Could a cheap pill fix stiff arteries in insulin resistance?

NCT ID NCT03837626

Completed Disease control Sponsor: University of Missouri-Columbia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether amiloride, a drug that blocks sodium channels, can improve artery stiffness and blood vessel function in people who are overweight and insulin resistant. 137 men and women (pre- and postmenopausal) took either amiloride or a placebo daily for 6 months. The main goal was to see if the drug could reduce a key measure of arterial stiffness, which is a risk factor for heart disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Amiloride (a pill that blocks sodium channels in cells)
What this could lead to: If successful, this could point toward a simple, low-cost way to reduce artery stiffness and heart disease risk in people with insulin resistance.
What could go wrong: This is a small, completed trial. The drug may not show clear benefits, or results may not apply to all groups. Amiloride can affect kidney function and electrolyte balance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Insulin Resistance Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INSULIN RESISTANCE OVERWEIGHT AND OBESITY

Contacts and locations

Locations

University of Missouri Hospital and Clinics

Columbia, Missouri, 65201, United States

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