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Can changing when and what you eat trick your body into making less fat?

NCT ID NCT02075710

Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This study investigates how the amount of sugar or fat in a person's diet, along with how many meals they eat each day, influences the body's fat production, blood fat levels, and liver fat storage. Overweight adults aged 20–65 will follow different meal patterns—ranging from two large meals to eight small meals—with either high-sugar or high-fat content. The goal is to understand which combinations may lower cardiovascular risk by altering fat metabolism.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
controlled diets varying in sugar/fat content and meal frequency
What this could lead to
If it works, this could point toward dietary strategies to reduce liver fat and cardiovascular risk.
What could go wrong
This is a small, early-stage study in a controlled setting, so findings may not apply to real-world eating habits or diverse populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

33 people

The number who actually took part.

Started

Jul 2013

Finished

May 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * overweight or obese men and women * ages 20-65 years Exclusion Criteria: * pregnancy or lactation within the past six months * type 1 or 2 diabetes mellitus\] * AST and ALT above upper limit of normal (ULN) * fasting triglyceride or total cholesterol levels \>ULN * Hgb below the lower of limit of normal * positive HIV antibody test or hepatitis serologies * use of any antidiabetic medications or lipid-lowering drugs * history of surgery for obesity * change in body weight \>5% within preceding 6 months (self report) * claustrophobia, presence of metal implants * weight over 350 lbs

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Overweight and obesity

Contacts and locations

Locations

  • University of California, San Franciso, San Francisco General Hospital

    San Francisco, California, 94110, United States

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