Coronary stenosis

This study tests a new device that uses shock waves to break up calcium deposits in heart arteries before placing a stent. About 335 adults with coronary artery disease will receive this treatment at up to 55 US sites. The goal is to see if the device helps stents work better and…

This study tests a special balloon coated with a drug to treat heart arteries that have narrowed again after a stent was placed. About 600 adults with this condition will be randomly assigned to receive either the drug-coated balloon or a standard balloon procedure. The goal is t…

This study tests a special balloon coated with the drug paclitaxel to treat in-stent restenosis, where a previously placed stent in a heart artery narrows again. Twenty adults who have this condition will receive the balloon treatment or standard care. Researchers will check if t…

This trial looks at the best time to reopen other blocked arteries in people who have just had a major heart attack (STEMI) and have multiple narrowed heart arteries. Participants are randomly assigned to have all blockages fixed right away or in a separate procedure later. A spe…

This study is testing a paclitaxel-coated balloon to open small coronary arteries in people with heart disease who also have a high risk of bleeding. About 501 participants will receive the balloon treatment and then take blood thinners for either the standard duration or just 7 …

This trial tests whether a new device called OmniHeart 4.0 can safely support the heart during high-risk angioplasty, compared to the standard ECMO machine. About 254 patients will be randomly assigned to receive either the OmniHeart or ECMO. Researchers will track major heart an…

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approac…

This study tests whether using a special imaging tool called OCT during stent placement leads to fewer heart problems over two years compared to standard methods. About 1,200 adults with blocked heart arteries that need complex stenting are taking part. The goal is to see if OCT …

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study tests a newer drug-coated stent (Resolute Onyx) against an older one (Resolute Integrity) in 550 people with blocked heart arteries in China. The goal is to see if the new stent works better at keeping arteries open after angioplasty. Participants receive one of the tw…

This study tests a special stent coated with a drug called zotarolimus to treat people with blocked heart arteries. The stent is placed during a procedure to open the artery and slowly releases medication to prevent re-blockage. About 591 participants in China are being followed …

This study tests a temporary heart pump called Impella ECP in 100 adults undergoing high-risk angioplasty. The pump helps maintain blood flow during the procedure. Researchers are checking if the device is safe and works as intended, with follow-up for 30 days after the procedure…

This study tests whether using intravascular ultrasound (IVUS) to guide a specific stenting technique (DK crush) leads to fewer heart problems than standard angiography guidance. About 556 adults with complex coronary bifurcation lesions will be randomly assigned to one of the tw…

This study compares using a manual clot-removal catheter (Export) before standard balloon angioplasty versus angioplasty alone in 300 heart attack patients with completely blocked arteries. The goal is to see if removing the clot first improves blood flow and reduces in-hospital …

This study tests whether a comprehensive program of lifestyle changes (diet, exercise, education) plus aggressive cholesterol-lowering drugs, guided by PET heart scans, can reduce heart attacks and deaths better than standard medical care. Over 1,000 adults with suspected or know…

This study tests whether a sirolimus-coated balloon works as well as a standard drug-eluting stent for opening narrowed heart arteries. About 1,820 adults with coronary artery disease will be randomly assigned to receive either the balloon or the stent during a routine angioplast…

This study compares a new, smaller heart pump called NyokAssist to a standard balloon pump in people having high-risk heart procedures to open blocked arteries. The goal is to see if the new pump reduces serious heart and brain complications. About 236 adults will take part in th…

This study tests a special balloon coated with the drug sirolimus to treat in-stent restenosis, where a previously placed stent in a heart artery becomes blocked again. About 418 adults with this condition will be randomly assigned to receive either the drug-coated balloon or sta…

This study looks at whether a special laser can help open heart arteries that are too hard or blocked for standard balloon treatment. About 230 adults with severe coronary artery disease will receive the laser procedure and be followed for one year. The goal is to see if the lase…

This early study tests a new stent that releases a drug to prevent artery re-narrowing in 30 people with coronary artery disease. The stent is placed during a routine procedure to prop open blocked heart vessels. Researchers will check if the artery stays open after 13 months and…

This study planned to test whether taking two blood vessel-relaxing drugs (isosorbide mononitrate and amlodipine) for 24 weeks after coronary bypass surgery could prevent failure of the radial artery graft. The trial was withdrawn before enrolling any participants, so no data wer…

This study compares a new drug-coated balloon (Genoss SCB) to an existing one (SeQuent Please NEO) for treating coronary arteries that have re-narrowed after stenting. About 94 adults with this condition will be randomly assigned to receive one of the two balloons during a standa…

This study looks at whether certain blood markers can identify people without significant coronary artery disease, avoiding the need for more invasive tests. Researchers will enroll 1000 adults referred for a CT scan of the heart. The goal is to see if these biomarkers can accura…

This study looks at whether using a special camera called optical coherence tomography (OCT) during heart artery procedures helps doctors make better decisions and get better results. About 3,200 people with various heart conditions will be included. The goal is to see if OCT gui…

This large Phase 3 study tests whether inclisiran, a twice-yearly injection, can prevent major heart problems like heart attacks, strokes, and heart-related death in people at high risk who have not yet had such an event. Over 14,000 participants are receiving either inclisiran o…

This study tests whether a small shot of nitroglycerin under the skin can widen the wrist artery, making it easier for doctors to insert a tube for heart procedures. It involves 1,400 adults with coronary artery disease scheduled for heart catheterization. The goal is to reduce t…

This study tests a new way to find unstable plaques in the heart arteries of people who come to the emergency room with chest pain but are not having a heart attack. Researchers use a simple calcium scan to group patients by risk, then follow up with special PET scans to see if p…

This study involves 3,600 people who have had a heart stent placed. Researchers want to see if a special cholesterol test (VAP) can help predict when the artery narrows again. Participants provide a blood sample from routine care, and no extra blood draws are needed. The goal is …

This study looks at whether artificial intelligence can improve predictions of serious heart events in people with chest pain. Researchers will analyze stress echocardiogram results and routine medical data from about 2,281 adults. No extra visits or tests are needed for particip…

This study tests a new sensor worn on the skin that measures lactate levels without needles. It involves 20 adults recovering from heart bypass or valve surgery. The goal is to see if the sensor works as well as standard blood tests, which could make monitoring more comfortable a…

This study follows 400 people who had a stent placed in the left main coronary artery. Half get a routine angiogram 6 months later, while the other half have only clinical follow-up. Researchers want to see if the extra imaging reduces the chance of death, heart attack, or stroke…

This study was designed to test a new catheter that takes two types of pictures inside heart arteries at the same time—using sound and light. The goal was to see if this hybrid approach is safer and better at identifying fatty plaques that could cause heart attacks compared to st…