Blocking stress hormones may reveal why overeating leads to fat gain

NCT ID NCT06556277

Completed Knowledge-focused Sponsor: Eleonora Seelig Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether stress hormones (glucocorticoids) released after eating contribute to fat gain in overweight people. Twenty-three overweight men were given either a drug combination that blocks these hormones or a placebo while overeating for a week. Researchers measured changes in body fat to understand the hormone's role.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metyrapone and hydrocortisone
What this could lead to: If successful, this could help explain why some people gain fat when overeating, potentially pointing to new ways to prevent obesity.
What could go wrong: This is a small, early-stage study with only 23 participants, so results may not apply to everyone. It is designed to understand biology, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hyperphagia Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLUCOCORTICOIDS OVEREATING OVERWEIGHT AND OBESITY

Contacts and locations

Locations

University Hospital Basel

Basel, Canton of Basel-City, 4031, Switzerland

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