New weekly shot aims to turn back the clock on prediabetes
NCT ID NCT07654062
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a once-weekly injectable drug called mazdutide can help adults with prediabetes achieve normal blood sugar levels. About 150 participants will receive either a low dose, a higher dose, or a placebo for 24 weeks, along with diet and exercise advice. The main goal is to see how many people return to healthy blood sugar after treatment, with a 24-week follow-up to check if the effects last.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mazdutide (a once-weekly injectable drug that activates GLP-1 and glucagon receptors to lower blood sugar and weight)
What this could lead to
If successful, mazdutide could offer a new option to help people with prediabetes return to normal blood sugar levels and potentially prevent or delay type 2 diabetes.
What could go wrong
This is a relatively small, early-phase trial (Phase 4) with only 150 participants, so results may not apply to everyone. The drug may cause side effects like nausea or injection-site reactions, and benefits may not last after treatment stops.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Shandong Provincial Hospital Affiliated to Shandong First Medical University
Jinan, Shandong, 250021, China
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••