Coronary stenosis

This study tests a new laser system designed to vaporize plaque in blocked coronary arteries before doctors place a stent. The trial compares the new laser device to an existing one in about 218 people with severe heart artery narrowing. The main goal is to see if the new system …

This trial tests a new device called the Angimis Atherectomy System, which uses laser energy to break up plaque in coronary arteries that are too narrow or hardened for standard balloon or stent procedures. The study enrolls adults with coronary artery disease who have at least o…

This study compares a drug-coated balloon (DCB) to a drug-eluting stent (DES) for treating new blockages in heart arteries. About 1,548 adults with stable or unstable angina, old heart attacks, or silent ischemia will be randomly assigned to one of the two treatments. The main go…

This study tests whether drinking a specially designed milk every day for a year can reduce the chance of stents narrowing again and prevent further heart problems in people who have had a first heart attack. About 140 adults who recently had a stent placed will be randomly assig…

This registry will follow 2000 people with complex coronary artery disease who receive the Inspiron EVO drug-eluting stent. The stent is designed to be easier to deliver and stronger than standard stents. Researchers will track how well the stent works and whether it reduces hear…

This study reviews medical records of 252 patients who received a drug-coated balloon to treat blocked heart arteries. The goal is to see how safe and effective the balloon is over two years. Researchers will track heart-related deaths, heart attacks, and the need for repeat proc…

This study tests if using a drug-coated balloon along with a stent works better than a stent alone for people with complex blockages in the left main coronary artery. About 186 adults with this condition will be randomly assigned to one of two treatments. The goal is to see which…

This study compares two ways of preparing a re-narrowed heart artery before using a drug-coated balloon to open it. In 500 adults with in-stent restenosis, half will get standard balloon prep and half will get a more aggressive prep with special cutting or scoring balloons. The g…

This study tests whether using a laser to clear re-narrowed heart stents works better than standard balloon treatment. About 1,260 adults with drug-eluting stent restenosis will be enrolled. The goal is to see if laser-assisted angioplasty reduces heart-related deaths, heart atta…

This study looks at whether older adults (65+) who get a heart stent can safely stop one of their blood thinners (aspirin) after just 7 days instead of the usual 3 to 12 months. The goal is to see if this shorter treatment reduces bleeding risks without increasing heart attacks, …

This study explores whether a newer type of SPECT/CT scan can accurately measure blood flow in the heart, similar to the more expensive and less available PET scan. Researchers will compare the two imaging methods in 30 adults with coronary artery disease who are already schedule…

This study tests whether an artificial intelligence system called AngioAI+ can accurately diagnose two types of coronary artery disease using standard angiogram images. The research involves 620 adults with suspected coronary artery disease who are already scheduled for an angiog…

This study tests whether a simple, 1-minute electrocardiogram (ECG) analyzed by artificial intelligence can accurately detect significant blockages in the heart's arteries. Researchers will compare the AI's predictions against standard imaging tests in 400 adults. If successful, …

This trial tests whether cutting out a small fibrous structure called the Ligament of Marshall during minimally invasive heart bypass surgery can prevent new-onset atrial fibrillation (an irregular heartbeat) that often occurs after the operation. The study will include 628 adult…

This study will test two different surgical techniques used during heart bypass surgery to see which one better prevents a common complication called atrial fibrillation (irregular heartbeat). The trial will involve 122 adults having their first planned bypass surgery. Researcher…

This trial tests whether a targeted nerve block, called an adductor canal block, can reduce leg pain after coronary artery bypass grafting (CABG) when a leg vein is used as a graft. About 120 adults scheduled for CABG will receive either the block with a numbing medication or a s…

This study tests whether injecting a long-acting numbing medicine (bupivacaine) through chest tubes can safely reduce pain and lower the need for strong painkillers after heart bypass surgery. Sixty adults will receive either the numbing medicine or a saltwater placebo whenever t…

This study is a large, real-world registry that will include over 10,000 people with coronary artery disease from more than 50 hospitals across China. The goal is to see how often a software tool called QFR, which analyzes angiogram images to guide treatment decisions, is used in…

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

This study tests a personalized, digitally supported prehabilitation program for adults waiting for elective cardiac surgery. Participants receive education, psychosocial support, nutritional advice, and home-based exercise guidance during the routine 6-10 week preoperative perio…

This study will follow 600 adults having off-pump heart bypass surgery to see how often memory and thinking problems occur afterward. Participants take a simple thinking test before and after surgery. The goal is to understand what factors might increase the risk of these problem…

This study tests two different computer alerts designed to encourage doctors to refer heart patients to cardiac rehab. About 7,000 adults who had heart surgery or a stent in the past year will take part. The goal is to see if these simple reminders increase the number of people w…

This pilot study tests whether a larger trial comparing two methods of harvesting the left internal mammary artery (LIMA) for heart bypass surgery is feasible. About 35 adults having planned bypass surgery will be randomly assigned to either the skeletonized method (isolating the…

This study will follow 1000 adults in China with severe coronary artery disease who are too high-risk for bypass surgery and need complex angioplasty. Researchers will collect data on their health, procedures, and outcomes for one year to see what factors affect survival and comp…

This study will follow 1,800 people who had a stent placed in their heart arteries using a special camera (OCT). Researchers want to see if new measurements from routine angiograms can better predict future heart problems like heart attacks or chest pain. The goal is to improve h…

This study will follow 600 people who need either bypass surgery (CABG) or a stent (PCI) to open blocked heart arteries. Researchers will test memory and thinking skills before the procedure and again at 1 month, 1 year, and 2 years after. The goal is to see if one approach leads…

This study looks at whether a special MRI scan can predict if patients will develop an irregular heartbeat (atrial fibrillation) after heart bypass surgery. About 100 adults scheduled for bypass will get an MRI before surgery and wear a heart monitor for a year. The goal is to fi…

This study looks at ways to help surgeons use more artery grafts instead of vein grafts during heart bypass surgery, since artery grafts last longer. It will involve about 8,700 patients across many hospitals. The study does not test a new drug or device, but rather tests trainin…

This study will compare three different fluids used to protect the heart during coronary artery bypass surgery. Researchers will measure tiny particles and immune system markers in the blood to see which fluid causes the least heart muscle injury. The goal is to find the safest a…

This study will create a national registry to collect data on 3,000 adults undergoing coronary artery bypass graft (CABG) surgery in Saudi Arabia. The goal is to track complications, recovery, and quality of life for one year after surgery. This information will help hospitals im…

This study aims to understand why some people's coronary artery disease gets worse quickly while others' stays stable. Researchers will compare medical history, lab results, and imaging from 52 patients—34 with rapidly progressive disease and 18 with non-rapidly progressive disea…

This study tests whether using very low radiation doses combined with special software can produce clear images of the heart's arteries. About 50 adults scheduled for a standard heart angiogram will have extra images taken with the new low-radiation method. The goal is to see if …

This study will compare how well heart and lung function recover after robot-assisted heart surgery versus traditional open-heart surgery. Researchers will measure exercise capacity and breathing in 80 patients before and after surgery. The goal is to see if the less invasive rob…