Can magnetic pulses sharpen aging brains? new trial aims to find out.

NCT ID NCT05460468

Recruiting now Knowledge-focused Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to try to improve working memory in healthy older adults and people with mild cognitive impairment (MCI). Researchers will use brain scans to personalize the stimulation and measure its effects on memory tasks and brain activity. The goal is to learn whether this approach can reliably enhance memory and guide future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial Magnetic Stimulation (TMS)
What this could lead to: If successful, this could point toward a noninvasive brain stimulation treatment to boost memory in older adults and those with mild cognitive impairment.
What could go wrong: This is an early-stage study focused on understanding brain networks, not a proven treatment. The approach may not translate into lasting memory benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MCI MILD COGNITIVE IMPAIRMENT

Contacts and locations

Locations

Duke University Hospital
RECRUITING

Durham, North Carolina, 27710, United States

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