Keto showdown: which fat is better for your heart and blood sugar?

NCT ID NCT05681468

Recruiting now Disease control Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This study compares two types of keto diets—one high in saturated fat and one high in unsaturated fat (like canola oil)—against a standard low-fat diet in 175 adults who are overweight or have prediabetes or type 2 diabetes. Researchers will measure changes in cholesterol, blood sugar, and inflammation over 6 months to see which diet offers the best heart and metabolic benefits. Participants receive nutrition counseling and are randomly assigned to one of the three diets.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketogenic diet (high fat, low carbohydrate) with either saturated or unsaturated fat sources, compared to a low-fat diet
What this could lead to: If successful, this study could show that a keto diet with healthy unsaturated fats is better for heart health and blood sugar control than a traditional keto or low-fat diet.
What could go wrong: This is a diet study, not a drug trial, so results depend heavily on participants sticking to the diet. It is also relatively small and short-term, so findings may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight prediabetes syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 2 OVERWEIGHT AND OBESITY PREDIABETES

Contacts and locations

Locations

University of Alberta
RECRUITING

Edmonton, Alberta, T6G 2E1, Canada

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