New weekly shot aims to turn back the clock on prediabetes
NCT ID NCT07654062
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a once-weekly injectable drug called mazdutide can help adults with prediabetes achieve normal blood sugar levels. About 150 participants will receive either a low dose, a higher dose, or a placebo for 24 weeks, along with diet and exercise advice. The main goal is to see how many people return to healthy blood sugar after treatment, with a 24-week follow-up to check if the effects last.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mazdutide (a once-weekly injectable drug that activates GLP-1 and glucagon receptors to lower blood sugar and weight)
- What this could lead to
- If successful, mazdutide could offer a new option to help people with prediabetes return to normal blood sugar levels and potentially prevent or delay type 2 diabetes.
- What could go wrong
- This is a relatively small, early-phase trial (Phase 4) with only 150 participants, so results may not apply to everyone. The drug may cause side effects like nausea or injection-site reactions, and benefits may not last after treatment stops.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Jinan, Shandong, 250021, China
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Other studies related to the condition(s) this trial covers.
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