Heart bypass graft drug combo trial pulled before it began

NCT ID NCT06730945

Terminated Disease control Sponsor: Ruijin Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study planned to test whether taking two blood vessel-relaxing drugs (isosorbide mononitrate and amlodipine) for 24 weeks after coronary bypass surgery could prevent failure of the radial artery graft. The trial was withdrawn before enrolling any participants, so no data were collected. The intended participants were adults who had just received a radial artery graft during bypass surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: isosorbide mononitrate and amlodipine
What this could lead to: If it had worked, this could point toward a simple oral treatment to keep radial artery grafts open longer after bypass surgery.
What could go wrong: The trial was withdrawn before any participants enrolled, so no results are available. Even if conducted, the treatment might not reduce graft failure and could cause low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY BYPASS GRAFT SURGERY (CABG) GRAFT FAILURE RADIAL ARTERY GRAFTS

Contacts and locations

Locations

Ruijin Hospital Shanghai Jiao Tong University School of Medicine

Shanghai, China

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