Could flickering lights and tones help fight Alzheimer's? major trial underway

NCT ID NCT05637801

Ongoing Disease control Sponsor: Cognito Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) version. The goal is to see if this sensory stimulation can preserve memory and daily living skills better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Spectris™ AD device (sensory stimulation via light and sound)

What this could lead to

If it works, this could offer a non-drug, at-home treatment to slow memory and daily function loss in Alzheimer's disease.

What could go wrong

This is a pivotal study, but the device is still experimental. It may not show meaningful benefit over sham, and daily use for a year requires commitment.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Alzheimer disease 10 Alzheimer disease 11 Alzheimer disease 12 Alzheimer disease 13 Alzheimer disease 14 Alzheimer disease 16 Alzheimer disease 17 Alzheimer disease 18 Alzheimer disease 19 Alzheimer disease 2 Alzheimer disease 3 Alzheimer disease 4 Alzheimer disease 5 Alzheimer disease 6 Alzheimer disease 7 Alzheimer disease 8 Alzheimer disease 9 Alzheimer disease type 1 Alzheimer disease without neurofibrillary tangles Cognitive Dysfunction dementia early-onset autosomal dominant Alzheimer disease follicular lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

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Locations

ATP Clinical Research, Inc.

Costa Mesa, California, 92626, United States
Advanced Research Center, Inc

Anaheim, California, 92805, United States
Alphab Global Research

Jupiter, Florida, 33458, United States
Alzheimer's Memory Center - AMC Research

Matthews, North Carolina, 28105, United States
Aqualane Clinical Research

Naples, Florida, 34105, United States
Arrow Clinical Trials

Daytona Beach, Florida, 32117, United States
Axiom Clinical Research of Florida

Tampa, Florida, 33609, United States
Banner Sun Health Research Institute

Sun City, Arizona, 85351, United States
Barrow Neurological Institute

Phoenix, Arizona, 85013, United States
Boston Center for Memory

Newton, Massachusetts, 02459, United States
Boston Clinical Trials, Inc.

Boston, Massachusetts, 02131, United States
Brain Matters Research

Delray Beach, Florida, 33445, United States
Brain Matters Research

Stuart, Florida, 34997, United States
CCT Research - Foothills Research Center

Phoenix, Arizona, 85044, United States
CCT Research - Gilbert Neurology Partners

Gilbert, Arizona, 85297, United States
CCT Research - Papillion Research Center

Papillion, Nebraska, 68046, United States
Center for Cognitive Health - Portland

Portland, Oregon, 97225, United States
Charter Research - Lady Lake

Lady Lake, Florida, 32792, United States
Charter Research - Winter Park

Winter Park, Florida, 32792, United States
Clinical Research Professionals

Chesterfield, Missouri, 63005, United States
Coastal Family Medicine - Orange Park

Orange Park, Florida, 32073, United States
Coastal Neurology

Port Royal, South Carolina, 29935, United States
Conquest Research

Winter Park, Florida, 32789, United States
Emerald Coast Neurology

Pensacola, Florida, 32504, United States
Emory Alzheimer's Disease Research Center

Atlanta, Georgia, 30329, United States
Great Lakes Clinical Trials- Flourish Research- Chicago

Chicago, Illinois, 60640, United States
Great Lakes Clinical Trials- Flourish Research- Gurnee

Gurnee, Illinois, 60031, United States
Hattiesburg Clinic

Hattiesburg, Mississippi, 39401, United States
Insight Clinical Trials, LLC

Beachwood, Ohio, 44122, United States
Integrative Clinical Trials, LLC

Brooklyn, New York, 11229, United States
Intercoastal Medical Group - Sarasota

Sarasota, Florida, 34239, United States
JEM Research Institute

Atlantis, Florida, 33462, United States
Josephson Wallack Munshower Neurology, PC

Indianapolis, Indiana, 46256, United States
K2 Medical Research - Orlando

Orlando, Florida, 32806, United States
Las Vegas Medical Research

Las Vegas, Nevada, 89113, United States
Mercury Clinical Research

Sugarland, Texas, 77478, United States
Mid Hudson Medical Research

New Windsor, New York, 12553, United States
Mile High Research Center

Denver, Colorado, 80218, United States
Multi-Specialty Research Associates, Inc.

Lake City, Florida, 23055, United States
Neuro-Behavioral Clinical Research

Canton, Ohio, 44720, United States
NeuroStudies

Decatur, Georgia, 30033, United States
Neurological Associates of Albany

Albany, New York, 12208, United States
Neurology Center of North Orange County

Fullerton, California, 92835, United States
Neuropsychiatric Research Center of Southwest Florida

Fort Myers, Florida, 33912, United States
North Texas Clinical Trials

Fort Worth, Texas, 76104, United States
Northern Light Acadia Hospital

Bangor, Maine, 04402, United States
Office of Donald S. Marks, M.D., P.C.

Plymouth, Massachusetts, 02360, United States
Office of Elizabeth Zarate-Rowell, MD

Seal Beach, California, 90740, United States
Premier Clinical Research Institute Inc.

Miami, Florida, 30033, United States
Prisma Health Neurology

Columbia, South Carolina, 29203, United States
Progressive Medical Research

Port Orange, Florida, 32127, United States
QUEST Research Institute

Farmington, Michigan, 48334, United States
Quantum Laboratories

Pompano Beach, Florida, 33064, United States
ReCogniton Health

Fairfax, Virginia, 22031, United States
Sisu BHR, LLC

Springfield, Massachusetts, 01103, United States
South Lake Pain Institute

Clermont, Florida, 34711, United States
Suncoast Neuroscience Associates

St. Petersburg, Florida, 33713, United States
Syrentis Clinical Research

Santa Ana, California, 92705, United States
TRS Health

Stafford, Texas, 77477, United States
The Clinical Trial Center

Jenkintown, Pennsylvania, 19046, United States
The Cognitive and Research Center of New Jersey

Springfield, New Jersey, 07081, United States
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
UT Health San Antonio, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases

San Antonio, Texas, 78229, United States
University of Tennessee Medical Center

Knoxville, Tennessee, 37920, United States
Velocity Clinical Research - Syracuse

East Syracuse, New York, 13057, United States
Visionary Investigators Network- Aventura

Aventura, Florida, 33180, United States
Visionary Investigators Network- Miami

Miami, Florida, 33133, United States
Wasatch Clinical Research

Salt Lake City, Utah, 84107, United States