Leucine: the Muscle-Saving supplement for dieters?
NCT ID NCT07583875
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether taking extra leucine, a natural amino acid, helps preserve muscle during a 4-week alternate-day fasting program in overweight young men. Participants were randomly assigned to one of four doses of leucine. Researchers measured body composition, blood markers, and other health indicators before and after the program. The goal was to see if higher leucine doses better protect muscle mass during weight loss.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
leucine (a dietary supplement)
What this could lead to
If it works, this could point toward a simple dietary supplement to help people lose fat while keeping muscle during fasting.
What could go wrong
This is a small, completed trial in young men only, so results may not apply to women or older adults. The effect of leucine on muscle maintenance may be small or absent.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Nanyang Technological University
Singapore, 637616, Singapore