PREDIABETES

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals plus c…

This study tests a special drink with carob extract (NUTIFOOD) to see if it helps people with prediabetes manage their blood sugar. About 30 adults with prediabetes will drink either the carob product or a placebo for a period, and researchers will measure changes in blood sugar …

This study tests whether using a continuous glucose monitor (CGM) helps overweight teens with prediabetes follow lifestyle changes better than lifestyle changes alone. The goal is to improve insulin sensitivity and lower the risk of developing type 2 diabetes. About 15 teens aged…

This study looks at whether eating only during certain hours (early or late in the day) can help control blood sugar and improve heart health in people who are overweight and have normal blood sugar, prediabetes, or type 2 diabetes. Researchers will track 30 participants' glucose…

This study tests whether personalized oral hygiene advice from artificial intelligence (AI) can improve gum health and blood sugar levels in people with prediabetes, compared to advice from a dentist. About 148 adults with prediabetes and gum disease will receive either AI-based …

This small pilot study is testing whether eating bottarga (a type of fish roe) every day for 8 weeks can improve cholesterol, blood sugar, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 adults from Massachusetts will take part. The goal is to see if t…

This study compares two diabetes medications, semaglutide and dapagliflozin, against standard treatment (metformin) to see if they can slow or reverse the buildup of plaque in the heart arteries. The trial involves 300 adults with pre-diabetes and confirmed coronary artery diseas…

This study looks at whether eating peanuts every day can improve blood sugar, blood pressure, thinking skills, and gut health in adults with prediabetes. Researchers will enroll 72 racially diverse adults aged 20-59 who have prediabetes but no peanut allergies. Participants will …

This study tests whether a supplement called dihydroberberine (DHB) can help adults with prediabetes improve blood sugar control, appetite, and energy. Over 6 weeks, 54 participants will take either DHB or a placebo daily. Researchers will measure blood sugar, insulin, and GLP-1 …

This study looks at whether a 4-week intermittent fasting plan can improve how well the pancreas releases insulin in people with prediabetes or early type 2 diabetes. Researchers will compare fasting to a regular diet in 200 adults with a BMI between 25 and 40. The goal is to fin…

This study tests whether adding SMS reminders with diet and exercise tips to a standard lifestyle program helps people with prediabetes lose more weight. About 300 adults in Reunion Island will be split into two groups: one gets the program plus 72 text messages over 6 months, th…

This study tests if a mobile app called PortionSize Ed can help 40 adults who recently had a stroke and have prediabetes or type 2 diabetes follow a Mediterranean diet. Participants will either use the full app with dietitian support or a basic version. The goal is to see if the …

This study tests a supplement called Nextida GC-B to see if it helps control blood sugar after meals in adults with normal blood sugar or prediabetes. Sixty participants will take either the supplement or a placebo daily for 90 days. Researchers will measure changes in blood suga…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a bilingual program that combines peer support and mobile health tools to help reduce these health risks. About 200 adults from a North Carolina HIV clinic will ta…

This study tests an investigational drug called MOTS-c in 120 adults with prediabetes and overweight or obesity. Participants receive either MOTS-c or a placebo for 12 weeks, along with lifestyle advice. The main goal is to see if MOTS-c improves how the body uses insulin, which …

This study is testing whether giving free fresh food boxes and nutrition education to 400 adults with diabetes or prediabetes can improve their diet, reduce food insecurity, and help control blood sugar levels. Participants receive food boxes twice a month for six months. The goa…

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will do weekly physical activity and health education, and work with a coach and community health worker. The goal is to see if the program improves heart health and r…

This study tests whether a keto diet using canola oil (healthy fats) is better for heart health than a traditional keto diet high in saturated fat or a low-fat diet. Researchers will measure cholesterol, blood sugar, and inflammation in 175 adults with prediabetes or type 2 diabe…

This study tests whether a mobile health program that provides high-fiber foods, education, and continuous glucose monitors can help young adults (ages 18-39) with prediabetes improve their blood sugar control. The study will enroll 80 participants in the Tulsa area and measure h…

This study looks at whether a pharmacist-led program using continuous glucose monitors (CGMs) can help people with prediabetes better control their blood sugar and adopt healthier habits. About 40 adults aged 18-70 with prediabetes will wear a CGM for 4 weeks and receive pharmaci…

This study looks at whether eating baked potatoes (with the skin) as part of a Mediterranean diet can improve blood sugar, cholesterol, and heart health in adults with pre-diabetes. Sixty people aged 45-80 will either follow the Mediterranean diet alone or add baked potatoes for …

This study tests whether meal replacements can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and improve blood sugar control. About 20 participants will follow an intensive nutrition program for several weeks. The goal is to see if this approach…

This study tests whether connecting youth (ages 12-25) to community programs rooted in Native Hawaiian culture can improve their mental and chronic health. Participants will take part in cultural activities and complete surveys about their well-being. The goal is to see if this a…

This study looks at whether using portable air cleaners at home can improve blood sugar control and reduce inflammation in adults with prediabetes. Researchers will measure changes in glucose levels and inflammatory markers over 4 weeks. The goal is to see if reducing air polluti…

This study tests whether simple home-based strategies and wearable devices can reduce the negative health effects of evening screen time. Researchers will enroll 30 adults who are overweight, inactive, and spend at least 3 hours of recreational screen time after 5pm. Participants…

This study is testing if a medication called Mirabegron, currently used for overactive bladder, can help people with prediabetes. Researchers want to see if the drug can activate special 'beige' fat in the body to improve how it processes sugar and insulin. About 65 adults with p…

This study compares two approaches to prevent type 2 diabetes in 40 adults with prediabetes. One group follows the standard Diabetes Prevention Program, while the other adds sleep health advice and time-restricted eating. The goal is to see which method leads to more weight loss …

This pilot study tests whether a 12-week family-centered, non-calorie restricted whole foods diet can help prevent type 2 diabetes in adults with prediabetes. About 30 adult-child pairs will participate, with adults having prediabetes and children aged 6-18. The study measures ho…

This study tests whether using a smartwatch and a digital health coach can help people at risk for chronic diseases like high blood pressure, diabetes, and obesity become more active. Researchers will enroll 1,700 adults aged 21-75 who have risk factors or early signs of these co…

This study tests whether using a detailed heart scan (Cleerly CAD Staging) to guide treatment can prevent heart attacks, strokes, and other heart-related events better than the usual approach of managing risk factors like cholesterol and blood pressure. The trial will include 7,5…

This study tests a tailored online program to help 80 UCLA undergraduates at risk for type 2 diabetes lose weight and improve health. Participants will take short weekly lessons over 9 months, with some receiving the full program and others getting general wellness materials. The…

This study tests whether adding continuous glucose monitoring (CGM) to the standard Diabetes Prevention Program (DPP) helps adults with prediabetes stick to healthy habits and lower their risk of developing type 2 diabetes. About 214 adults with prediabetes will use a CGM device …

This study looks at whether adding hands-on cooking and nutrition lessons can help people at risk for prediabetes stick with a diabetes prevention program. About 20 adults in Los Angeles will take part. The goal is to see if this approach is practical and helpful for keeping part…

This study tests two ways to deliver the National Diabetes Prevention Program to adults in rural areas who are at risk for diabetes. One group joins video sessions, while the other follows a self-directed plan. Researchers will track weight and blood sugar changes over 12 months …

This study tests whether wearing a continuous glucose monitor (CGM) and watching AI-made health videos on a smartphone can help people with prediabetes control their blood sugar. The goal is to prevent the condition from turning into type 2 diabetes. About 50 adults aged 35 and o…

This study tests a program called Regulation of Cues (ROC) adapted for Latinas who have prediabetes and obesity. The goal is to see if it helps them lose weight and prevent type 2 diabetes. Thirty women aged 18-55 will attend 14 sessions and rate how helpful the program is.

This study tests whether using a smart wearable device along with lifestyle coaching can improve heart health in 1,400 overweight or obese adults who have early signs of heart problems like high blood pressure or prediabetes. Participants will be tracked for 6 to 12 months to see…

This study tests whether a cold water extract from saffron flower tepals, taken just before a meal, can improve blood sugar and metabolism in 20 adults with obesity or prediabetes. Participants will drink either the extract or plain water before eating white bread, and researcher…

This study tests whether restricting food intake to a 9-hour window each day, without changing what or how much you eat, can improve heart and metabolic health. Researchers will study 100 adults with obesity and prediabetes over 12 weeks. The goal is to see if this eating pattern…

This study is following 1,000 people who are having weight-loss (bariatric) surgery to see how their bodies change over two years. Researchers will measure weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits. The goa…

This study looks at how genes influence the body's response to a hormone called GLP-1 in Mexican-Americans with prediabetes. Researchers will analyze DNA and gene activity in 300 adults to find why some people respond better to GLP-1-based treatments. The goal is to uncover new i…

This study from Stanford University aims to understand why people have different blood sugar responses to the same foods. Researchers will use continuous glucose monitors (CGMs) to track how 100 adults (with prediabetes, type 2 diabetes, or healthy) react to specific meals. The g…

This study looks at how insulin and glucagon interact to control blood sugar levels when you haven't eaten. Researchers will compare people with normal fasting glucose and those with impaired fasting glucose (a sign of prediabetes). The goal is to better understand what goes wron…

This study follows 1250 people at higher risk for pancreas cancer—such as those with new diabetes, pancreas cysts, or a family history—to find early warning signs in the blood. Participants visit Omaha twice a year to give blood samples. The goal is to develop a screening test th…

This study looks at whether eating dinner earlier in the day can improve how the body burns fat and handles blood sugar. Researchers will compare early versus late dinner in 32 adults, including healthy-weight individuals and those with obesity and prediabetes. The goal is to und…

This study looks at whether walking in nature (parks, preserves) or walking in built-up areas (shopping centers, streets) is better for reducing stress and anxiety in adults with prediabetes. About 216 people aged 25-64 will walk 150 minutes each week for six weeks in each type o…

This study looks at how the hormone glucagon changes insulin release and blood sugar levels in people with prediabetes. Researchers will give glucagon or sugar water to 60 volunteers and measure how their bodies respond. The goal is to better understand what causes high fasting b…

This study looks at how a hormone called GLP-1, made in the pancreas, helps control blood sugar in people with prediabetes. Researchers will block the hormone's action to see how it affects insulin and glucagon release. The goal is to learn why some people develop type 2 diabetes…

This study looks at how an 8-week exercise program affects metabolism in 40 overweight or obese adults with prediabetes. Researchers will measure changes in body fat, blood sugar, and other health markers, and use advanced cell analysis to understand the molecular changes. The go…