Leucine: the Muscle-Saving supplement for dieters?

NCT ID NCT07583875

Completed Disease control Sponsor: Nanyang Technological University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study tested whether taking extra leucine, a natural amino acid, helps preserve muscle during a 4-week alternate-day fasting program in overweight young men. Participants were randomly assigned to one of four doses of leucine. Researchers measured body composition, blood markers, and other health indicators before and after the program. The goal was to see if higher leucine doses better protect muscle mass during weight loss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: leucine (a dietary supplement)
What this could lead to: If it works, this could point toward a simple dietary supplement to help people lose fat while keeping muscle during fasting.
What could go wrong: This is a small, completed trial in young men only, so results may not apply to women or older adults. The effect of leucine on muscle maintenance may be small or absent.

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Conditions

The condition(s) this trial relates to.

Intermittent Fasting Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BMI >= 23 OVERWEIGHT AND OBESE ADULTS

Contacts and locations

Locations

Nanyang Technological University

Singapore, 637616, Singapore

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