This study tests whether a diet plan based on your genetic makeup helps you lose more weight and body fat than standard dietary advice. About 88 overweight adults will receive either personalized genetic counseling or general diet tips. Researchers will measure changes in body we…

This study tests if using a mobile health app every day for 6 months helps people with overweight or obesity lose weight and improve their health. About 30 adults aged 18-64 with a BMI of 25 or higher will use the app, weigh themselves daily, and check their blood sugar. The goal…

This study looks at whether drinking water before meals helps adults aged 50 and older with overweight or obesity lose weight. 375 participants will be split into three groups: one drinks water before each meal, one drinks water throughout the day, and one follows a diet without …

This study looks at whether eating cottonseed oil just three times a week can improve cholesterol and other heart health markers in people who are overweight or have high cholesterol. Participants will drink meal replacement shakes with or without cottonseed oil for 56 days and h…

This study is testing a program called PILI 'Āina for Native Hawaiians with type 2 diabetes, high blood pressure, high cholesterol, or overweight. The program promotes traditional Hawaiian diets and cooking to improve health and social connections. About 210 adults will take part…

This study tests a program called PILI 'Āina that helps Native Hawaiians manage type 2 diabetes, high blood pressure, and weight by returning to traditional diets and cooking methods. About 1,780 adults who are overweight and have these conditions will take part. The goal is to i…

This study aims to help overweight or obese taxi and ride-share drivers lose weight through a program that includes counseling, text messages, phone support, and self-monitoring tools. About 1,785 drivers in New York City will take part. The goal is to find the most effective and…

This study tests whether a keto diet using canola oil (healthy fats) is better for heart health than a traditional keto diet high in saturated fat or a low-fat diet. Researchers will measure cholesterol, blood sugar, and inflammation in 175 adults with prediabetes or type 2 diabe…

This study tests whether metformin, a common diabetes drug, can improve asthma control in overweight or obese adults whose asthma is not well-controlled by their current inhalers. About 100 participants will take metformin or a placebo for 24 weeks and have their asthma symptoms,…

This study tests a digital platform that helps pregnant women with overweight or obesity manage their weight gain. 144 women will use the platform, track their weight and activity, and meet weekly with a dietitian. The goal is to see if the tool helps control weight gain and impr…

This study looks at whether combining time-restricted eating (eating only during a set daily window) with high-intensity interval training (short, intense exercise bursts) for 12 months can reduce fat mass in 100 adults who are overweight or obese. Participants do the program fro…

This study is testing whether adding hands-on cooking classes to a standard weight management program helps young adults with intellectual disabilities lose more weight and maintain that loss over two years. Researchers will compare a group receiving the standard program with a g…

This study looks at whether different types of exercise (aerobic, resistance, or both) during pregnancy can lower the risk of obesity in children. About 300 overweight or obese pregnant women will be assigned to an exercise group or a no-exercise group. Their babies will be check…

This study tests whether giving a fecal microbiota transplant to babies born by C-section can improve their gut bacteria and help prevent overweight or obesity. About 534 infants will receive the transplant shortly after birth and be followed for growth differences. The goal is t…

This study looks at whether a specific protein (IRW) from egg whites can help control blood sugar and blood pressure. About 28 people who are overweight or have high blood sugar will drink a smoothie with this protein and have their blood and pressure measured. The goal is to see…

This study aims to find the best way to add human support to a digital weight loss program for adults living in rural areas. About 616 participants will try a 24-week online program with different combinations of group video sessions, personalized feedback, and coaching calls. Th…

This study tests a 12-month telehealth program for 400 veterans with COPD, sleep apnea, and overweight. Participants get a self-directed lifestyle plan, supervised exercise sessions, and optional weight management medication. The goal is to improve physical quality of life and re…

This study is testing a mobile app called Diet4painrelief that gives personalized nutrition advice to people with chronic pain who are also overweight. About 200 adults will either get standard pain rehab or rehab plus the app. Researchers will check if the app helps improve diet…

This early-stage study tests the safety and tolerability of an experimental drug called LAE103 in healthy overweight or obese adults, and also in healthy postmenopausal women. Researchers will give single or multiple doses to see how the body processes the drug and if it causes s…

This study looks at whether adding special balance exercises to regular aerobic and strength training can help overweight people improve their balance, walking, and overall fitness. Forty adults with a BMI between 25 and 35 will be split into two groups: one does standard workout…

This study tests whether a time-saving, joint-friendly muscle stimulation technology (whole-body electromyostimulation) can lower resting blood pressure and improve other heart-related risk factors in people with mild high blood pressure and overweight. Researchers will compare t…

This study aims to understand how insulin controls sugar and fat production in the liver, comparing healthy adults to those at risk for type 2 diabetes. Participants will receive a single dose of the drug alpelisib or a placebo during two overnight hospital stays. Researchers wil…

This study will follow 200 adults with overweight or obesity for up to 3 years to see if two blood inflammation markers (SII and SIRI) can predict metabolic problems like insulin resistance and fatty liver, and how well people respond to weight-loss treatments. Participants will …

This study looks at whether exercising in the morning or evening makes a difference in weight loss for people who are overweight. Researchers will track 128 adults over 13 months, measuring weight, body fat, sleep, and eating habits. The goal is to find out if timing your workout…

This study looks at how your fitness level relates to the bacteria in your mouth and how well blood flows to your muscles. Researchers will collect mouth swabs, saliva, and have participants do a cycling test. The goal is to understand these connections in people with heart failu…

This study looks at whether a special ketogenic drink taken every evening for 4 weeks can change how the body burns energy overnight in healthy but overweight seniors aged 60-80. Researchers will measure metabolism and muscle cell function. The goal is to understand if this suppl…

This study looks at how a common weight-loss drug (GLP-1) works in people with different versions of a gene called CAV-1. Researchers want to see if the gene affects how much weight and blood pressure drop. About 30 overweight or obese adults will take the drug and be monitored. …

This study looks at how insulin resistance in type 2 diabetes reduces blood flow to muscles and the heart, leading to poor exercise ability. Researchers will test if 15 weeks of exercise training can improve insulin sensitivity and heart function. The study involves 150 sedentary…

This study looks at whether eating fresh watermelon can improve sexual health, skin hydration, and gut health compared to eating low-fat cookies. Researchers will enroll 80 adults who are overweight or obese but otherwise healthy. Participants will eat either watermelon or low-fa…

This study looks at how fat tissue grows and changes when people gain weight over a short period. Researchers want to understand why some people develop health problems like metabolic syndrome or diabetes when they gain weight, while others do not. About 58 overweight adults will…

This study looks at how different behavioral programs that change the way people think about food affect brain activity, eating habits, and body weight. About 228 adults with a BMI of 27 or higher will take part. Researchers will use brain scans and food intake tests to see what …

This study tests whether an attachment-based parenting program (ABC) can improve health outcomes like common illnesses, sleep, and weight in low-income Latino children. 260 mothers and their 9-month-old babies will be randomly assigned to either the ABC program or a home reading …

This study aims to understand how being overweight or obese changes the way your heart and blood vessels respond during different breathing exercises and physical activity. Researchers will measure blood pressure in 80 healthy adults while they rest, exercise, and perform special…