Anti-Inflammatory pill may rewire food choices in overweight people
NCT ID NCT05785429
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether colchicine, a common anti-inflammatory drug, can change how the brain values effort and reward when making food choices. 59 overweight women with mild inflammation took either colchicine or a placebo daily for 12 weeks. Researchers used brain scans and behavior tests to see if the drug made them more willing to work for healthier, lower-calorie foods.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
colchicine
What this could lead to
If it works, this could point toward a treatment that helps people with overweight make healthier food choices by reducing inflammation.
What could go wrong
This is a small, early-stage study (59 people) that only looked at brain activity and behavior, not weight loss. Results may not apply to everyone, and colchicine can cause side effects like stomach upset.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Donders Centre for Cognitive Neuroimaging
Nijmegen, 9525EN, Netherlands