New balloon treatment may shorten blood thinner use for heart patients

NCT ID NCT06321757

Ongoing Disease control Sponsor: Fundación EPIC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This study is testing a paclitaxel-coated balloon to open small coronary arteries in people with heart disease who also have a high risk of bleeding. About 501 participants will receive the balloon treatment and then take blood thinners for either the standard duration or just 7 days. The goal is to see if the balloon works well and if a shorter course of blood thinners is safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: paclitaxel-coated balloon
What this could lead to: If successful, this could show that a drug-coated balloon with just 7 days of blood thinners is safe and effective for people with small heart arteries and high bleeding risk.
What could go wrong: This is an observational study, not a randomized trial, so results may be less definitive. The short blood thinner regimen might still carry bleeding or clotting risks.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder coronary stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE

Contacts and locations

Locations

Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello

Palermo, 90146, Italy
Clinica Mediterranea

Naples, 08122, Italy
Hospital Clinico Universitario de Valladolid

Valladolid, 47003, Spain
Hospital General Universitario Dr. Balmis

Alicante, 03010, Spain
Hospital General Universitario de Albacete

Albacete, 02008, Spain
Hospital General Universitario de Ciudad Real

Ciudad Real, 13005, Spain
Hospital Universitari de Bellvitge

L'Hospitalet de Llobregat, 08907, Spain
Hospital Universitario Clinico San Cecilio

Granada, 18016, Spain
Hospital Universitario Juan Ramon Jimenez

Huelva, 21005, Spain
Hospital Universitario Virgen del Rocío

Seville, 41013, Spain
Hospital Universitario Y Politecnico La Fe

Valencia, 46026, Spain
Hospital Universitario de Canarias

San Cristóbal de La Laguna, Spain
Hospital Universitario de Cruces

Barakaldo, 49803, Spain
Hospital Universitario de Gran Canaria Doctor Negrín

Las Palmas de Gran Canaria, 35010, Spain
Hospital Universitario de La Princesa

Madrid, 28006, Spain
Hospital Universitario de Leon

León, 24071, Spain
ULS Santa Maria

Lisbon, Portugal
Ulslo-H.Santa Cruz

Carnaxide, Portugal
University Hospital HM Montepríncipe

Boadilla del Monte, 28660, Spain

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