Can a new injection help tackle obesity? a trial puts it to the test
NCT ID NCT07808073
First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time
Summary
This early-stage trial tests an experimental drug called LY4329090 in adults with obesity or overweight. The main goal is to see how safe and tolerable the drug is, and how the body processes it. Participants receive either the drug or a placebo by injection, and researchers monitor side effects and measure changes in body weight. The study involves two parts with different dosing schedules and lengths of participation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- LY4329090, an experimental drug given by injection
- What this could lead to
- If successful, this could lead to a new medication for weight management in people with obesity or overweight.
- What could go wrong
- This is an early Phase 1 trial, so the main goal is safety and tolerability, not proof of weight loss. The drug may cause side effects or may not work as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 184 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Participant must be 18 (21 for Singapore site) to 65 years of age, inclusive, at the time of signing the informed consent. * Are overtly healthy with no comorbidities related to body mass index (BMI). * Have a BMI between 27.0 kilograms per square meter (kg/m²) and 40.0 kg/m², inclusive. * Have had a self-reported stable weight for 3 months prior to screening. Exclusion Criteria: * Have a history or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal (GI), endocrine, hematological, or neurological disorders. * Have a history of chronic medical conditions involving the heart, liver, or kidneys. * Have either * ongoing asymptomatic bradycardia defined as less than 50 beats per minute at screening visit * electrocardiogram (ECG) findings at screening visit of second-degree atrioventricular block or higher, or * history of symptomatic bradycardia with uncorrected etiology, including diagnosis of sick sinus syndrome. * Have an abnormal blood pressure and/or pulse rate at screening. * Have an obesity induced by other endocrinologic disorders or diagnosed monogenetic or syndromic forms of obesity. * Have any of the following: * a diagnosis of hypocalcemia or hypercalcemia, or * confirmed abnormal laboratory values for calcium and serum phosphorus. * Have a known, clinically significant gastric emptying abnormality, have undergone weight loss surgery, or have had endoscopic and/or device-based therapy for obesity or have had device removal within the last 6 months. * Have been diagnosed with type 1 or type 2 diabetes mellitus or have glycated hemoglobin A1c (HbA1c) greater than or equal to (≥) 6.5 percent (%) or 48 millimoles per mole (mmol/mol) at screening. * Have a history or presence of psychiatric disorders, within the last 2 years, that would present a safety risk or may significantly impair the participant's ability to comply with study procedures. * Have taken any glucose-lowering medications, including insulin, in the past 3 months before screening. * Have received any drugs from the incretins class within 90 days prior to screening. * Have been treated within 3 months prior to screening or plan to be treated with prescription medications that promote weight loss. * Intend to use any weight loss medications during study participation. * Prior (within 6 months) or planned (during the study) device-based treatment use for obesity.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
3 sites in 2 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Fortrea Clinical Research Unit
Daytona Beach, Florida, 32117, United States
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Fortrea Clinical Research Unit
Dallas, Texas, 75247, United States
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Lilly Centre for Clinical Pharmacology
Singapore, 138623, Singapore
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