Can a tailored Blood-Thinner combo prevent second heart attacks without causing bleeding?

NCT ID NCT05638867

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This trial tests whether adding a low-dose blood thinner (rivaroxaban) to standard antiplatelet therapy for the first three months after a heart stent procedure can reduce the risk of future heart attacks, strokes, and other cardiovascular events in high-risk patients. Participants are selected based on elevated D-dimer levels or a high PARIS risk score, indicating increased clotting risk. The study compares this short-term triple therapy followed by standard dual antiplatelet therapy against standard dual antiplatelet therapy alone, while closely monitoring for bleeding complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
A short course of low-dose rivaroxaban added to aspirin and clopidogrel, followed by standard dual antiplatelet therapy
What this could lead to
If effective, this approach could reduce the risk of heart attacks, strokes, and other major cardiovascular events in high-risk patients after stent placement, without a significant increase in dangerous bleeding.
What could go wrong
Adding a blood thinner may increase bleeding risk, and the benefit may not outweigh this risk. The trial is large but results are not yet known, and the specific high-risk patient selection may not generalize to all ACS patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Chinese Academy of Medical Sciences, Fuwai Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100037, China

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