Can a tailored Blood-Thinner combo prevent second heart attacks without causing bleeding?
NCT ID NCT05638867
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This trial tests whether adding a low-dose blood thinner (rivaroxaban) to standard antiplatelet therapy for the first three months after a heart stent procedure can reduce the risk of future heart attacks, strokes, and other cardiovascular events in high-risk patients. Participants are selected based on elevated D-dimer levels or a high PARIS risk score, indicating increased clotting risk. The study compares this short-term triple therapy followed by standard dual antiplatelet therapy against standard dual antiplatelet therapy alone, while closely monitoring for bleeding complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A short course of low-dose rivaroxaban added to aspirin and clopidogrel, followed by standard dual antiplatelet therapy
- What this could lead to
- If effective, this approach could reduce the risk of heart attacks, strokes, and other major cardiovascular events in high-risk patients after stent placement, without a significant increase in dangerous bleeding.
- What could go wrong
- Adding a blood thinner may increase bleeding risk, and the benefit may not outweigh this risk. The trial is large but results are not yet known, and the specific high-risk patient selection may not generalize to all ACS patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chinese Academy of Medical Sciences, Fuwai Hospital
RECRUITINGBeijing, Beijing Municipality, 100037, China
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