New hope for sickle cell: drug combo aims to boost transplant success
NCT ID NCT07252050
First seen Nov 26, 2025 · Last updated May 13, 2026 · Updated 17 times
Summary
This study tests whether adding the drug ruxolitinib to a standard stem cell transplant regimen can lower the chance of transplant failure in children and young adults with severe sickle cell disease. About 24 participants aged 12-45 will receive a transplant from a half-matched donor and be followed for two years. The goal is to improve survival without needing a second transplant or facing other serious complications.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Healthcare of Atlanta
RECRUITINGAtlanta, Georgia, 30329, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Colorado
NOT_YET_RECRUITINGAurora, Colorado, 80045, United States
Contact
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Children's Hospital of Philadelphia
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
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Manning Family Children's
NOT_YET_RECRUITINGNew Orleans, Louisiana, 70118, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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