New stent study aims to improve heart outcomes for all, especially diabetics

NCT ID NCT04475380

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how well the Xience Sierra drug-coated stent works in a broad group of heart disease patients, including those with diabetes or prediabetes. Over 1,700 participants received the stent during a routine procedure to open blocked arteries. Researchers tracked heart-related events like death, heart attack, or need for repeat procedures for up to two years to see if the stent is safe and effective in real-world, high-risk patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Xience Sierra everolimus-eluting stent
What this could lead to
If successful, this could confirm that the Xience Sierra stent is safe and effective for a wide range of heart disease patients, including those with diabetes.
What could go wrong
This is a completed observational study, not a randomized trial, so results may not prove superiority over other stents. Risks include typical stent complications like blood clots or re-narrowing.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Haga Ziekenhuis

    The Hague, Netherlands

  • Thoraxcentrum Twente

    Enschede, Netherlands

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