PREDIABETES

This study will give 100 adults with prediabetes a continuous glucose monitor (CGM) called Stelo, which tracks blood sugar every few minutes. The goal is to see if seeing real-time sugar levels helps people make better food and activity choices, lowering their A1c and improving h…

This pilot study will test whether supplements made from bilberries and olives can reduce inflammation and oxidative stress in people with prediabetes who are overweight. Researchers will collect blood, urine, and stool samples from 60 participants to measure changes in key healt…

This study tests whether a once-weekly injectable drug called mazdutide can help adults with prediabetes achieve normal blood sugar levels. About 150 participants will receive either a low dose, a higher dose, or a placebo for 24 weeks, along with diet and exercise advice. The ma…

This study tests whether a daily prebiotic drink (containing inulin) can improve blood sugar control in 30 postmenopausal women with prediabetes. Participants will consume the drink or a placebo for 4 weeks. The goal is to see if this simple dietary supplement can help reduce the…

This study tests whether a medication called chiglitazar sodium, combined with healthy lifestyle changes, can help people with prediabetes return to normal blood sugar levels. About 472 adults with prediabetes will take either the drug or a placebo for 52 weeks, along with lifest…

This study looks at whether eating one medium potato daily as part of a healthy Mediterranean diet affects blood sugar and heart disease risk in adults with prediabetes. About 74 people aged 25-65 with prediabetes will follow either a potato-inclusive or potato-free Mediterranean…

This study tests whether glucose-lowering medications (semaglutide and possibly dapagliflozin) can reverse prediabetes and prevent complications like eye, kidney, and nerve damage in people with heart disease. About 158 participants with prediabetes and coronary artery disease wi…

This study tests whether a daily probiotic called LP-LDL® can improve cholesterol, blood sugar, inflammation, and memory in 210 adults with prediabetes, type 1, or type 2 diabetes who also have high cholesterol or triglycerides. Participants take either the probiotic or a placebo…

This study tests whether replacing regular cooking oil with diacylglycerol (DAG) oil for four weeks can improve blood sugar, cholesterol, and body composition in 40 middle-aged and older adults with prediabetes. Participants will either use DAG oil or colza oil, while keeping all…

This small pilot study tests whether bromocriptine, a drug used for Parkinson's, can safely improve blood sugar problems in people with schizophrenia who have prediabetes from antipsychotic medications. Fifteen adults will take bromocriptine for 6 weeks, with researchers monitori…

This study will use ultra-high-frequency ultrasound to measure the thickness of artery layers in 1,740 adults with prediabetes. The goal is to detect early signs of blood vessel damage that could lead to heart disease. Researchers also aim to establish normal values for healthy a…

This study tests whether a digital health program with personalized support helps adults at risk for type 2 diabetes build healthy habits faster than standard lifestyle education. 222 participants will be followed for 24 weeks. The main goal is to see how quickly they can achieve…

This pilot study tests whether a single, personalized conversation with a healthcare team member or a brief message through a patient portal can encourage adults with prediabetes to take action—like joining a diabetes prevention program or starting medication. Researchers will co…

This study tests whether an enhanced diabetes prevention program that provides healthy food deliveries, exercise classes, and community resources helps African American adults with prediabetes lose more weight than a standard program. About 408 participants from low-income commun…

This study tests whether wearing a continuous glucose monitor (CGM) can motivate people with prediabetes to be more physically active. Fifty adults with prediabetes will wear a CGM for 20 days and receive education on their blood sugar readings. The goal is to see if seeing real-…

This study tests whether taking weekly vitamin D supplements, with doses adjusted to reach a target blood level, can help control blood sugar in 100 adults aged 30-74 who have prediabetes (high risk for type 2 diabetes). Participants are randomly assigned to receive vitamin D or …

This study tests whether an enhanced version of the Intensive Diabetes Prevention Program (IDPP) works better than the standard program at recruiting and keeping participants in district health centres. Researchers will compare the two approaches in 170 adults with prediabetes, l…

This study tests whether a virtual health community can help people with prediabetes improve blood sugar control and prevent type 2 diabetes. Participants will receive lifestyle support through a digital platform, including education, guidance, and group interaction. The trial wi…

This study tests whether light physical activity after meals can improve blood sugar levels in adults with metabolic syndrome and prediabetes. Twenty-five participants will try three routines in random order: sitting, a 15-minute walk, or brief resistance exercises like squats ev…

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

The EXPAND study is a research project that will enroll 440 adults with and without pancreatic conditions to understand why type 2 diabetes varies so much from person to person. Researchers will collect data on metabolism, genetics, and pancreas health to identify distinct diabet…

This study looks at how muscle cells send tiny packages called extracellular vesicles to fat cells during exercise, which may affect how the body processes sugar and fat. Researchers will compare 40 adults—some with prediabetes and some healthy—to understand why some people's fat…

This study tests whether special amino acid-enriched drinks can help people on GLP-1 weight-loss drugs maintain muscle and prevent weight regain. Eight adults aged 30-65 who recently started GLP-1 medication will drink different supplement beverages, and researchers will measure …

This study looks at whether adding a machine-learning risk label to electronic health record messages helps adults aged 65 and older better understand their risk of developing diabetes. About 1,200 participants with prediabetes will receive either standard lab results or results …

This study looks at whether eating 1.5 cups of fresh mango every day for 12 weeks can improve gut health in people with prediabetes. Researchers will measure markers of gut permeability and short-chain fatty acids in blood samples from 31 participants. The goal is to see if mango…

This study will enroll 1,000 adults at high risk for prediabetes to see if continuous glucose monitors (CGMs) combined with artificial intelligence can detect the condition earlier and more accurately than current tests. Participants will wear a CGM and provide other health data.…

This study tests a wrist-worn device that uses light sensors and AI to estimate blood sugar without piercing the skin. Up to 100 adults with type 1 diabetes, type 2 diabetes, or prediabetes will wear the device for 15 days while researchers collect data to improve its accuracy. P…

This study looks at whether exercising in the morning or evening helps the body handle sugar better in people with prediabetes who have an extreme natural body clock. Twenty-eight adults with prediabetes and overweight will do a single cycling session at 9 AM, 5 PM, or no exercis…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks at how artificial sweeteners (saccharin, sucralose) and a natural one (erythritol) affect blood sugar control, blood clotting, and heart disease risk in 80 adults with prediabetes. Participants will be randomly assigned to take one sweetener or water for two week…

This study will enroll about 225 adults aged 18-70 who are at risk for or may have early blood sugar problems, but not yet diagnosed with diabetes. Participants will wear a continuous glucose monitor for 10-14 days and take two at-home meal tests, followed by a standard glucose d…

This study will observe 120 young adults with prediabetes to understand how different types of prediabetes relate to metabolic syndrome, a cluster of conditions that raise the risk for heart disease and diabetes. Researchers will classify participants based on blood sugar levels …