PREDIABETES

This study compares two lifestyle programs for people with type 2 diabetes or prediabetes: one using a ketogenic diet and the other a low-fat diet. Over 12 months, researchers will track changes in weight, blood sugar, blood pressure, and heart health. The goal is to see which di…

This study looks at whether eating avocados regularly can improve how the body handles fats and sugar in people with prediabetes and insulin resistance. About 82 adults aged 40-70 with high triglycerides and insulin resistance will eat avocados as part of their daily diet. Resear…

This study tests whether giving people access to healthy foods, personalized dietitian coaching, and a home blood pressure monitor can help Black and Hispanic adults with high blood pressure (and often diabetes) get their numbers down. About 100 participants will be randomly assi…

This study offers a free 3-month diabetes education program at a local faith-based organization for adults with diabetes or prediabetes in Jefferson County, Alabama. Participants attend group sessions on diet, exercise, and coping, and are paired with a community health worker fo…

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This study looks at whether adding menopausal hormone therapy to a GLP-1 drug (semaglutide) improves blood sugar control in early postmenopausal women who have or are at risk for type 2 diabetes. About 96 women with menopausal symptoms and a BMI of 27 or higher will be enrolled. …

This early-stage study tests a new drug, WVE-007, given as a shot under the skin to help with weight loss. It includes about 296 adults who are overweight or have obesity, some with pre-diabetes or type 2 diabetes. The main goal is to check safety and how the drug moves through t…

This study tests whether walking at least 10,000 steps a day and avoiding snacks after 8 p.m. can improve metabolic health in teenagers aged 12-18 with prediabetes. Eighty participants will be randomly assigned to either the lifestyle program or standard care for 8 weeks. The mai…

This study investigates whether continuous glucose monitor (CGM) data can pinpoint the time of day when a person with prediabetes experiences the largest blood sugar spikes after eating. Participants wear a CGM and activity tracker for 10 days to identify their personal 'vulnerab…

This study tests whether eating all meals within a 9-hour window each day for 12 weeks can improve insulin sensitivity and other heart health markers in 100 adults with obesity and prediabetes. Participants will be randomly assigned to either a 9-hour eating window or a 14-hour w…

This pilot study tests whether providing culturally appropriate food bundles and easy-to-read recipes can help adults with type 2 diabetes who face food insecurity. About 25 participants will receive food bundles and education, then complete surveys at 3 and 6 months. The goal is…

This study looks at whether eating pecans instead of snacks high in bad fats and sugar can improve blood sugar and heart health in people with prediabetes. About 147 adults aged 25-65 with prediabetes will either eat 1.5 ounces of pecans daily for 16 weeks or stick to their usual…

This study tests a computer program that alerts doctors and nurses when hospital patients have dangerously high or low blood sugar. The tool suggests care steps to improve glucose control. Researchers will track over 15,000 adults across multiple hospitals to see if the tool redu…

This study tests whether intermittent fasting can improve how the body releases insulin in people with prediabetes or early type 2 diabetes. About 200 adults with a BMI between 25 and 40 will follow a 4-week fasting plan or a control diet. The goal is to see if fasting can boost …

This study tests a new digital tool called P3-EX that helps doctors create personalized exercise plans for patients with heart disease risk factors like high blood pressure, diabetes, and obesity. Researchers will recruit 24 doctors and 48 patients to compare the new tool with a …

This study tests a program that gives fresh fruits and vegetables to Native American adults aged 55 and older who face food insecurity and have type 2 diabetes or are at risk. Participants receive vouchers to buy healthy food at local centers, along with nutrition education. The …

This study tests an investigational drug called MOTS-c in 120 adults with prediabetes and overweight or obesity. The goal is to see if 12 weeks of treatment can improve how the body uses insulin, compared to a placebo. All participants also receive standard lifestyle advice. The …

This study tests whether eating peanuts and peanut products daily for six months can improve blood sugar, blood pressure, thinking skills, and gut health in people with prediabetes. Researchers will enroll 72 adults from diverse racial backgrounds. Participants will eat different…

This study tests a program called Regulation of Cues (ROC) in 30 Latina women with prediabetes and obesity. The program teaches awareness of eating triggers and coping strategies to reduce weight and prevent type 2 diabetes. Researchers are first checking if participants find the…

This study tests whether adding SMS reminders with diet and exercise advice to a standard lifestyle program helps people with prediabetes lose more weight. 300 participants in Réunion will be split into two groups: one gets the standard program alone, the other also receives 72 t…

This study tests whether empagliflozin, a diabetes drug, can improve left atrial function in 66 people with paroxysmal atrial fibrillation, high blood pressure, and abnormal glucose metabolism. The goal is to see if it can prevent heart failure. Participants will be randomly assi…

This study tests whether a daily collagen supplement called Nextida GC-B can improve blood sugar control in adults with normal blood sugar or prediabetes. Over 90 days, researchers will measure how the body handles sugar after meals and track changes in HbA1c. Sixty participants …

This study tests a program called PILI 'Āina that helps Native Hawaiians manage type 2 diabetes, high blood pressure, high cholesterol, and overweight. About 1,780 adults will take part in cooking demonstrations and learn how to eat more traditional Hawaiian foods. The goal is to…

This study looks at whether eating three servings of dairy each day (like milk, yogurt, and cheese) can help overweight teens (ages 15-18) and seniors (ages 60-80) improve their body weight, body composition, and blood sugar levels over six months. Participants are randomly assig…

This study tests a program called PILI 'Āina that combines lifestyle lessons, home gardens, and cooking classes to help Native Hawaiians manage type 2 diabetes, high blood pressure, and obesity. About 210 overweight or obese Native Hawaiian adults with these conditions will take …

This pilot study compares two approaches to reduce type 2 diabetes risk in 40 overweight adults with prediabetes. One group follows the standard Diabetes Prevention Program (DPP) focusing on diet and exercise. The other group uses an enhanced version (DPP++) that also includes a …

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce food insecurity and improve insulin resistance. About 200 adults with HIV from a clinic…

This small pilot study is testing whether eating Greek bottarga (grey mullet fish roe) every day can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare the effects of bottarga against a dairy pro…

This study tests whether a liquid supplement made from carob extract can improve blood sugar control in people with prediabetes. Thirty adults with prediabetes will take either the carob supplement or a placebo before meals for a period of time. Researchers will measure changes i…

This study tests whether giving a healthy food voucher to people with type 2 diabetes or prediabetes who have low income can improve their blood sugar control. About 390 participants will be randomly assigned to receive the voucher or not. The main goal is to see if hemoglobin A1…

This phase 2 trial is testing whether mirabegron, a drug currently used for overactive bladder, can improve glucose tolerance and activate brown fat in people with prediabetes. Researchers will enroll 65 adults with a BMI of 27-45 and prediabetes. Participants will take mirabegro…

This study tests whether a mobile app called PortionSize Ed can help recent stroke survivors who also have prediabetes or type 2 diabetes follow a Mediterranean-style diet. Forty adults aged 30 to 65 will be split into two groups: one gets the full app with dietitian support, the…

This study compares two types of keto diets—one high in saturated fat and one high in unsaturated fat (like canola oil)—against a standard low-fat diet in 175 adults who are overweight or have prediabetes or type 2 diabetes. Researchers will measure changes in cholesterol, blood …

This study tests whether meal replacement products can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and lower blood sugar. Twenty participants will use meal replacements and be monitored for weight loss and blood sugar changes. The goal is to s…

This study tests whether watching virtual reality (VR) cycling videos can produce exercise-like benefits in 48 sedentary adults with prediabetes or high blood pressure. Participants will either do 20 minutes of real cycling or watch VR cycling, and researchers will measure change…

This study tests whether a special high-intensity interval training (HIIT) program can improve heart health in school-age children who are at high risk for cardiovascular disease. The program involves short bursts of intense exercise, done several times a week. Researchers will t…

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes better manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals…

This study compares personalized oral hygiene advice from an AI app versus a human dentist in 148 adults with prediabetes and gum disease. The goal is to see if AI can improve gum health and blood sugar levels as well as a dentist. Participants will have their gums and blood suga…

This study compares two newer diabetes drugs, semaglutide and dapagliflozin, against the standard drug metformin in 300 people with pre-diabetes and coronary artery disease. The goal is to see which drug best slows or reverses the buildup of plaque in heart arteries over 24 month…

This study tests whether wearing a continuous glucose monitor (CGM) alongside lifestyle changes can improve insulin sensitivity in teens aged 10-17 with prediabetes. Fifteen overweight or obese participants will use the Dexcom G7 device to see real-time glucose data, aiming to bo…

This study looks at whether adding baked potatoes (with skin) to a Mediterranean diet can improve blood sugar control, blood pressure, and cholesterol in adults aged 45-80 with pre-diabetes. Sixty participants will either get diet education alone or education plus pre-prepared ba…

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will take part in weekly physical activity, health education, and work with a coach and trainer. The goal is to see if the program improves heart health and reduces st…

This study tests whether a supplement called dihydroberberine (DHB) can improve blood sugar control, appetite, and energy in adults with prediabetes. About 54 participants will take either DHB or a placebo daily for 6 weeks. Researchers will measure blood sugar, insulin, and GLP-…

This study is testing whether wearing a smartwatch and getting personalized health coaching through a mobile app can help people with high blood pressure, diabetes, obesity, or related conditions improve their lifestyle. About 1,700 adults aged 21-75 will wear a smartwatch for at…

This study provides 400 adults with diabetes or prediabetes who struggle to afford food with free fresh food boxes and nutrition classes twice a month for six months. Researchers will check if this program helps lower blood sugar levels and reduces food insecurity. The goal is to…

This study from the University of Oxford is testing whether a finger-prick blood test, done at home, can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard OGTT requires a vein drip and mult…

This study tests a family-oriented version of the Diabetes Prevention Program for Black families in Southwest Georgia. Parents with prediabetes and their children aged 8-15 will learn healthy eating and exercise habits together. The goal is to help parents lose weight and lower t…

This study is testing whether a special software that analyzes CT scans of the heart's arteries can better prevent heart attacks, strokes, and other cardiovascular events compared to usual care based on risk factors like cholesterol and blood pressure. The trial will enroll 7,500…

This study tests whether giving adults at risk for type 2 diabetes free fresh fruits and vegetables, along with a proven lifestyle program, can help them lower blood sugar and lose weight. One hundred adults with prediabetes will either get the standard diabetes prevention progra…

This study tests whether the drug semaglutide can prevent type 2 diabetes in women who had gestational diabetes and now have high blood sugar after pregnancy. About 252 women will receive either semaglutide or a placebo for several months. The goal is to see if the drug lowers th…

This study tests whether a smartwatch-based program, combined with coaching from healthcare staff, can improve heart health in overweight or obese adults who have early signs of problems like high blood pressure or prediabetes. The program focuses on exercise and diet, and tracks…

This study tests whether teaching basic carbohydrate counting can lower blood sugar levels in people with prediabetes. About 120 adults with prediabetes will either get standard lifestyle advice or extra training on counting carbs. Researchers will check HbA1c levels at 3 and 6 m…

This study tests whether adding continuous glucose monitoring (CGM) to the standard Diabetes Prevention Program (DPP) helps adults with prediabetes stick with healthy habits and lower their risk of developing type 2 diabetes. About 214 adults with prediabetes will receive DPP coa…

This study tests whether wearing a continuous glucose monitor (CGM) and watching AI-generated health videos can help people with prediabetes control their blood sugar. Fifty adults aged 35 and older with prediabetes will wear a CGM and receive smartphone feedback. The goal is to …

This pilot study tests whether a 12-week family-centered, non-calorie restricted whole foods diet can help prevent type 2 diabetes in adults with prediabetes. About 30 adult-child pairs will participate, with adults having prediabetes and children aged 6-18. The study measures fe…

This study looks at two different ways to help adults in rural communities prevent type 2 diabetes. Participants will either join group video sessions or follow a self-directed program. The goal is to see which method works better for weight loss and blood sugar control.

This study tests an online diabetes prevention program for UCLA undergraduates who are at risk for type 2 diabetes. The program includes short online lessons and aims to help participants lose weight and improve quality of life. Researchers will compare results between those who …

This study looks at whether walking in a natural setting (like a park) is better for reducing stress, anxiety, and improving mood compared to walking in a built-up commercial area. 216 adults with prediabetes will walk 150 minutes per week for six weeks in each environment, with …

This study looks at whether short-term beetroot juice (a source of nitrate) can improve blood vessel function, insulin sensitivity, and exercise ability in adults with prediabetes. Researchers will compare people who take metformin with those who do not. The goal is to find simpl…

This study tests whether easy home-based strategies—like wearing blue-light blocking glasses, standing for 10 minutes each hour, and not eating after 8pm—can reduce the negative health effects of evening screen time. Researchers will track 30 adults with obesity or prediabetes wh…

This study tests whether a cold water extract from saffron tepals (the flower petals) can improve blood sugar and metabolism after a meal in 20 adults with obesity or prediabetes. Participants drink either the extract or plain water before eating white bread, then have blood test…

This study tests whether brief, mild low-oxygen breathing sessions can improve blood vessel function, lower blood pressure, and reduce tiredness in people with obstructive sleep apnea. Researchers will enroll 60 adults aged 30-60 who are newly diagnosed and not yet using CPAP. Th…

This study tests whether eating all meals within an early 8-hour window (and cutting calories by 25%) can improve blood sugar and heart health in people who are overweight and have prediabetes, type 2 diabetes, or normal blood sugar. Thirty participants will try either early or l…

This study is looking for biological markers (biomarkers) in blood, saliva, and urine that signal damage to insulin-producing beta cells in the pancreas. Researchers will compare samples from people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers. The g…

This study looks at whether personality traits are linked to routine lab test results in 1,000 adults getting a health check-up. Participants fill out a personality questionnaire and provide blood samples. The goal is to see if certain personality types are more likely to have ab…

This study looks at tiny particles called extracellular vesicles (EVs) released from fat cells. Researchers want to understand how these particles carry signals that may affect heart and liver health in people with obesity. About 100 adults having weight-loss surgery will provide…

This study looks at how fat buildup in the pancreas contributes to type 2 diabetes and whether weight loss can reverse it. Researchers will follow 104 overweight adults, including those without diabetes, with prediabetes, and with short- or long-term diabetes. Participants will f…

This study looks at how lean pork loin and plant-based protein affect muscle building and blood sugar control in adults with prediabetes. Twenty participants aged 40-65 will eat prepared meals for three days. Researchers will measure muscle protein synthesis and glucose levels to…

This study is testing whether a smartphone-based program that provides high-fiber foods and continuous glucose monitors can help young adults (ages 18-39) with prediabetes improve their blood sugar control. The main goal is to see if people find the program easy to use and stick …

This study looks at how certain immune cells, called meta-inflammatory monocytes, along with body composition and diet, may contribute to insulin resistance in adolescents. Researchers will collect blood samples and health information from 175 teens aged 14-18, including those wi…

This study is looking for early warning signs of diabetes and its complications. Researchers will give a high-fat drink to 150 adults (ages 50-70) with prediabetes, type 2 diabetes, or healthy blood sugar. They will measure fats and inflammation in the blood before and after the …

This study is testing whether a pharmacist-led program that uses continuous glucose monitors (CGMs) can help people with prediabetes better control their blood sugar and make healthier choices. About 40 adults with prediabetes will wear a CGM for 12 weeks and receive guidance fro…

This study looks at how a person's natural sleep pattern (chronotype) affects their body's ability to handle sugar. Researchers will compare blood sugar and insulin responses in 70 overweight young adults (ages 18-23) who are either night owls or early birds. Participants will ta…

This study looks at how the hormone glucagon affects insulin release and blood sugar levels in people with prediabetes. Researchers will give glucagon or sugar water to 60 volunteers and measure how their bodies respond. The goal is to better understand what causes high blood sug…

This study looks at whether a community program rooted in Native Hawaiian values can improve the well-being of young people aged 12-25 who have health issues like asthma, obesity, or mental health concerns. About 100 youth from the Wai'anae area will take part in cultural activit…

This study follows 1,000 people who are having weight-loss (bariatric) surgery. Researchers will measure changes in weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits over two years. The goal is to better understand…

This study looks at whether eating dinner earlier in the evening, in sync with your body's internal clock, helps burn more fat and control blood sugar. Researchers will compare early versus late dinner in 32 adults—some healthy weight, some with obesity and prediabetes. Participa…

This study looks at how a person's genetic makeup influences their response to oral semaglutide (Rybelsus), a drug used for type 2 diabetes. Researchers will give 125 adults with prediabetes a 14-day course of the drug and measure blood sugar, insulin, and other factors after a s…

This study looks at how genetic differences in Mexican-Americans with prediabetes affect their response to semaglutide (Ozempic), a GLP-1 drug. Researchers will measure changes in insulin production and sensitivity, and analyze gene activity. The goal is to understand why some pe…

This study looks at how an 8-week exercise program changes the bodies and cells of 40 overweight or obese adults with prediabetes. Researchers will measure weight, body fat, blood sugar, and other health markers. They will also use advanced techniques to study immune cells and fi…

This study is following 1,250 people at higher risk for pancreas cancer, including those with new diabetes, pancreatic cysts, or a family history. Researchers will collect blood samples and health data twice a year for several years. The goal is to find early markers in the blood…

This study tests whether data from a smart ring, smartwatch, and smartphone app can identify people with prediabetes (higher-than-normal blood sugar) compared to healthy individuals. About 200 adults aged 45 and older who are overweight will wear these devices for 4 weeks and log…

This pilot study tests whether adding hands-on nutrition demonstrations to the standard Diabetes Prevention Program (DPP) helps recruit and keep participants engaged. Twenty adults with prediabetes from two community health centers in Los Angeles will take part. The main goal is …

This study looks at how a hormone called GLP-1, made in the pancreas, helps control blood sugar in people with prediabetes. Researchers will give a drug that blocks GLP-1 to see how it changes insulin and glucagon release. The goal is to understand why some people with prediabete…

This study looks at whether the artificial sweeteners aspartame and sucralose affect blood sugar control in adults aged 40 and older with prediabetes. Participants will receive either one of the sweeteners or a placebo as part of their diet for 8 weeks. Researchers will monitor b…

This study from Stanford University is looking for 100 volunteers to help understand why people's blood sugar levels respond differently to the same foods. Participants will wear a continuous glucose monitor and test various meals, supplements, and short exercises. The goal is to…

This study will follow 2,000 adults with metabolic syndrome or prediabetes over time to understand how these conditions progress and lead to complications. Researchers will track health records, nutrition, and physical function to find key factors that affect long-term outcomes. …

This study looks at how insulin and glucagon work together to control blood sugar levels when people are not eating. Researchers will give insulin and a fat emulsion to 60 volunteers with normal or impaired fasting glucose to see how their bodies respond. The goal is to better un…