Anti-Inflammatory pill may rewire food choices in overweight people

NCT ID NCT05785429

Completed Knowledge-focused Sponsor: Donders Centre for Cognitive Neuroimaging Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether colchicine, a common anti-inflammatory drug, can change how the brain values effort and reward when making food choices. 59 overweight women with mild inflammation took either colchicine or a placebo daily for 12 weeks. Researchers used brain scans and behavior tests to see if the drug made them more willing to work for healthier, lower-calorie foods.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: colchicine
What this could lead to: If it works, this could point toward a treatment that helps people with overweight make healthier food choices by reducing inflammation.
What could go wrong: This is a small, early-stage study (59 people) that only looked at brain activity and behavior, not weight loss. Results may not apply to everyone, and colchicine can cause side effects like stomach upset.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Inflammation Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVERWEIGHT AND OBESITY

Contacts and locations

Locations

Donders Centre for Cognitive Neuroimaging

Nijmegen, 9525EN, Netherlands

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