Coronary stenosis

This study looks at how a special balloon called the OPN balloon is used to open severely hardened or blocked heart arteries. Researchers will track 300 adults who need this procedure to see how well it works and what problems might happen. The goal is to learn the best ways to u…

This trial is testing a new coronary extension catheter designed to help doctors deliver balloons and stents more easily during percutaneous coronary intervention (PCI) for coronary artery disease. The study will enroll about 69 adults who need PCI and for whom the catheter is pl…

This study looks at the best timing for opening blocked arteries in people having a certain type of heart attack (NSTEMI) who have multiple blockages. About 1,014 participants will be randomly assigned to have all blockages fixed during the same procedure or to wait a few days be…

This study tests a new balloon coated with sirolimus (Virtue SAB) against an existing balloon coated with paclitaxel (AGENT DCB) for treating in-stent restenosis — when a previously placed stent in a heart artery becomes blocked again. About 740 people with one re-narrowed stent …

This study compares two ways to place stents in the left main coronary artery when there is a blockage at the opening of a branch. One method places a stent only in the blocked branch, while the other extends a stent from the main artery into the branch. Researchers will track 10…

This study tests whether using a computer simulation (virtual stenting) before placing stents in heart arteries can lead to better outcomes than the usual method guided by X-ray images alone. About 1,472 adults with coronary artery disease will be randomly assigned to either the …

This study is testing a new heart stent called Coroflex ISAR NEO in 1,000 people with narrowed heart arteries. The goal is to see how safe and effective it is compared to other stents in everyday medical practice. Researchers will track major heart problems like death, heart atta…

This study is tracking 1,000 people who receive the DESyne X2 drug-eluting stent to treat narrowed or blocked coronary arteries. Researchers are monitoring how often patients experience serious heart events like death, heart attack, or the need for another procedure. The goal is …

This study compares two advanced heart procedures—stenting guided by imaging and blood flow tests (PCI) versus bypass surgery (CABG)—in 1,500 people with diabetes and three blocked coronary arteries. The goal is to see which approach better prevents major events like death, heart…

This study tests whether a home-based cardiac rehab program delivered through a mobile app can reduce plaque buildup in the heart arteries of people with mild to moderate blockages. 176 participants will either get the app-based program (with exercise plans, diet advice, and ment…

This study tests whether using a tiny ultrasound camera inside the leg arteries during a procedure to open blockages can prevent major problems like amputation or the artery narrowing again. About 772 adults with severe peripheral artery disease (chronic limb-threatening ischemia…

This study looks at two different ways to use a heart-lung machine (ECMO) during high-risk heart procedures. One method sets up the machine just in case it's needed, while the other uses it from the start. The goal is to see which approach leads to fewer serious problems like dea…

This trial tests a new type of stent (Supraflex Cruz) combined with a shorter course of blood thinners (only 1-3 months of dual therapy, then just one drug) for people with a blockage in the left main coronary artery. The goal is to see if this approach reduces bleeding risks whi…

This study tests a special balloon coated with a drug (paclitaxel) to open blocked heart arteries. About 1,200 adults with coronary artery disease will receive either the Prevail balloon or another similar balloon. The goal is to see if the Prevail balloon is safe and works well …

This study compares a new artificial intelligence (AI) method that uses X-ray images to guide heart artery stenting against the standard invasive method. About 2100 adults with narrowed heart arteries will be randomly assigned to one of the two approaches. The goal is to see if t…

This study aims to see if using tiny cameras inside the heart's arteries during stent placement leads to better outcomes for people with complex coronary artery disease. About 11,000 adults in the Netherlands who need a stent for severe blockages will be included. The goal is to …

This registry is following 10,000 people who receive the BioFreedom Ultra stent, a device coated with the drug biolimus A9 to keep heart arteries open. The goal is to see how well the stent works in real-world patients, not just in controlled trials. Researchers will track proble…

This study compares a new dissolvable heart stent (Firesorb BRS) to a standard metal stent in 2000 people with coronary artery disease. The dissolvable stent is designed to support the artery temporarily and then disappear, potentially avoiding long-term risks of permanent stents…

This study looks at whether using a temporary mechanical heart pump during a high-risk heart procedure (PCI) can improve safety and outcomes. About 98 adults with weak hearts and complex blockages will be randomly assigned to receive the pump or standard care. The goal is to see …

This study tests a special balloon coated with two drugs to open blocked heart arteries in people with chest pain or minor heart attacks. The balloon is used instead of placing a new stent. About 30 participants will be followed for 12 months to see if the artery stays open and i…

This study looks at whether taking just one blood thinner (single antiplatelet therapy) is safer and as effective as taking two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a balloon procedure to open blocked heart arteries. About 576…

This study tests two methods to fix a common problem: a heart stent that hasn't opened fully (underexpansion). One method uses a balloon to push the stent open, the other uses shock waves (lithotripsy) to crack the blockage. About 80 people with narrowed stents will be randomly a…

This study compares two methods for guiding a second stent procedure in people whose drug-coated stents have re-narrowed. One method uses standard X-ray (angiography), the other adds detailed imaging from inside the artery. The goal is to see which approach leads to fewer major h…

This study looks at whether taking two blood thinners (ticagrelor plus aspirin) is better than aspirin alone for keeping bypass grafts open in people who had heart surgery after a heart attack. About 360 participants will be followed for 1 to 3 years, and their grafts will be che…

This study compares two types of drug-coated balloons (Selution sirolimus vs. SeQuent Please Neo paclitaxel) to treat narrowed coronary arteries in medium-small vessels. About 140 adults with stable angina or stabilized acute coronary syndrome will be enrolled. The main goal is t…

This study looks at whether people with chronic heart disease and a high risk of bleeding can stop taking antiplatelet drugs (blood thinners) one year after a balloon angioplasty procedure. Researchers will compare those who stop versus those who continue the medication, tracking…

This study tests whether a comprehensive treatment plan can reduce heart attacks and other serious events in people with rapidly-progressive coronary artery disease tied to inflammation. Researchers will compare each participant's outcomes before and after treatment. The study en…

This study looks at whether SGLT2 inhibitors (drugs like empagliflozin and dapagliflozin, typically used for diabetes) can prevent acute kidney injury caused by contrast dye used in heart X-rays and stent procedures. Researchers will review records of 4,000 patients who had these…

This trial tests a special balloon coated with sirolimus (a drug) to treat small arteries in the heart, compared to standard drug-eluting stents. About 1605 people with coronary artery disease will be randomly assigned to one of the two treatments. The goal is to see if the ballo…

This study is testing whether a new type of CT scan, called photon-counting CT, can do it all in one go for people who have had a coronary stent placed. The scan aims to check the stent and arteries, measure blood flow to the heart muscle, and assess heart function in a single ex…

This study tests a new technology called IVUS-FFR that uses ultrasound images from inside heart arteries to quickly check if a blockage is serious enough to need a stent. Unlike the current standard test, it doesn't require an extra pressure wire or medication that can cause disc…

This study tests whether artificial intelligence can detect early signs of coronary artery disease from standard chest CT scans that don't use contrast dye. Researchers will analyze scans from about 1,600 adults to see if the AI can identify dangerous plaque and blockages. If suc…

This study tests whether giving a set of nerve blocks (injections of numbing medicine) right after anesthesia but before surgery can reduce pain and the need for opioid painkillers after coronary artery bypass grafting. 56 adults scheduled for elective bypass surgery will be rand…

This study tests whether a specific nerve block, called the serratus posterior superior intercostal plane block, can reduce pain and opioid use after minimally invasive heart bypass surgery. Sixty adults undergoing this surgery will be randomly assigned to receive either the nerv…

This study tracks 500 adults with stable coronary artery disease or unstable angina who are undergoing a heart procedure called percutaneous coronary intervention (PCI) using a drug-coated balloon. Researchers are looking at how procedural details—specifically how long the balloo…

This study looks at whether advanced imaging can detect a hidden heart condition called cardiac amyloidosis in people with severe aortic valve stenosis. The condition can complicate treatment and recovery. Researchers will use echocardiography, CT, and SPECT/CT scans to check for…

This study will follow 20,000 patients with complex coronary artery disease to see how non-fatal complications during a heart procedure (stent placement) affect their risk of death over the long term. Researchers aim to identify which complications are most dangerous. The study d…

This study tests two improvements for heart catheterization done through a small artery in the wrist. First, it checks if a special patch can stop bleeding faster. Second, it sees if using ultrasound to guide the needle makes the procedure more successful. About 480 adults needin…

This study is observing 20,000 people undergoing routine heart or blood vessel procedures through the wrist (radial or ulnar artery). Researchers will track complications like artery blockage, spasm, and bleeding. The goal is to gather real-world data to improve safety and succes…

This observational study will enroll 10,000 adults who are already scheduled for a cardiac CT scan. Researchers will use artificial intelligence to analyze the scans, looking for subtle signs of dangerous plaque that might predict future heart attacks. Participants will also give…

This study reviews the long-term heart health of 1,500 patients who received a drug-eluting balloon to treat coronary artery disease between 2010 and 2025. Researchers will track major heart events like heart attacks, strokes, and repeat procedures. The goal is to better understa…

This study looks at how aging inside our cells might make heart arteries more prone to dangerous plaques. Researchers will measure DNA damage and other aging markers in 300 adults with different types of chest pain or heart attacks. The goal is to find better ways to predict who …

This study is observing 10,000 people with severe narrowing in the left main coronary artery, a critical heart vessel. Researchers are comparing the long-term results of three approaches: medication, stenting with drug-coated stents, and bypass surgery. The goal is to see which w…

This study follows 30,000 adults with coronary artery disease to see how different risk factors affect their long-term survival. Researchers will track deaths from any cause and from heart problems specifically. The goal is to better understand what influences outcomes in real-wo…

This study looks at whether a special heart ultrasound measurement, called global longitudinal strain (GLS), can predict if a person will have trouble coming off the heart-lung machine during heart surgery. About 213 adults having planned heart surgery will have their hearts meas…

This observational study will follow 1,000 patients in Poland who undergo a procedure to open completely blocked heart arteries. Researchers will collect data on success rates, complications, and long-term outcomes to understand what works best in everyday practice. The goal is t…

This study follows 4000 people with coronary artery disease who have had special imaging of their heart arteries. Researchers will track them for 5 years to see how well the images predict serious events like heart attacks or the need for repeat procedures. The goal is to improve…

This registry is following 5,000 people who had a heart attack and were treated with medications, stents, or bypass surgery at Asan Medical Center in Korea. Researchers are tracking deaths, repeat heart attacks, and other major events over the long term to understand which treatm…

This study is tracking 500 patients who received rotational atherectomy, a procedure that uses a tiny rotating burr to grind away hardened plaque in heart arteries. Researchers want to see how safe and effective it is in real-world settings. The main goal is to measure how many p…

This study compares two methods for opening completely blocked heart arteries: antegrade dissection and re-entry (ADR) versus a retrograde approach. Researchers will measure procedure time, success rates, complications, and even doctor stress levels. 74 participants with difficul…

This trial tests whether using a wrist artery access point closer to the hand (distal radial) is safer than the usual wrist access for complex heart procedures like opening blocked arteries. About 708 adults with stable or unstable heart conditions will be randomly assigned to on…

This study looks at a fast-progressing type of coronary artery disease that may be driven by inflammation. Researchers will compare 20 patients with this condition to 10 patients with typical heart disease, using lab tests, imaging, and physical assessments. The goal is to better…

This study aims to learn more about heart disease that is linked to inflammation but does not progress quickly. Researchers will follow 120 adults with this condition to track their treatments and health outcomes, such as heart attacks or the need for procedures. The goal is to b…

This study is collecting information from 3,000 people who receive a special drug-coated balloon to open blocked heart arteries. The goal is to see how effective and safe the balloon is in real-world use, including for different types of blockages and patient conditions. Research…

This study tests whether artificial intelligence can evaluate how well surgeons perform a key step in heart bypass surgery. Researchers will compare AI scores to those from human experts. The trial involves 284 patients undergoing bypass grafting and aims to see if AI can reliabl…