Heart bypass patients: does a stronger blood thinner keep grafts working longer?

NCT ID NCT04783701

Recruiting now Disease control Sponsor: University Hospital, Linkoeping Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether taking two blood thinners (ticagrelor plus aspirin) is better than aspirin alone for keeping bypass grafts open in people who had heart surgery after a heart attack. About 360 participants will be followed for 1 to 3 years, and their grafts will be checked with a special CT scan. The goal is to see if the stronger blood-thinning regimen reduces graft blockages.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ticagrelor (antiplatelet drug) plus aspirin, compared to aspirin alone
What this could lead to: If it works, this could show that adding ticagrelor to aspirin helps keep bypass grafts open longer after heart surgery, potentially reducing the need for repeat procedures.
What could go wrong: This is a relatively small, early-phase study (360 participants) and results may not apply to all patients. The benefit of dual therapy must be weighed against a higher risk of bleeding.

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Conditions

The condition(s) this trial relates to.

acute coronary syndrome coronary restenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE CORONARY SYNDROME CORONARY BYPASS STENOSIS

Contacts and locations

Locations

Dep of Vascular and Thoracic Surgery
ACTIVE_NOT_RECRUITING

Örebro, Sweden
Department of Cardiothoracic Surgery Karolinska University Hospital
ENROLLING_BY_INVITATION

Stockholm, Sweden
Department of Heart Disease, Haukeland University Hospital
ENROLLING_BY_INVITATION

Bergen, Norway
Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine
ENROLLING_BY_INVITATION

Gothenburg, Sweden
St Olavs University Hospital
NOT_YET_RECRUITING

Trondheim, Norway
University Hospital Linköping
RECRUITING

Linköping, Östergötland County, 58185, Sweden

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