OVERWEIGHT AND OBESITY

This study compares two blood sugar targets for overweight or obese women with gestational diabetes. One group aims for stricter goals (fasting under 90 mg/dL, after meals under 120 mg/dL), while the other follows standard targets (fasting under 95 mg/dL, after meals under 140 mg…

This study tests if adding health coaching to regular home visiting services helps pregnant and new moms lose weight gained during pregnancy. The goal is to reduce long-term risks for heart disease and diabetes. Researchers will enroll 360 women who are overweight before pregnanc…

This study is for overweight or obese women aged 18–45 with atypical endometrial hyperplasia, a precancerous condition of the uterine lining. Participants will receive either a levonorgestrel-releasing IUD (Mirena) or megestrol acetate pills, combined with a weight management pro…

This early-stage study tests a new drug, WVE-007, given as a shot under the skin to help with weight loss. It includes about 296 adults who are overweight or have obesity, some with pre-diabetes or type 2 diabetes. The main goal is to check safety and how the drug moves through t…

This study tests a program called PILI 'Āina that helps Native Hawaiians manage type 2 diabetes, high blood pressure, high cholesterol, and overweight. About 1,780 adults will take part in cooking demonstrations and learn how to eat more traditional Hawaiian foods. The goal is to…

This study tests a program called PILI 'Āina that combines lifestyle lessons, home gardens, and cooking classes to help Native Hawaiians manage type 2 diabetes, high blood pressure, and obesity. About 210 overweight or obese Native Hawaiian adults with these conditions will take …

This study tests whether a daily postbiotic gummy, combined with healthy eating advice, can help overweight or obese adults lose body fat and improve metabolic health. Over 12 weeks, 114 participants will be randomly assigned to receive either the postbiotic or a placebo gummy, a…

This study compares two types of diet counseling for weight loss: one based on your genetic makeup and the other on standard healthy-eating guidelines. About 88 overweight adults will receive personalized advice and be followed to see which approach leads to greater fat loss and …

This study aims to help overweight or obese taxi and ride-share drivers lose weight through a combination of counseling, text messages, phone support, and self-monitoring tools. Researchers will enroll about 1,785 drivers in New York City to find out which parts of the program wo…

This study looks at whether eating cottonseed oil just three times a week can help lower cholesterol and reduce heart disease risk. Researchers will give 75 overweight or at-risk adults meal replacement shakes with different amounts of cottonseed oil for 56 days. They will measur…

This early-stage study tests the safety and tolerability of a new injectable drug called LAE103 in healthy overweight or obese adults, and in healthy postmenopausal women. Researchers will also test LAE103 combined with another drug, LAE102. The goal is to find out if the drug is…

This study tests a digital platform called HMZ 2.0 that helps pregnant women with overweight or obesity manage their weight gain. 144 women will be randomly assigned to use the platform or receive standard pregnancy advice. The platform tracks weight, activity, and eating, and of…

This study tests whether metformin, a common diabetes medication, can improve asthma control in overweight or obese adults whose asthma is not well-managed by their current inhalers. About 100 participants will take either metformin or a placebo for 24 weeks while tracking their …

This study compares two types of keto diets—one high in saturated fat and one high in unsaturated fat (like canola oil)—against a standard low-fat diet in 175 adults who are overweight or have prediabetes or type 2 diabetes. Researchers will measure changes in cholesterol, blood …

This study aims to find the best way to help people living in rural areas lose weight using a digital program. Over 600 adults with overweight or obesity will test different combinations of human support, such as group video chats, personal coaching calls, and feedback on their p…

This study looks at whether eating only during a set window each day combined with short, intense exercise can help overweight adults lose fat and improve health markers like blood sugar and cholesterol. One hundred participants will follow this routine remotely for 12 months, wi…

This study looks at whether drinking water before meals helps people aged 50 and older with overweight or obesity lose weight. 375 participants will be split into three groups: one drinks water before each meal, one drinks water throughout the day, and one follows a diet without …

This study tests whether adding hands-on cooking classes to a standard weight loss program helps young adults (18-35) with mild-to-moderate intellectual disabilities lose more weight and keep it off. Over 24 months, 114 participants will either follow a healthy eating plan with c…

This study tests whether using a mobile health app every day for 6 months helps people with overweight or obesity lose weight and improve their health. About 30 adults aged 18-64 with a BMI of 25 or higher will use the app, weigh themselves daily, and check their blood sugar. The…

This study looks at whether different types of exercise (aerobic, resistance, or both) during pregnancy can improve the health of both mother and child. Researchers will follow 300 overweight or obese pregnant women and their babies for one year after birth. The goal is to find t…

This study tests whether giving a fecal microbiota transplant to babies born by C-section can improve their gut bacteria and help prevent overweight or obesity later in life. Researchers will track the growth and gut health of 534 infants who receive the transplant shortly after …

This study tests whether early time-restricted eating (eating only during a set morning window) helps postpartum women with overweight lose weight and improve heart health. Sixty women 6-16 weeks after a healthy pregnancy will either follow this eating schedule or eat normally fo…

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…

This study is testing a mobile app called Diet4painrelief that helps people with chronic pain improve their eating habits. About 200 adults with chronic pain and a BMI of 25 or higher will take part. The goal is to see if the app can reduce pain, improve sleep, and make daily lif…

This study tests whether special behavioral exercises can change how your brain reacts to food, helping you eat less and lose weight. About 228 adults with a BMI of 27 or higher will participate. Researchers will use brain scans and food diaries to see if these exercises work.

This study tests whether adding special balance exercises to a standard workout of walking and strength training can improve balance and physical fitness in overweight and obese adults. Forty participants will be randomly assigned to either a standard exercise program or one that…

This study tests a 12-month telehealth program that combines healthy eating, exercise coaching, and remote pulmonary rehab for 400 overweight veterans with both COPD and obstructive sleep apnea. Participants use a Fitbit and app to track progress, with the goal of improving physi…

This study looks at how being overweight or obese changes blood pressure during different breathing tasks and exercise. Researchers at Florida State University will measure blood pressure in 80 healthy adults at rest and during aerobic and breathing muscle tests. The goal is to b…

This study is testing whether mixed reality (MR) versions of common mobility tests, like the Timed Up and Go test, are as accurate and reliable as the traditional versions for overweight and obese adults. About 119 participants will perform both MR and conventional tests using a …

This study looks at two blood inflammation markers, SII and SIRI, to see if they can help predict metabolic problems like insulin resistance and fatty liver in people who are overweight or have obesity. Researchers will follow 200 adults for up to 3 years, tracking their diet, la…

This early-phase study tests whether a natural odor, when inhaled, can be detected in the cerebrospinal fluid (the fluid around the brain and spine) within 30 minutes. 32 lean and obese adults who are already scheduled for a spinal tap will sniff either the odor or a placebo. The…

This study looks at how fat tissue changes when people gain weight from overeating. Researchers will ask 58 overweight adults to either maintain their weight or eat 30% more calories for a short time. By tracking fat cell growth and other changes, they hope to understand why some…

This study looks at how the hormone insulin controls blood sugar and fat in healthy adults and those at risk for type 2 diabetes. Researchers will give participants a single dose of a drug called alpelisib, which blocks some of insulin's effects, to see if the liver can still mak…

This study looks at how exercise affects insulin resistance and heart function in people with type 2 diabetes. Researchers will have 150 participants do 15 weeks of cardiovascular exercise, 3 times a week. They will measure changes in oxygen use and insulin sensitivity to see if …

This study tests whether taking a ketogenic nutritional supplement every evening for 4 weeks can change how the body burns energy overnight and affect muscle health. Researchers will study 14 healthy but overweight adults aged 60-80 who are not very active. Participants will eith…

This study looks at whether eating fresh watermelon can improve sexual health, skin hydration, and gut health compared to eating low-fat cookies. Researchers will enroll 80 generally healthy adults with a BMI between 20 and 40. Participants will eat either watermelon or low-fat c…

This study looks at whether exercising in the morning or evening makes a difference in weight loss for people who are overweight. Researchers will track weight, body fat, sleep, and eating habits in 128 adults over 13 months. The goal is to find out if timing your workouts can he…

This observational study looks at how fitness level relates to bacteria in the mouth and blood flow to muscles. Researchers will collect mouth swabs, saliva, and blood samples, and measure exercise capacity in 70 adults with heart failure, peripheral artery disease, or overweight…

This study looks at whether a person's genes (specifically the CAV-1 gene) affect how well GLP-1 weight-loss drugs lower blood pressure and body weight. Researchers will enroll 30 overweight or obese adults to take a GLP-1 drug and measure changes. The goal is to learn why some p…