MCI

This study tests a smart system that uses facial expressions to adjust computerized brain training in real time, aiming to keep older adults engaged and motivated. Researchers will enroll 80 people aged 60-89 with mild cognitive concerns. The goal is to see if this personalized a…

This early-stage study tests a radioactive tracer called [18F]Flortaucipir, used during a PET scan to detect tau protein tangles in the brain—a hallmark of Alzheimer's disease. Researchers will enroll 18 Chinese adults aged 50-85 with normal cognition, mild cognitive impairment, …

This study is testing a digital platform that uses EEG, eye-tracking, and blood flow sensors to detect early signs of Alzheimer's in people with mild cognitive impairment. Researchers will follow 100 participants aged 55–80 for 12 months to find markers that predict progression t…

This study tests a 5-week virtual cognitive training program for people aged 65-85 with mild cognitive impairment (MCI). Participants attend weekly two-hour group sessions online, learning memory strategies, mindfulness, and planning skills. Researchers want to see if the shorter…

This study tests a new kind of talk therapy called Smart Virtual Reminiscence (SVR) for older adults with mild cognitive impairment or early dementia. The therapy uses artificial intelligence to guide conversations about past memories, aiming to reduce troubling symptoms like agi…

This pilot study tests whether a personalized digital meditation app called MediTrain can help older adults with mild cognitive impairment (MCI) sleep better and feel less stressed. Participants will use the app for 30 minutes daily over 6 weeks. Researchers will measure changes …

This study is testing a tablet-based meditation game called MediTrain to see if it can help older adults improve their thinking skills and manage stress. Researchers will enroll 4,000 people aged 60 and older to find the best amount of game play needed for benefits. The game adap…

This study looks at whether two common diabetes drug combinations (SGLT2 inhibitors plus metformin vs. DPP-4 inhibitors plus metformin) affect memory and depression risk in older adults with type 2 diabetes. Researchers will track 300 participants over time using memory tests and…

This study aims to find new biological markers for neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS. Researchers will analyze genetic, protein, and metabolic data from 1,200 patients to improve diagnosis, predict disease course, and monitor treatment response. Th…

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to try to improve working memory in healthy older adults and people with mild cognitive impairment (MCI). Researchers will use brain scans to personalize the stimulation and measure its effects…