16-Hour fast may sharpen aging brains, small study hopes

NCT ID NCT05732935

Completed Symptom relief Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This study tests whether time-restricted eating (fasting for 16 hours each day) can improve memory, thinking, and overall well-being in overweight adults aged 65 and older who are worried about their memory. Over 24 weeks, participants either follow the fasting plan or join a healthy aging group. The goal is to see if this simple lifestyle change can help protect the brain as we age.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: time-restricted eating (16-hour daily fasting)
What this could lead to: If it works, this could point toward a simple, drug-free way to help protect memory and thinking in older adults who are overweight.
What could go wrong: This is a small, early-stage study with only 52 participants. The results may not apply to everyone, and sticking to a 16-hour fast every day can be hard to maintain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Intermittent Fasting Obesity obesity disorder Overweight subjective cognitive decline

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE OVERWEIGHT AND OBESITY TIME RESTRICTED FEEDING

Contacts and locations

Locations

Clinical and Translational Research Building - Institute on Aging Suite

Gainesville, Florida, 32603, United States

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