PREDIABETES

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This study tested whether giving extra support to Black adults who don't lose weight early in a diabetes prevention program helps them lose more weight. Over 400 participants joined a 12-week program at churches or community centers. Those not losing weight early got extra phone …

This study looks at whether using a continuous glucose monitor (CGM) alongside standard nutrition and activity advice can improve metabolic health in young people aged 11 and older who have prediabetes and are overweight. Participants wear the CGM intermittently to see how daily …

This study tested whether regularly removing blood (like donating blood) can lower iron levels and improve diabetes control and fatty liver disease. 132 adults aged 40-75 with prediabetes or diabetes took part. The treatment group gave blood several times, while the control group…

This study tested whether a lifestyle guide called GEM (Glycemic Excursion Minimization), combined with a continuous glucose monitor (Freestyle Libre 2) and a Fitbit activity tracker, could help people with prediabetes better manage their blood sugar. Sixty-one adults aged 25-70 …

This study looked at whether bread made from watermelon rind could improve heart health in 120 adults with mild to moderate heart issues. Participants were between 35 and 65 years old and had conditions like high blood pressure, unhealthy cholesterol levels, or pre-diabetes. The …

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This study tested whether using portable air cleaners at home can improve blood sugar control and reduce inflammation in adults with prediabetes. 150 participants used either real or sham air cleaners for 4 weeks. Researchers measured changes in blood sugar patterns and inflammat…

This study looked at whether three different low-calorie diets could improve blood sugar and body composition in 120 shift workers who are overweight and have prediabetes or type 2 diabetes. Each diet had a different amount and timing of protein. The goal was to see which approac…

This pilot study tested a mobile app and wearable devices to give personalized diet and activity advice to 27 adults with type 2 diabetes or prediabetes. The goal was to see if the app could help them improve their blood sugar levels and make healthier food choices. The study als…

This study looked at whether a low-carb, high-fat ketogenic diet with fewer calories can reduce inflammation and improve blood sugar control in prediabetic obese adults aged 18 to 40. Ninety participants were split into three groups: a keto diet, a normal diet with fewer calories…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested a special nutritional supplement containing apple extract, chromium, zinc, magnesium, and cinnamon in 21 people with prediabetes. The goal was to see if it could help control blood sugar spikes after meals. The supplement is designed to be taken long-term to man…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study looked at whether a 3-month supervised exercise program can improve blood sugar, body fat, and fitness in sedentary men aged 35-65 with type 2 diabetes, prediabetes, or overweight. Participants exercised at a fitness center under supervision. The goal was to see how di…

This study tested whether doing aerobic exercise at home with remote supervision (tele-exercise) works as well as exercising in a hospital for people with prediabetes. Forty-two adults with prediabetes walked for 30 minutes, five days a week, for three weeks. One group exercised …

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This study tested whether wearing a continuous glucose monitor (CGM) and watching AI-generated health education videos could help 30 adults with prediabetes control their blood sugar. Participants wore a CGM that tracked glucose levels without showing them the readings during the…

This study tested whether taking a prebiotic fiber called inulin every day for 6 weeks could improve how the body handles sugar and fat in prediabetic adults. Twenty-two participants ate a controlled diet and either got inulin or a placebo. Researchers measured insulin sensitivit…

This study tested whether a supplement called nicotinamide mononucleotide (NMN) can improve how the body handles sugar in people with prediabetes. Researchers gave NMN to 56 adults with higher-than-normal blood sugar and measured changes in insulin sensitivity and glucose toleran…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This study tested whether Garcinia cambogia rind powder, a dietary supplement, can improve weight, blood sugar, and cholesterol in 90 pre-diabetic obese adults aged 30-60. Participants took the powder daily for 12 weeks. The goal was to see if it helps control metabolic problems …

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This study tested a mobile platform designed for people with prediabetes. It combines educational games, lifestyle challenges, and community interaction to encourage healthy habits. Sixty participants used the platform, and researchers tracked their diet, exercise, and blood suga…

This study looked at how well the Xience Sierra drug-coated stent works in a broad group of heart disease patients, including those with diabetes or prediabetes. Over 1,700 participants received the stent during a routine procedure to open blocked arteries. Researchers tracked he…

This study tested a weekly injection of semaglutide (2.4 mg) in 207 adults with obesity and prediabetes. Participants received either the drug or a placebo for 12 months, plus lifestyle advice. The goal was to see how much weight they lost and whether their blood sugar returned t…

This early-phase study tested a special form of cannabidiol (CBD) called DehydraTECH, alone or combined with GLP-1 drugs (like Ozempic), in 148 overweight or obese adults with prediabetes or type 2 diabetes. The main goal was to check safety and how the body processes the drugs, …

This study tested whether adding green tea extract to standard metformin treatment can improve insulin resistance in obese children aged 10-18 with prediabetes. 90 participants were split into two groups: one received metformin alone, the other added green tea extract three times…

This study looked at whether a gut bacterium called Akkermansia muciniphila and a natural compound called berberine can help manage prediabetes in obese adults. 110 overweight or obese people with prediabetes were given either the bacterium, berberine, or a placebo for 12 weeks. …

This study looked at whether adding a nurse trained in diabetes care to the treatment team helps breast cancer patients with diabetes or prediabetes manage their blood sugar during cancer therapy. Researchers split 74 patients into two groups: one worked with the diabetes nurse, …

This study tested an AI system called X Life that gives personalized diet and exercise tips to people with prediabetes or type 2 diabetes. Twenty participants used the system for 7 days via AR glasses or a smartphone. The goal was to see if people found it easy and helpful, not t…

This study tested whether it's possible to use the diabetes drug empagliflozin in 60 veterans with prediabetes. Participants took the drug or received standard lifestyle advice for 12 weeks. The main goal was to see if people would join and stay in the study, not to prove the dru…

This study looked at whether adding dapagliflozin to metformin helps people with prediabetes or type 2 diabetes and severe obesity lose more weight than metformin alone. About 160 participants took either both drugs or just metformin for up to 12 months. The main goal was to see …

This pilot study tested whether a 5-day fasting-mimicking diet (FMD) is feasible and can lower blood sugar in 30 Asian Americans with prediabetes. Participants ate a special plant-based meal kit for five days, then had their blood sugar and physical measurements checked. The goal…

This study looked at whether taking fish oil and doing high-intensity interval training (HIIT) could lower inflammation in people who are overweight or obese. Researchers measured changes in blood markers of inflammation and metabolism over 10 weeks. The goal was to see if the co…

This study tested whether taking a synbiotic (a mix of probiotics and prebiotics) for 6 months could improve blood sugar control, reduce inflammation, and change body composition in adults with prediabetes or type 2 diabetes. Researchers recruited 64 participants from a hospital …

This study tested whether computer analysis of voice recordings can detect type 2 diabetes. Over 7,000 adults in the UK recorded themselves reading and answering questions online. A subset also provided blood samples to check accuracy. The goal is to see if voice biomarkers could…

This study tested a new device called the Cmate blood glucose analyzer, which measures blood sugar without needing a finger prick. Researchers compared its readings to standard blood tests in 40 healthy, pre-diabetic, and diabetic adults. The goal is to see if this non-invasive m…

This study looked at two different exercise programs in 24 adults with prediabetes (higher than normal blood sugar but not yet diabetes). One group did short bursts of intense exercise (HIIT), the other did steady moderate exercise. Researchers measured changes in blood sugar, ch…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested a 1-year online program designed to help adults aged 40-70 who are at risk for heart disease become more physically active. Participants either received a fitness tracker plus online coaching and goal-setting sessions, or just a fitness tracker with standard act…

This study looked at whether limiting when you eat (time-restricted eating) can improve blood sugar control and heart health in adults with prediabetes. 108 participants were assigned to eat only between 8am-3pm, 1pm-8pm, or a normal 12-hour eating window for 8 weeks. All meals w…

This study tested whether a habit-formation smartphone app could help adults with prediabetes stay engaged in the National Diabetes Prevention Program. Researchers compared how many classes people attended and how long they stayed in the program between those who used the app and…

This study tested whether a lifestyle modification program—including diet advice, exercise plans, and mobile reminders—could reduce the risk of prediabetes progressing to type 2 diabetes. 124 adults with prediabetes participated. The goal was to see if simple, everyday changes co…

This study tested a program to prevent type 2 diabetes in Chinese immigrants with prediabetes. Participants received weekly videos on diabetes prevention and fresh, culturally appropriate produce. The goal was to see if this approach could help people lose weight and build health…

This completed study compared two versions of the Diabetes Prevention Program in 304 overweight adults with prediabetes. One group followed the standard lower-calorie, lower-fat diet, while the other tried a very low-carbohydrate diet. Researchers measured changes in blood sugar …

This study tested whether a fully automated digital program could help people with prediabetes lose weight and lower their blood sugar as effectively as a program led by a human coach. About 368 adults with prediabetes and overweight took part. The goal was to see which approach …

This study tested whether letting people with prediabetes set their own health goals (NDPP-Flex) works better than the standard diabetes prevention program. About 200 adults from Denver Health took part. The goal was to see if this flexible approach could lower blood sugar and he…

This study tested a special diabetes prevention program for college students at high risk for type 2 diabetes, especially those facing challenges like food or financial insecurity. 80 UCLA undergraduates with prediabetes or high risk were randomly assigned to either the program o…

This study tested whether helping people with pre-diabetes get more sleep could improve their blood sugar control and lower their risk of developing type 2 diabetes. Researchers worked with 150 adults who slept less than 6.5 hours per night, giving some a personalized sleep exten…

This study tested whether a 12-week virtual exercise program called Vivo could improve leg strength and blood sugar levels in sedentary older adults with prediabetes. 74 people aged 60 and older participated, meeting twice a week online with a trainer. The goal was to see if this…

This study tested whether taking Nextida-GC (a collagen peptide) or whey protein before breakfast can lower blood sugar spikes after eating. Thirty-two healthy adults, some with prediabetes, drank the supplement 30 minutes before, 10 minutes before, or with a standard breakfast. …

This study looked at whether a collagen supplement can improve blood sugar levels after a meal in people with normal blood sugar or prediabetes. Thirty adults took either collagen or a placebo and then had their blood sugar, insulin, and digestion tracked. The goal was to see if …

This study tested a mindfulness program for 30 teens aged 12-18 with prediabetes or type 2 diabetes. The goal was to see if the program was practical and liked by teens, and to explore any effects on health measures like blood sugar. The approach involved group sessions and quest…

This study tested whether daily text messages and small financial rewards could motivate overweight teens and young adults with prediabetes or type 2 diabetes to be more physically active. 75 participants wore a Fitbit and received different combinations of texts and incentives o…

This study tested whether an online, live strength training program called Vivo is feasible and acceptable for sedentary older adults with prediabetes. Twenty-eight participants took part in 45-minute classes twice a week for 12 weeks. The study measured leg strength, attendance,…

This study tested whether a special fiber supplement changes intestinal gas production over 36 hours in 29 adults. Participants included lean healthy people and those with insulin resistance or prediabetes who were overweight. Researchers measured gas levels, energy use, and gut …

This study looked at whether exercising in the morning (7-11am) or afternoon (4-8pm) makes a difference for people with type 2 diabetes or prediabetes. Thirty-six adults did 10 supervised exercise sessions at a high intensity. Researchers measured changes in body weight, blood su…

This study looked at how short periods of low oxygen (from holding your breath) affect blood sugar levels after drinking a sugary drink. Researchers tested 20 healthy adults, people with prediabetes, and people with type 2 diabetes. The goal was to learn more about how oxygen lev…

This study looked at how the hormone glucagon affects the liver's ability to break down proteins and fats in people with obesity, type 2 diabetes, and fatty liver disease. Researchers wanted to understand if the body becomes resistant to glucagon in these conditions. A total of 2…

This study tested whether sodium phenylbutyrate can lower levels of branched chain amino acids (BCAAs) in the blood of obese and prediabetic men. High BCAAs are linked to insulin resistance and type 2 diabetes. Researchers also looked at how the drug affects blood sugar, insulin …

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This pilot study looked at whether removing oxysterols (harmful compounds in cooked animal foods) from the diet could improve insulin production in African Americans with prediabetes or early type 2 diabetes. Twelve participants ate a plant-based diet free of oxysterols for a per…

This study looked at whether two common artificial sweeteners—saccharin and acesulfame-potassium—affect blood sugar levels in middle-aged and older adults with prediabetes. Fourteen participants ate controlled breakfasts with or without these sweeteners, and their blood glucose w…

This study looked at whether artificial sweeteners like Equal (aspartame) and Splenda (sucralose) raise blood sugar in adults with prediabetes. Fourteen participants ate controlled breakfasts with or without sweeteners, and their glucose levels were tracked for two hours. The goa…

This study looked at whether showing people their real-time blood sugar levels (using a continuous glucose monitor) changes how much they value a milk drink made with mulberry leaf extract. About 170 non-diabetic Chinese adults aged 45-75 took part. The goal was to see if seeing …

This small study looked at whether sourdough bread made with a longer fermentation time (which increases natural acids) could lower blood sugar spikes in adults with prediabetes. Five participants ate different sourdough breads and had their blood sugar measured afterward. The go…

This study looked at 2188 adults with type 2 diabetes or prediabetes to see if three simple blood test scores could predict heart and metabolic risk. The researchers calculated the triglyceride-glucose index, atherogenic plasma index, and systemic immune-inflammation index from r…

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition …

This completed study looked at 94 older adults to compare how prediabetes and type 2 diabetes affect cognitive status, physical function, and fatigue. Participants were grouped by their HbA1c levels (healthy, prediabetic, or diabetic) and tested with tools like the Montreal Cogni…