PREDIABETES

This small pilot study is testing whether eating Greek bottarga, a type of fish roe, can improve markers of metabolic health like cholesterol and blood sugar. It will involve 20 adults in Massachusetts who have conditions like prediabetes, high cholesterol, or obesity. Participan…

This study is comparing three diets to see which is best for managing heart disease and diabetes risk. It will test a keto diet using canola oil, a traditional high-saturated-fat keto diet, and a standard low-fat diet. About 175 adults who are overweight and at high risk for type…

This study is testing if a daily supplement called Dihydroberberine (DHB) can help people with prediabetes. For 6 weeks, 54 adults will take either DHB or a placebo pill. Researchers will check if it improves blood sugar control, reduces appetite, and boosts mood and energy level…

This study is testing whether time-restricted eating—limiting all daily food intake to a 9-hour window—can improve heart and metabolic health in people with obesity and prediabetes. It will involve 100 participants who will follow this eating pattern for 12 weeks without trying t…

This study is testing whether personalized oral hygiene advice from an artificial intelligence (AI) system can help people with prediabetes manage their gum health and blood sugar levels as well as advice from a human dentist. Researchers will compare the two methods over nine mo…

This study aims to find out if newer diabetes medications (semaglutide or dapagliflozin) are better than the standard drug metformin at slowing or reversing the buildup of fatty plaque in the heart's arteries of people who have both coronary artery disease and pre-diabetes. It wi…

This study is testing if simple, at-home strategies can reduce the health risks linked to too much evening screen time. Researchers are recruiting 30 adults at risk for heart disease and diabetes to try strategies like avoiding food after 8 PM, blocking blue light, and breaking u…

This study is testing if a supplement called Nextida-GC, made from collagen, can help control blood sugar spikes after a meal better than a common protein supplement (whey). Researchers are enrolling 32 healthy adults, some with prediabetes, to see if taking these supplements 30 …

This study is testing whether a structured meal replacement program can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and lower their blood sugar. Researchers will provide participants with a low-calorie nutrition plan and track their weight, bl…

This study is testing if a phone-based program can help young adults with prediabetes. The program teaches about high-fiber foods, delivers them to participants' homes, and uses a continuous glucose monitor to show how food affects blood sugar. Researchers want to see if this app…

This study is testing if restricting meals to an 8-hour window, either early or late in the day, can improve blood sugar control and heart health in people who are overweight and have prediabetes or type 2 diabetes. It will involve 30 participants who will try both eating schedul…

This study is testing if a drug called mirabegron, currently used for overactive bladder, can help people with prediabetes. Researchers want to see if the drug can activate special 'beige' fat in the body to improve how it handles sugar and insulin. The trial will enroll 65 adult…

This study is testing if adding baked potatoes with the skin to a Mediterranean-style diet education can help improve blood sugar control and heart health in adults with prediabetes. Researchers will compare the diet with potatoes to the diet education alone over 12 weeks. They a…

This study aims to understand how not having reliable access to enough food affects the health of people living with HIV, especially their risk for diabetes and heart problems. It will test a support program that uses trained peer guides and mobile phone tools to help participant…

This study is testing whether using portable air cleaners in the home can help people with prediabetes. Researchers want to see if cleaner indoor air leads to better blood sugar control and lower inflammation. The study will involve 160 adults who will use either real or sham air…

This study is testing whether providing free boxes of fresh fruits and vegetables, along with nutrition education, can help people with diabetes or prediabetes better manage their condition. The 6-month program serves 400 participants in the Bronx who struggle with food insecurit…

This study is testing a 24-week community program called Black Impact, designed to improve heart health and reduce stress in Black men. Participants will receive weekly physical activity, health education, and support from coaches. The goal is to see if this program can be a scal…

This study is testing whether a supplement called Nextida GC-B can help control blood sugar levels after meals. It will involve 60 adults who have either normal blood sugar or slightly elevated levels (prediabetes). Participants will take either the supplement or a placebo daily …

This study is testing if a program that delivers healthy, doctor-approved meals and provides lifestyle coaching is better than just receiving meals alone. It aims to help adults with HIV who also have type 2 diabetes or are at high risk for it, and who struggle to afford enough h…

This study is testing whether a mobile app can help people who have recently had a stroke and also have prediabetes or type 2 diabetes eat a healthier diet. The goal is to see if using the app to follow a Mediterranean-style diet can lower the risk of having another stroke and im…

This study is testing a special online program designed to help college students at risk for type 2 diabetes. It aims to see if a tailored, digital version of a proven diabetes prevention program can help students lose weight and improve their health. The program focuses on reach…

This study is testing a personalized approach to help people with prediabetes and disabilities lose weight to prevent type 2 diabetes. It starts participants on either a high or low-carb diet, then adjusts their plan after 4 weeks if they aren't losing enough weight. The goal is …

This large study is testing a new way to prevent heart attacks and strokes in people at risk. It compares two approaches: the standard method based on risk factors like age and diabetes versus a personalized method that uses a special heart scan to see actual artery plaque. The g…

This study is testing a behavioral program designed to help Latinas with obesity and prediabetes. The program teaches strategies to manage food cravings and urges. Researchers want to see if it helps participants lose weight and prevent the development of Type 2 diabetes.

This study aims to find the best way to deliver a proven diabetes prevention program to adults with prediabetes in rural Kansas. It will compare a group video class with a self-guided program, and test different ways to recruit participants. The goal is to help people lose weight…

This study is testing if adding text message (SMS) reminders to a standard diet and exercise program helps people with prediabetes lose more weight. 300 participants in La Réunion will follow the same health program, but half will also receive 72 encouraging texts about nutrition…

This study is testing if an enhanced version of a proven diabetes prevention program works better than the standard version. It will enroll 40 adults with prediabetes who are already in the standard program. The enhanced program adds guidance on improving sleep and restricting ea…

This study is testing if wearing a continuous glucose monitor (CGM) helps overweight children and teens with prediabetes stick to diet and exercise plans. The CGM gives real-time blood sugar readings, which researchers hope will motivate kids to make healthier choices. The goal i…

This study is testing whether a digital health coaching program using smartwatch data can help people improve their lifestyle and prevent chronic diseases. It will enroll 1,700 adults in Singapore who are at risk for or already have conditions like high blood pressure, prediabete…

This study is testing whether walking in nature areas is better for stress and health than walking in built-up urban areas for adults with prediabetes. Participants will walk 150 minutes per week for six weeks in each type of environment, with a break in between. Researchers will…

This study is testing a 12-week family diet program to see if it can help prevent type 2 diabetes. It involves adults with prediabetes and their children eating more whole foods like fruits, vegetables, and whole grains together. Researchers want to see if this approach is practi…

This small pilot study is testing whether adding hands-on cooking classes makes a standard diabetes prevention program more appealing and easier for people to stick with. Researchers will work with 20 adults at risk for diabetes at two Los Angeles community health centers. The go…

This study aims to find early warning signs of pancreatic cancer by tracking people at higher risk. Researchers will collect health information and blood samples from 1250 participants over time. The goal is to spot patterns that could lead to earlier detection and better surviva…

This early study is testing whether a water extract made from saffron flower petals can help improve blood sugar and metabolism right after a meal. Twenty adults with obesity or prediabetes will drink either the saffron extract or plain water before eating bread, and researchers …

This study aims to understand why people respond differently to a natural hormone (GLP-1) that helps control blood sugar and weight. Researchers will study 300 Mexican-American adults with prediabetes to see how their genes affect their body's response to this hormone. The goal i…

This study aims to understand how a natural hormone called GLP-1, produced in the pancreas, affects blood sugar control in people with prediabetes. Researchers will temporarily block this hormone's action in 60 participants to measure its role in regulating insulin and glucagon. …

This study aims to understand how the hormones insulin and glucagon work together to control fasting blood sugar levels in people with prediabetes. Researchers will measure how the body's sugar production responds to insulin and analyze hormone patterns in 60 participants. The go…

This study aims to understand why people have different blood sugar responses to the same foods. Researchers will use continuous glucose monitors to track how 100 participants with varying health statuses react to meals like rice, testing if adding things like fiber or vinegar he…

This study aims to understand the biological reasons why exercise helps people with prediabetes. Researchers will enroll 40 overweight or obese participants with prediabetes in an 8-week exercise program. They will measure changes in weight, body fat, and blood markers, and analy…

The objective of this project is to develop a behavioral intervention that combines wearable continuous glucose monitoring (CGM) with smartphone feedback and educational video clips generated by artificial intelligence (AI) software to improve glycemic control among individuals w…

Randomized, controlled, double-blind clinical trial with two parallel arms based on the product consumed (experimental product and placebo product) and conducted at a single center, to measure the efficacy of the liquid NUTIFOOD product (nutritional product with carob extract) on…