Weekly shot helps people with obesity and prediabetes shed pounds and fix blood sugar

NCT ID NCT05040971

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a weekly injection of semaglutide (2.4 mg) in 207 adults with obesity and prediabetes. Participants received either the drug or a placebo for 12 months, plus lifestyle advice. The goal was to see how much weight they lost and whether their blood sugar returned to normal. The study is complete, and results showed significant weight loss and improved blood sugar levels compared to placebo.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

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Locations

Aarhus Universitetshospital Diabetes og Hormonsygdomme

Aarhus N, 8200, Denmark
C-endo Diab Endo Clin Calgery

Calgary, Alberta, T2V 4J2, Canada
CHU de Quebec-Universite Laval

Québec, G1V 4G2, Canada
Centre Medical Acadie

Montreal, Quebec, H4N 2W2, Canada
Centre de recherché du CHUS

Sherbrooke, Quebec, J1H 5N4, Canada
Centricity Research LMC

Toronto, Ontario, M4G 3E8, Canada
Claremont Medical Practice

Exmouth, EX8 2JF, United Kingdom
Clifton Medical Centre

Rotherham, South Yorkshire, S65 1DA, United Kingdom
Clinique Medicine Urbaine du Quartier Latin, Inc.

Montreal, Quebec, QC H2L 4E9, Canada
Ctr de Med Metab de Lanaudiere

Terrebonne, Quebec, J6X 4P7, Canada
Diabetes Heart Research Centre

Toronto, Ontario, M6G 1M2, Canada
Dr Anil K Gupta Med Prof Corp

Toronto, Ontario, M9V 4B4, Canada
G.A. Research Associates Ltd.

Moncton, New Brunswick, E1G 1A7, Canada
GP Direct

Harrow, HA2 0RQ, United Kingdom
Guys Hospital

London, SE1 9RT, United Kingdom
Hospital Clinico San Carlos

Madrid, 28040, Spain
Hospital Gregorio Marañón

Madrid, 28009, Spain
Hospital Infanta Luisa

Seville, 41010, Spain
Hvidovre Hospital Endokrinologisk forsknings afsnit 159

Hvidovre, 2650, Denmark
Institut universitaire de cardiologie

Québec, G1V 4G5, Canada
LMC Clin Res Inc. Calgary

Calgary, Alberta, T2H 2G4, Canada
LMC Clin Res Inc. Thornhill

Concord, Ontario, L4K 4M2, Canada
LMC Clin Rsrch Inc. (Montreal)

Saint-Laurent, Quebec, H4T 1Z9, Canada
LMC ClinRsrh Inc.Brampton

Brampton, Ontario, L6S 0C6, Canada
LMC Clinical Research Inc. Oakville

Oakville, Ontario, L6M 1M1, Canada
LMC Diabetes & Endocrinology (Barrie)

Barrie, Ontario, L4N 7L3, Canada
LMC Endo Ctr (Etobicoke) Ltd

Etobicoke, Ontario, M9R 4E1, Canada
LMC Research Inc. Ottawa

Nepean, Ontario, K2J 0V2, Canada
Manna Research Mirabel

Mirabel, Quebec, J7J 2K8, Canada
Milestone Research

London, Ontario, N5W 6A2, Canada
MyHealth - Strensall Health Care Centre

Strensall, YO32 5UA, United Kingdom
Nova Scotia Hlth Halifax

Halifax, Nova Scotia, B3H 2Y9, Canada
Obesity Research Unit

Helsinki, 00014, Finland
Ocean West Research Clinic

Surrey, British Columbia, V3Z 2N6, Canada
Premier Clinical Trial Research Network (PCTRN)

Hamilton, Ontario, L8M 1K7, Canada
StudyCor

Jyväskylä, 40620, Finland
The Health Centre

Bradford-on-Avon, BA15 1DQ, United Kingdom
The Staploe Medical Centre

Soham, CB7 5JD, United Kingdom
Toronto Sleep Institute/MedSleep

Toronto, Ontario, M4P 1P2, Canada
University Hospital Coventry - WISDEM Centre

Coventry, CV2 2DX, United Kingdom
University of Calgary

Calgary, Alberta, T2T 5C7, Canada
Weight Wise Clinic

Edmonton, Alberta, T6G 2R3, Canada
Wharton Med Clin Trials

Hamilton, Ontario, L8L 5G8, Canada

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