Can decades of lifting weights keep the Brain's muscle signals young?

NCT ID NCT06820658

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This study compares how well the brain communicates with muscles in adults aged 60-85 who are either long-term resistance exercisers or untrained. Using transcranial magnetic stimulation (TMS) and electromyography (EMG), researchers will measure the strength of nerve-to-muscle signals. The goal is to understand whether regular exercise preserves the nervous system's control over muscles in older age.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Neuromuscular testing using Transcranial Magnetic Stimulation (TMS) and Electromyography (EMG), plus DEXA scans
What this could lead to: If successful, this could reveal how lifelong exercise shapes the brain's control of muscles in older adults, potentially guiding future fitness or rehabilitation strategies.
What could go wrong: This is an observational comparison, not a treatment trial, so it won't directly change health outcomes. Results may be limited by the small sample size and the specific age group studied.

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Conditions

The condition(s) this trial relates to.

Insulin Resistance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY INSULIN RESISTANCE

Contacts and locations

Locations

Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States

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