GRAFT FAILURE

This early-phase study tests whether the drug emapalumab can prevent the body from rejecting a stem cell transplant in patients at high risk for graft failure. The study will enroll 20 participants and measure how well the drug works and how it behaves in the body. The goal is to…

This study tests whether giving extra donor stem cells (a CD34+ boost) can help people whose bone marrow transplant isn't working well or has failed. About 21 adults who had a stem cell transplant will receive this boost. The main goals are to see if it safely restores normal blo…

This study tests a stem cell transplant from a donor to treat people with severe blood disorders like sickle cell disease and thalassemia. About 62 participants will receive the transplant and be monitored for side effects like graft-versus-host disease. The goal is to control th…

This study tests whether a daily low dose of colchicine, a medicine usually used for gout, can help prevent the failure of bypass grafts in people who have had coronary artery bypass surgery (CABG). About 100 adults will take colchicine for one year after surgery and have CT scan…

This study tests whether adding the drug ruxolitinib to a standard stem cell transplant regimen can lower the chance of transplant failure in children and young adults with severe sickle cell disease. About 24 participants aged 12-45 will receive a transplant from a half-matched …

This study looks at 150 women having heart bypass surgery to see which type of graft—a vein from the leg or an artery from the arm—works better for the second most important heart artery. The goal is to find out which graft stays open longer and causes fewer problems. Participant…

This study aims to understand why vein grafts used in heart bypass surgery sometimes fail, leading to heart attacks or strokes. Researchers will use advanced total-body PET scans to look at inflammation and clotting inside the grafts. The study will involve 70 adults who recently…