MCI

This study looks at how two common diabetes drug combinations affect thinking skills and depression risk in older adults with type 2 diabetes. Researchers will compare DPP-4 inhibitors plus metformin against SGLT2 inhibitors plus metformin in 300 people aged 55 and older. Partici…

This study tests a facial expression-based personalization engine (FPE) that monitors and adjusts cognitive training in real time to keep older adults engaged. Researchers will enroll 80 people aged 60-89 with mild cognitive impairment or subjective cognitive decline. The goal is…

This early-stage study is testing a radioactive tracer called [18F]Flortaucipir for PET scans in 18 Chinese adults with normal cognition, mild cognitive impairment, or Alzheimer's disease. The goal is to see if the tracer is safe and can help detect signs of Alzheimer's in the br…

This study is building a digital platform that uses simple, non-invasive tools like brain wave sensors, eye-tracking, and blood flow monitors to catch early signs of Alzheimer's disease. Researchers will follow 100 adults aged 55–80 with mild memory problems and compare them to h…

This study tests whether a personalized digital meditation program (MediTrain) can improve sleep, reduce stress, and boost thinking skills in older adults with mild cognitive impairment (MCI). Researchers will enroll 90 participants aged 60-85, comparing those with MCI to healthy…

This study tests a new AI-powered talk therapy called Smart Virtual Reminiscence (SVR) for older adults with mild dementia or memory problems. The therapy uses a virtual coach to help people share memories and improve their mood and thinking. Researchers want to see if it can red…

This study aims to find new biological markers for diseases like Alzheimer's, Parkinson's, and ALS by analyzing the genes, proteins, and metabolism of 1,200 patients. Researchers will use advanced technology to look for patterns that could help with earlier diagnosis, better prog…

This study aims to find the best amount of a digital meditation program to improve thinking skills and reduce stress in older adults. Researchers will enroll 4,000 people aged 60 and older who own a smartphone or tablet. Participants will use a meditation app, and their cognitive…

This study tests whether a non-invasive brain stimulation technique called TMS can improve working memory in healthy older adults and people with mild cognitive impairment (MCI). Researchers will use brain scans to personalize the stimulation to each person's brain networks. The …