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Can weight management plus hormones reverse precancerous uterine changes and preserve fertility?

NCT ID NCT05316493

Recruiting now Disease control Sponsor: Xiaojun Chen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for overweight or obese women aged 18–45 with atypical endometrial hyperplasia, a precancerous condition of the uterine lining. Participants will receive either a levonorgestrel-releasing IUD (Mirena) or megestrol acetate pills, combined with a weight management program including diet and exercise guidance. The goal is to see if this combination can reverse the abnormal cells and allow women to later become pregnant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
levonorgestrel intrauterine system (Mirena) or megestrol acetate oral tablet
What this could lead to
If successful, this approach could help obese women with precancerous endometrial changes avoid hysterectomy and preserve their ability to have children.
What could go wrong
This is an early-phase study with no placebo group, so results may not be definitive. The treatments have side effects, and not all participants will respond or achieve pregnancy.

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Conditions

The condition(s) this trial relates to.

atypical endometrial hyperplasia Endometrial Hyperplasia infertility disorder Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATYPICAL ENDOMETRIAL HYPERPLASIA FERTILITY ISSUES OVERWEIGHT AND OBESITY

Contacts and locations

Locations

  • Obstetrics and Gynecology Hospital of Fudan University

    RECRUITING

    Shanghai, China

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