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Morning or afternoon? study tests best exercise time for diabetes

NCT ID NCT05108987

Knowledge-focused Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether exercising in the morning (7-11am) or afternoon (4-8pm) makes a difference for people with type 2 diabetes or prediabetes. Thirty-six adults did 10 supervised exercise sessions at a high intensity. Researchers measured changes in body weight, blood sugar control, and blood vessel health. The goal is to find if afternoon exercise offers extra benefits for metabolic health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise (morning or afternoon sessions)
What this could lead to
If it works, this could show that exercising at a specific time of day (like afternoon) is better for blood sugar and blood pressure control in people with type 2 diabetes or prediabetes.
What could go wrong
This is a small, completed study with only 36 participants, so results may not apply to everyone. The findings are preliminary and need larger studies to confirm.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Sep 2021

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female \>30 and \<80 years old. * Has a body mass index \>25 and \<45 kg/m2. * Previously diagnosed with prediabetes and/or T2D. * If not previously diagnosed, has a fasting blood glucose ≥ 100 mg/dL and/or HbA1c ≥ 5.7% Exclusion Criteria: * Morbidly obese patients (BMI \>45 kg/m2) and lean patients (BMI \<25 kg/m2) * Evidence of type 1 diabetes and diabetics requiring insulin therapy. * Subjects who have not been weight stable (\>2 kg weight change in past 3 months) * Subjects who have been recently active (\>30 min of moderate/high intensity exercise, 3 times/week). * Subjects who are smokers or who have quit smoking \<1 years ago * Subjects with abnormal estimated glomerular filtration rate (eGFR). * Hypertriglyceridemic (\>400 mg/dl) and hypercholesterolemic (\>260 mg/dl) subjects * Hypertensive (\>160/100 mmHg) * Subjects with a history of significant metabolic, cardiac, congestive heart failure, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or cancer that in the investigator's opinion would interfere with, alter the outcome measures, or impact subject safety. * Pregnant (as evidenced by positive urine pregnancy test) or nursing women. * Subjects with contraindications to participation in an exercise training program * Currently taking active weight suppression medication (e.g. phentermine,orlistat, lorcaserin, naltrexone-bupropion in combination, liraglutide, benzphetamine, diethylpropion, phendimetrazine) * Known hypersensitivity to perflutren (contained in Definity)

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Conditions

The condition(s) this trial relates to.

Behavior Motor Activity prediabetes syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus, type 2 Prediabetes

Contacts and locations

Locations

  • New Jersey Institute for Food, Nutrition, and Health

    New Brunswick, New Jersey, 08901, United States

  • Robert Wood Johnson University Hospital Clinical Research Center

    New Brunswick, New Jersey, 08901, United States

  • Rutgers University Loree Gymnasium

    New Brunswick, New Jersey, 08901, United States

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